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The viral load is known to be a chief predictor of the risk of transmission of infectious diseases. In this work, we investigate the role of the individuals' viral load in the disease transmission by proposing a new…

Adaptation and Self-Organizing Systems · Physics 2023-03-29 Rossella Della Marca , Nadia Loy , Andrea Tosin

In this work we introduce a differential equation model with time-delay that describes the three-stage dynamics and the two time scales observed in HIV infection. Assuming that the virus has high mutation and rapid reproduction rates that…

Biological Physics · Physics 2015-03-13 Flora S. Bacelar , Roberto F. S. Andrade , Rita M. Zorzenon dos Santos

Traditional epidemic models consider that individual processes occur at constant rates. That is, an infected individual has a constant probability per unit time of recovering from infection after contagion. This assumption certainly fails…

Populations and Evolution · Quantitative Biology 2013-03-18 Guillermo Abramson , Sebastian Gonçalves , Marcelo F. C. Gomes

Infectious diseases, either emerging or long-lasting, place numerous people at risk and bring heavy public health burdens worldwide. In the process against infectious diseases, predicting the epidemic risk by modeling the disease…

Machine Learning · Computer Science 2023-08-08 Mutong Liu , Yang Liu , Jiming Liu

This technical report describes a dynamic causal model of the spread of coronavirus through a population. The model is based upon ensemble or population dynamics that generate outcomes, like new cases and deaths over time. The purpose of…

We propose a model of the immunity to a cyclical epidemic disease taking account not only of seasonal boosts during the infectious season, but also of residual immunity remaining from one season to the next. The focus is on the exponential…

Populations and Evolution · Quantitative Biology 2024-04-22 Siyu Chen , David Sankoff

We propose a compartmental model for epidemiology wherein the population is split into groups with either comply or refuse to comply with protocols designed to slow the spread of a disease. Parallel to the disease spread, we assume that…

Dynamical Systems · Mathematics 2025-11-27 Christian Parkinson , Weinan Wang

We develop a stochastic two-patch epidemic model with nonlinear recidivism to investigate infectious disease dynamics in heterogeneous populations. Extending a deterministic framework, we introduce stochasticity to account for random…

Populations and Evolution · Quantitative Biology 2024-05-21 Juan G. Calvo , Mario I. Simoy , Juan P. Aparicio , José E. Chacón , Fabio Sanchez

Traditional disease transmission models assume that the infectious period is exponentially distributed with a recovery rate fixed in time and across individuals. This assumption provides analytical and computational advantages, however it…

Populations and Evolution · Quantitative Biology 2024-01-30 Laura Di Domenico , Eugenio Valdano , Vittoria Colizza

We study epidemic models where the infectivity of each individual is a random function of the infection age (the elapsed time of infection). To describe the epidemic evolution dynamics, we use a stochastic process that tracks the number of…

Probability · Mathematics 2023-01-02 Guodong Pang , Etienne Pardoux

The focus of this article is on the dynamics of a new susceptible-infected model which consists of a susceptible group ($S$) and two different infectious groups ($I_1$ and $I_2$). Once infected, an individual becomes a member of one of…

Populations and Evolution · Quantitative Biology 2020-06-01 Ayse Peker-Dobie , Semra Ahmetolan , Ayse Humeyra Bilge , Ali Demirci

In this survey paper, we review the recent advances in individual based non--Markovian epidemic models. They include epidemic models with a constant infectivity rate, varying infectivity rate or infection-age dependent infectivity,…

Probability · Mathematics 2022-09-26 Raphael Forien , Guodong Pang , Etienne Pardoux

Human diseases spread over networks of contacts between individuals and a substantial body of recent research has focused on the dynamics of the spreading process. Here we examine a model of two competing diseases spreading over the same…

Physics and Society · Physics 2015-03-19 Brian Karrer , M. E. J. Newman

The SIR model is a three-compartment model of the time development of an epidemic. After normalizing the dependent variables, the model is a system of two non-linear differential equations for the susceptible proportion $S$ and the infected…

Dynamical Systems · Mathematics 2021-04-27 William G. Faris

An SEIRS epidemic with disease fatalities is introduced in a growing population (modelled as a super-critical linear birth and death process). The study of the initial phase of the epidemic is stochastic, while the analysis of the major…

Populations and Evolution · Quantitative Biology 2017-03-29 Tom Britton , Désiré Ouédraogo

Developing the ability to comprehensively study infections in small populations enables us to improve epidemic models and better advise individuals about potential risks to their health. We currently have a limited understanding of how…

Applications · Statistics 2014-10-14 Wen Dong , Katherine A. Heller , Alex Sandy Pentland

This paper investigates the long-time dynamics of a nonlocal epidemic model with free boundaries, where a pathogen with density $u(t,x)$ and the infected humans with density $v(t,x)$ evolve according to a reaction-diffusion system with…

Analysis of PDEs · Mathematics 2026-02-06 Yao Chen , Yihong Du , Wan-Tong Li , Rong Wang

This article introduces epidemia, an R package for Bayesian, regression-oriented modeling of infectious diseases. The implemented models define a likelihood for all observed data while also explicitly modeling transmission dynamics: an…

We formulate an age-structured nonlinear partial differential equation model that features short-term immigration effects in a population. Individuals can immigrate into the population as any of the three stages in the model: susceptible,…

Populations and Evolution · Quantitative Biology 2019-08-07 Fabio Sanchez , Juan Gabriel Calvo

We investigate the effects of heterogeneous and clustered contact patterns on the timescale and final size of infectious disease epidemics. The abundance of transitive relationships (the number of 3 cliques) in a network and the variance of…

Quantitative Methods · Quantitative Biology 2010-06-07 Erik M Volz