How dsDNA breathing enhances its flexibility and instability on short length scales
Soft Condensed Matter
2015-05-14 v2
Abstract
We study the unexpected high flexibility of short dsDNA which recently has been reported by a number of experiments. Via the Langevin dynamics simulation of our Breathing DNA model, first we observe the formation of bubbles within the duplex and also forks at the ends, with the size distributions independent of the contour length. We find that these local denaturations at a physiological temperature, despite their rare and transient presence, can lower the persistence length drastically for a short DNA segment in agreement with experiment.
Keywords
Cite
@article{arxiv.1001.1956,
title = {How dsDNA breathing enhances its flexibility and instability on short length scales},
author = {O-chul Lee and Jae-Hyung Jeon and Wokyung Sung},
journal= {arXiv preprint arXiv:1001.1956},
year = {2015}
}