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There is an increasing level of interest in open-endedness in the recent literature of Artificial Life and Artificial Intelligence. We previously proposed the cardinality leap of possibility spaces as a promising mechanism to facilitate…

Neural and Evolutionary Computing · Computer Science 2025-02-05 Hiroki Sayama

Chirality is ubiquitous in nature and fundamental in science, from particle physics to metamaterials.The most established technique of chiral discrimination - photoabsorption circular dichroism - relies on the magnetic properties of a…

Biological molecules chose one of two structurally, chiral systems which are related by reflection in a mirror. It is proposed that this choice was made, causally, by magnetically polarized and physically chiral cosmic-rays, which are known…

Other Quantitative Biology · Quantitative Biology 2022-07-11 Noemie Globus , Roger D. Blandford

Spatial heterogeneity can have dramatic effects on the biochemical networks that drive cell regulation and decision-making. For this reason, a number of methods have been developed to model spatial heterogeneity and incorporated into widely…

Subcellular Processes · Quantitative Biology 2018-10-30 Jose-Juan Tapia , Ali Sinan Saglam , Jacob Czech , Robert Kuczewski , Thomas M. Bartol , Terrence J. Sejnowski , James R. Faeder

Characterizing chirality is highly important for applications in the pharmaceutical industry, as well as in the study of dynamical chemical and biological systems. However, this task has remained challenging, especially due to the ongoing…

Chemical Physics · Physics 2022-01-28 Ofer Neufeld , Omri Wengrowicz , Or Peleg , Angel Rubio , Oren Cohen

Cellular heterogeneity is an immanent property of biological systems that covers very different aspects of life ranging from genetic diversity to cell-to-cell variability driven by stochastic molecular interactions, and noise induced cell…

Quantitative Methods · Quantitative Biology 2021-09-15 Niko Komin , Alexander Skupin

We propose a computational method to simulate anomalous self-diffusion in a simple liquid. The method is based on a molecular dynamics simulation on which we impose the following two conditions: firstly, the inter-particle interaction is…

Statistical Mechanics · Physics 2010-04-07 Simon Standaert , Jan Ryckebusch , Lesley De Cruz

The requisites for the persistence of small colonies of self-replicating molecules living in a two-dimensional lattice are investigated analytically in the infinite diffusion or mean-field limit and through Monte Carlo simulations in the…

Biological Physics · Physics 2009-11-07 Claudia P. Ferreira , J. F. Fontanari

In chemistry and biochemistry, chirality represents the structural asymmetry characterized by non-superimposable mirror images for a material like DNA. In physics, however, chirality commonly refers to the spin-momentum locking of a…

Materials Science · Physics 2024-08-07 Binghai Yan

Since the lipid raft model was developed at the end of the last century, it became clear that the specific molecular arrangements of phospholipid assemblies within a membrane have profound implications in a vast range of physiological…

Soft Condensed Matter · Physics 2024-04-19 Alexander P. Fellows , Ben John , Martin Wolf , Martin Thämer

Conventional linear optical activity effects are widely used for studying chiral materials. However, poor contrast and artifacts due to sample anisotropy limit the applicability of these methods. Here we demonstrate that nonlinear…

Biological Physics · Physics 2016-02-16 Mei-Yu Chen , Mikko J. Huttunen , Che-Wei Kan , Yen-Yin Lin , Cin-Wei Ye , Meng-Jer Wu , Hsiang-Lin Liu , Shi-Wei Chu

Liquid crystal mesophases of achiral molecules are normally achiral, yet in a few materials they spontaneously segregate and form right- and left-handed chiral domains. One mechanism that drives chiral segregation is molecular shape…

Soft Condensed Matter · Physics 2026-01-16 Matthew J. Deutsch , Robin L. B. Selinger , Paul van der Schoot

All life, including cells and artificial protocells, must integrate diverse molecules into a single unit in order to reproduce. Despite expected pressure to evolve a simple system with the fastest replication speed, the mechanism by which…

Cell Behavior · Quantitative Biology 2014-08-12 Atsushi Kamimura , Kunihiko Kaneko

We introduce mesoscopic and macroscopic model equations of chemotaxis with anomalous subdiffusion for modelling chemically directed transport of biological organisms in changing chemical environments with diffusion hindered by traps or…

Dynamical Systems · Mathematics 2012-12-03 T. A. M. Langlands , B. I. Henry

A coupled system of nonlinear mixed-type equations modeling early stages of angiogenesis is analyzed in a bounded domain. The system consists of stochastic differential equations describing the movement of the positions of the tip and stalk…

Analysis of PDEs · Mathematics 2022-06-24 Markus Fellner , Ansgar Jüngel

We describe a mechanism for pronounced biochemical oscillations, relevant to microscopic systems, such as the intracellular environment. This mechanism operates for reaction schemes which, when modeled using deterministic rate equations,…

Cell Behavior · Quantitative Biology 2009-11-13 A. J. McKane , J. D. Nagy , T. J. Newman , M. O. Stefanini

The first off-lattice Monte Carlo kinetics model of interstellar dust-grain surface chemistry is presented. The positions of all surface particles are determined explicitly, according to the local potential minima resulting from the…

Instrumentation and Methods for Astrophysics · Physics 2015-06-17 Robin T. Garrod

Intimately connected to the rule of life, chirality remains a long-time fascination in biology, chemistry, physics and materials science. Chiral structures, e.g., nucleic acid and cholesteric phase developed from chiral molecules are common…

To understand the relationship between the chirality of individual cells and that of tissues and organisms, we have developed a chiral polarized particle model to investigate the movement of cell populations on substrates. Our model…

Biological Physics · Physics 2024-07-02 Xi Li , Bin Chen

Observations of elemental abundances in the Galaxy have repeatedly shown an intrinsic scatter as a function of time and metallicity. The standard approach to chemical evolution does not attempt to address this scatter in abundances since…

Astrophysics · Physics 2009-10-28 Craig J. Copi
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