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Cationic lipid membranes are known to form compact complexes with DNA and to be effective as gene delivery agents both in vitro and in vivo. Here we employ molecular dynamics simulations for a detailed atomistic study of lipid bilayers…

Soft Condensed Matter · Physics 2009-11-10 A. A. Gurtovenko , Michael Patra , Mikko Karttunen , Ilpo Vattulainen

Temperature controlled Polarization Modulation Near-Field Scanning Optical Microscopy (PM-NSOM) measurements of a single supported $L_{\beta^{\prime}}$ 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) lipid bilayer are presented. The…

Soft Condensed Matter · Physics 2020-04-01 Merrell A. Johnson , Ricardo S. Decca

Droplet interface bilayers are a convenient model system to study the physio-chemical properties of phospholipid bilayers, the major component of the cell membrane. The mechanical response of these bilayers to various external mechanical…

Biological Physics · Physics 2021-02-08 Yaoqi Huang , Vineeth Chandran Suja , Javier Tajuelo , Gerald G. Fuller

We present a study of the dynamics and structural changes for trans-1,2-dichloroethylene between high and low density liquids using neutron scattering techniques (diffraction, small angle neutron scattering and time of flight spectroscopy)…

Lipid membranes have complex compositions and modeling the thermodynamic properties of multi-component lipid systems remains a remote goal. In this work we attempt to describe the thermodynamics of binary lipid mixtures by mapping…

Soft Condensed Matter · Physics 2024-09-04 L. Berezovska , R. Kociurzynski , F. Thalmann

We present a simple, and physically motivated, coarse-grained model of a lipid bilayer, suited for micron scale computer simulations. Each ~25 nm^2 patch of bilayer is represented by a spherical particle. Mimicking forces of hydrophobic…

Soft Condensed Matter · Physics 2015-05-13 Andrea Pasqua , Lutz Maibaum , George Oster , Daniel A. Fletcher , Phillip L. Geissler

During this experiment we were testing the hypothesis that standing waves in a phospholipid membrane stack indeed lead to a detectable signal in coherent grazing-incidence small-angle neutron scattering, GISANS. These modes were identified…

The study of interactions between biomimetic membranes and micron-sized particles is crucial for understanding various biological processes. Here, we control microparticle spontaneous engulfment by giant lipid vesicles by tuning particle…

Soft Condensed Matter · Physics 2025-01-22 Clément Marque , Gaetano D'Avino , Domenico Larobina , Aude Michel , Ali Abou-Hassan , Antonio Stocco

In this paper we present the results of a large-scale numerical investigation of structural properties of a model of cell membrane, simulated as a bilayer of flexible molecules in vacuum. The study was performed by carrying out extensive…

Biological Physics · Physics 2009-11-07 G. La Penna , S. Letardi , V. Minicozzi , S. Morante , G. C. Rossi , G. Salina

We study lipid translocation ("flip-flop") between the leaflets of a planar lipid bilayer with transition path sampling (TPS). Rare flip-flops compete with biological machineries that actively establish asymmetric lipid compositions.…

Soft Condensed Matter · Physics 2025-02-18 Matthias Post , Gerhard Hummer

The kinematic lower bound for the single scattering of neutrons produced in DT fusion reactions produces a backscatter edge in the measured neutron spectrum. The energy spectrum of backscattered neutrons is dependent on the scattering ion…

The equilibrium distance between two lipid bilayers stable in bulk water and in proximity of a substrate was investigated. Samples consisted of a homogeneous lipid bilayer, floating near an identical bilayer deposited on the hydrophilic…

Soft Condensed Matter · Physics 2007-05-23 Giovanna Fragneto , Thierry Charitat , Edith Bellet-Amalric , Robert Cubitt , Francois Graner

The lateral diffusion of lipids within membrane is of paramount importance, serving as a central mechanism in numerous physiological processes including cell signaling, membrane trafficking, protein activity regulation, and energy…

Soft Condensed Matter · Physics 2024-07-09 V. K. Sharma , H. Srinivasan , J. Gupta , S. Mitra

Water activity and its relationship with interactions stabilising lamellar stacks of mixed lipid bilayers in their fluid state are investigated by means of osmotic pressure measurements coupled with small-angle x-ray scattering. The…

The dynamics of a physical gel, namely the Low Molecular Mass Organic Gelator {\textit Methyl-4,6-O-benzylidene-$\alpha$ -D-mannopyranoside ($\alpha$-manno)} in water and toluene are probed by neutron scattering. Using high gelator…

Soft Condensed Matter · Physics 2015-02-06 Sylvie Spagnoli , Isabelle Morfin , Miguel A. Gonzalez , Pierre Carcabal , Marie Plazanet

The presence and the properties of lipid bilayer nanometer-scale domains might be important for understanding the membranes of living cells. We used molecular dynamics (MD) simulations to investigate perturbations of a small patch of…

Soft Condensed Matter · Physics 2011-06-01 Frederick A. Heberle , David G. Ackerman , Gerald W. Feigenson

Membrane proteins serve a wide range of vital roles in the functioning of living organisms. Compared to other classes of proteins, determining membrane protein structures remains a challenge, in large part due to the difficulty in…

It was recently discovered that friction between surfaces bearing phosphatidylcholine (PC) lipid bilayers can be increased by two orders of magnitude or more via an externally-applied electric field, and that this increase is fully…

Soft Condensed Matter · Physics 2024-09-26 Di Jin , Jacob Klein

Among the different dynamical processes that take place in polymers, methyl group rotation is perhaps the simplest one, since all the relevant interactions on the methyl group can be condensed in an effective mean-field one-dimensional…

Soft Condensed Matter · Physics 2007-05-23 Juan Colmenero , Angel J. Moreno , Angel Alegria

The impact of nanomaterials on lung fluids or on the plasma membrane of living cells has prompted researchers to examine the interactions between nanoparticles and lipid vesicles. Recent studies have shown that nanoparticle-lipid…

Soft Condensed Matter · Physics 2021-09-21 F. Mousseau , E. K. Oikonomou , V. Baldim , S. Mornet , J. -F. Berret