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We study the spread of susceptible-infected-recovered (SIR) infectious diseases where an individual's infectiousness and probability of recovery depend on his/her "age" of infection. We focus first on early outbreak stages when stochastic…

Populations and Evolution · Quantitative Biology 2009-05-14 Joel Miller , Bahman Davoudi , Rafael Meza , Anja Slim , Babak Pourbohloul

We develop an extension of the Susceptible-Infected-Recovery (SIR) model to account for spatial variations in population as well as infection and recovery parameters. The equations are derived by taking the continuum limit of discrete…

Mesoscale and Nanoscale Physics · Physics 2025-02-04 Abhimanyu Ghosh

Mathematical models of infectious disease transmission typically neglect within-host dynamics. Yet within-host dynamics - including pathogen replication, host immune responses, and interactions with microbiota - are crucial not only for…

Populations and Evolution · Quantitative Biology 2023-12-20 Cameron A. Smith , Ben Ashby

We study the Susceptible-Infected-Susceptible model of the spread of an endemic infection. We calculate an exact expression for the mean number of transmissions for all values of the population and the infectivity. We derive the large-N…

Populations and Evolution · Quantitative Biology 2007-09-20 David A. Kessler

The global public health landscape is perpetually challenged by the looming threat of infectious diseases. Central to addressing this concern is the imperative to prevent and manage disease transmission during pandemics, particularly in…

Populations and Evolution · Quantitative Biology 2024-04-19 Xue Liu , Yue Deng , Jingying Huang , Yuhong Zhang , Jinzhi Lei

The SIR model with spatially inhomogeneous infection rate is studied with numerical simulations in one, two, and three dimensions, considering the case that the infection spreads inhomogeneously in densely populated regions or hot spots. We…

Medical Physics · Physics 2020-12-25 Hidetsugu Sakaguchi , Yuta Nakao

In this paper we analyze a continuous-time epidemic model and its discrete counterpart, where infection spreads both horizontally and vertically. We consider three cases: model with horizontal and imperfect vertical transmissions, model…

Dynamical Systems · Mathematics 2019-06-10 Priyanka Saha , Nandadulal Bairagi

We study a stochastic epidemic model with multiple patches (locations), where individuals in each patch are categorized into three compartments, Susceptible, Infected and Recovered/Removed, and may migrate from one patch to another in any…

Probability · Mathematics 2023-08-21 Guodong Pang , Etienne Pardoux

Understanding the spread of any disease is a highly complex and interdisciplinary exercise as biological, social, geographic, economic, and medical factors may shape the way a disease moves through a population and options for its eventual…

Populations and Evolution · Quantitative Biology 2016-12-14 Aristides Moustakas

Memory has a great impact on the evolution of every process related to human societies. Among them, the evolution of an epidemic is directly related to the individuals' experiences. Indeed, any real epidemic process is clearly sustained by…

Physics and Society · Physics 2017-03-10 M. Saeedian , M. Khalighi , N. Azimi-Tafreshi , G. R. Jafari , M. Ausloos

We study the impact of contact heterogeneity on epidemic dynamics. A system characterized by multiple susceptible populations is considered. The description of the spread of an infectious disease is obtained through the study of a system of…

Physics and Society · Physics 2021-11-11 Andrea Medaglia , Mattia Zanella

Epidemic models are invaluable tools to understand and implement strategies to control the spread of infectious diseases, as well as to inform public health policies and resource allocation. However, current modeling approaches have…

Methodology · Statistics 2026-05-12 Caitlin Ward , Rob Deardon , Alexandra M. Schmidt

The immune response to a pathogen has two basic features. The first is the expansion of a few pathogen-specific cells to form a population large enough to control the pathogen. The second is the process of differentiation of cells from an…

Populations and Evolution · Quantitative Biology 2014-02-04 Sean P Stromberg , Rustom Antia , Ilya Nemenman

Background: Recently developed techniques to study the spread of infectious diseases through networks make assumptions that the initial proportion infected is infinitesimal and the population behavior is static throughout the epidemic. The…

Populations and Evolution · Quantitative Biology 2012-08-17 Joel C. Miller

This paper gives an introduction to rule-based modelling applied to topics in infectious diseases. Rule-based models generalise reaction-based models with reagents that have internal state and may be bound together to form complexes, as in…

Populations and Evolution · Quantitative Biology 2021-08-10 William Waites , Matteo Cavaliere , David Manheim , Jasmina Panovska-Griffiths , Vincent Danos

Many infectious diseases are comprised of multiple strains with examples including Influenza, tuberculosis, and Dengue virus. The time evolution of such systems is linked to a complex landscape shaped by interactions between competing…

Populations and Evolution · Quantitative Biology 2023-11-21 Nir Gavish , Musa Rabiu

Viral kinetics have been extensively studied in the past through the use of spatially well-mixed ordinary differential equations describing the time evolution of the diseased state. However, emerging spatial structures such as localized…

Cell Behavior · Quantitative Biology 2024-04-02 Catherine Beauchemin

We consider the spread of infectious disease through contact networks of Configuration Model type. We assume that the disease spreads through contacts and infected individuals recover into an immune state. We discuss a number of existing…

Populations and Evolution · Quantitative Biology 2014-03-11 Joel C Miller , Istvan Z Kiss

A nonlinear cross-diffusion epidemic with a time-dependent Susceptible-Infected-Recovered-Died system is proposed in this paper. This system is derived from kinetic theory model by multiscale approach, which leads to an equivalent system…

Populations and Evolution · Quantitative Biology 2021-09-01 Mohamed Zagour

Why are the epidemic patterns of COVID-19 so different among different cities or countries which are similar in their populations, medical infrastructures, and people's behavior? Why are forecasts or predictions made by so-called experts…

Populations and Evolution · Quantitative Biology 2020-06-03 Hisashi Kobayashi
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