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We present a simple and computationally efficient coarse-grained and solvent-free model for simulating lipid bilayer membranes. In order to be used in concert with particle-based reaction-diffusion simulations, the model is purely based on…

Biological Physics · Physics 2018-01-31 Mohsen Sadeghi , Thomas R. Weikl , Frank Noé

Inelastic neutron and X-ray scattering experiments on surfaces and interfaces are a challenging topic in modern physics. Particular interest arises regarding surfaces and interfaces of soft matter and biological systems. We review both…

Biological Physics · Physics 2009-10-02 Maikel C. Rheinstädter , Tilo Seydel , Bela Farago , Tim Salditt

We investigate the influence of a non-ionic surfactant like polymer on phospholipid vesicles. Our results from cryogenic transmission electron microscopy (cryo-TEM), dynamic light scattering (DLS), small angle neutron and X-ray scattering…

We report incoherent quasielastic neutron scattering experiments on the thermotropic liquid crystal 4-n-cyano-4'-octylbiphenyl. The combination of time-of-flight and backscattering data allows analyzing the intermediate scattering function…

The influence of dimethyl sulfoxide (DMSO) on membrane thickness, multilamellar repeat distance, and phase transitions of 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) was investigated by X-ray diffraction and small-angle neutron…

Biological Physics · Physics 2007-05-23 M. A. Kiselev , P. Lesieur , A. M. Kisselev , C. Grabielle-Madelmond , M. Ollivon

We study phase behaviours of lipid--bilayer vesicles functionalised by ligand--receptor complexes made of synthetic DNA by introducing a modelling framework and a dedicated experimental platform. In particular, we perform Monte Carlo…

Soft Condensed Matter · Physics 2016-08-23 S. J. Bachmann , J. Kotar , L. Parolini , A. Šarić , P. Cicuta , L. Di Michele , B. M. Mognetti

We investigate the mechanical properties of bilayers of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine in the gel phase by using peak force tapping with quantitative nanomechanical mapping. We study both dry and aqueous bilayers and liposomes…

Soft Condensed Matter · Physics 2021-02-04 Luca Quaroni , Kingshuk Bandopadhyay , Marzena Mach , Paweł Wydro , Szczepan Zapotoczny

We investigated the properties of bilayer fluctuations using molecular dynamics. We modeled the amphipathic molecules as a diatomic molecule, constructed a bilayer in the solvent, and observed the Fourier spectrum of its fluctuations. The…

Statistical Mechanics · Physics 2024-10-14 Shunta Kikuchi , Hiroshi Watanabe

Understanding how lipid bilayers respond to pressure is essential for interpreting the coupling between membrane proteins and their native environments. Here, we use all-atom molecular dynamics to examine the pressure-temperature behavior…

Soft Condensed Matter · Physics 2026-01-12 Yanna Gautier , Guillaume Stirnemann , Jérôme Hénin

We present incoherent quasi-elastic neutron scattering measurements in a wavevector transfer range from 0.4 AA^{-1} to 1.6AA^{-1} on liquid n-hexane confined in cylindrical, parallel-aligned nanochannels of 6 nm mean diameter and 260…

Soft Condensed Matter · Physics 2012-04-12 Tommy Hofmann , Dirk Wallacher , Maria Mayorova , Reiner Zorn , Bernhard Frick , Patrick Huber

We theoretically investigate the relaxation dynamics of a nearly-flat binary lipid bilayer membrane by taking into account the membrane tension, hydrodynamics of the surrounding fluid, inter-monolayer friction and mutual diffusion in each…

Soft Condensed Matter · Physics 2016-05-05 Ryuichi Okamoto , Yuichi Kanemori , Shigeyuki Komura , Jean-Baptiste Fournier

Drawing an analogy to the paradigm of quasi-elastic neutron scattering, we present a general approach for quantitatively investigating the spatiotemporal dependence of structural anisotropy relaxation in deformed polymers by using…

We study the indentation of a free-standing lipid membrane suspended over a nanopore on a hydrophobic substrate by means of molecular dynamics simulations. We find that in the course of indentation, the membrane bends at the point of…

Soft Condensed Matter · Physics 2011-08-26 Chen-Hsi Huang , Pai-Yi Hsiao , Fan-Gang Tseng , Shih-Kang Fan , Chien-Chung Fu , Rong-Long Pan

Phospholipid monolayers at the air-water interface serve as model systems for various biological interfaces, e.g. lung surfactant layers and outer leaflets of cell membranes. Although the dynamical (viscoelastic) properties of these…

Fluid Dynamics · Physics 2009-11-19 Siyoung Q. Choi , Todd M. Squires

We investigate with computer simulations the critical radius of pores in a lipid bilayer membrane. Ilton et al. (2016) recently showed that nucleated pores in a homopolymer film can increase or decrease in size, depending on whether they…

Soft Condensed Matter · Physics 2017-10-26 Clark Bowman , Mark Chaplain , Anastasios Matzavinos

Neutron scattering and molecular dynamics studies were performed on a concentrated aqueous tetramethylammonium (TMA) chloride solution to gain insight into the hydration shell structure of TMA, which is relevant for understanding its…

Water hydrating phospholipid membranes determine their stability and function, as well as their interaction with other molecules. In this article we study, using all-atom molecular dynamics simulations, the rotational and translational…

Soft Condensed Matter · Physics 2016-05-25 Carles Calero , H. Eugene Stanley , Giancarlo Franzese

The rich thermotropic behavior of lipid bilayers is addressed using phenomenological theory informed by many experiments. The most recent experiment not yet addressed by theory has shown that the tilt modulus in DMPC lipid bilayers…

Soft Condensed Matter · Physics 2023-07-12 John F. Nagle

In this paper we present a review on our recent experimental investigations into the phase behavior of the deeply cooled water confined in a nanoporous silica material, MCM-41, with elastic neutron scattering technique. Under such strong…

Soft Condensed Matter · Physics 2016-12-13 Zhe Wang , Kanae Ito , Sow-Hsin Chen

By reverting to spectroscopy, changes in the biological environment of a fluorescent probe can be monitored and the presence of various phases of the surrounding lipid bilayer membranes can be detected. This study highlights the important…

Soft Condensed Matter · Physics 2019-10-23 S. Knippenberg , G. Fabre , S. Osella , F. Di Meo , M. Paloncýová , M. Ameloot , P. Trouillas