An Analytical Approach to the Protein Designability Problem
Soft Condensed Matter
2009-10-31 v1 Statistical Mechanics
q-bio
Abstract
We present an analytical method for determining the designability of protein structures. We apply our method to the case of two-dimensional lattice structures, and give a systematic solution for the spectrum of any structure. Using this spectrum, the designability of a structure can be estimated. We outline a heirarchy of structures, from most to least designable, and show that this heirarchy depends on the potential that is used.
Cite
@article{arxiv.cond-mat/9904377,
title = {An Analytical Approach to the Protein Designability Problem},
author = {Edo L. Kussell and Eugene I. Shakhnovich},
journal= {arXiv preprint arXiv:cond-mat/9904377},
year = {2009}
}
Comments
16 pages 4 figures