用于骨组织工程的具有高孔隙梯度结构的淀粉基纳米复合支架的制备与表征
摘要
淀粉基支架被视为骨组织工程中颇具前景的生物材料。本研究通过引入不同生物添加剂,包括柠檬酸、纤维素纳米纤维和羟基磷灰石(HA)纳米颗粒,采用单向低温冷冻铸造并随后冷冻干燥的方法,制备了具有高孔隙梯度孔结构的淀粉/聚乙烯醇(PVA)基纳米复合支架。傅里叶变换红外(FTIR)光谱证实了在柠檬酸作为交联剂存在下,淀粉与 PVA 分子通过多重酯化现象发生交联。场发射扫描电子显微镜(FE-SEM)观察显示形成了排列的层状孔隙,梯度孔径范围为 80 至 292 um,既良好满足骨再生的孔径要求,也显示了纤维素与 HA 纳米填料在支架基体中的均匀分散。基于力学测试结果,纤维素-HA 增强支架在干态下具有用于非承重应用的充足压缩模量与屈服强度;并在湿态下呈现快速响应的形状恢复。依据体外评估,HA 纳米颗粒作为异相成核位点广泛诱导了磷灰石相矿化。同时揭示,纤维素与 HA 纳米填料分别减缓与加速了支架生物降解速率。MTT 实验证明了该纳米复合支架与成骨细胞的良好细胞相容性。最后表明,所引入支架为细胞黏附提供了适宜平台。
引用
@article{arxiv.1810.02524,
title = {Fabrication and Characterization of a Starch-Based Nanocomposite Scaffold with Highly Porous and Gradient Structure for Bone Tissue Engineering},
author = {Fereshtehsadat Mirab and Mohammadjavad Eslamian and Reza Bagheri},
journal= {arXiv preprint arXiv:1810.02524},
year = {2018}
}
备注
This is the version of the article before peer review or editing, as submitted by an author to Biomedical Physics & Engineering Express (BPEX). IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.1088/2057-1976/aad74a