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We critically investigate current statistical tests applied to high redshift clusters of galaxies in order to test the standard cosmological model and describe their range of validity. We carefully compare a sample of high-redshift,…

Cosmology and Nongalactic Astrophysics · Physics 2015-05-30 Ben Hoyle , Raul Jimenez , Licia Verde , Shaun Hotchkiss

The distribution and heritability of many traits depends on numerous loci in the genome. In general, the astronomical number of possible genotypes makes the system with large numbers of loci difficult to describe. Multilocus evolution,…

Populations and Evolution · Quantitative Biology 2012-08-01 Richard A. Neher , Boris I. Shraiman

In order to design clusters with desired properties, we have implemented a suite of genetic algorithms tailored to optimize for low total energy, high vertical electron affinity (VEA), and low vertical ionization potential (VIP). Applied to…

We investigate the number $V_p(n)$ of distinct sites visited by an $n$-step resetting random walker on a $d$-dimensional hypercubic lattice with resetting probability $p$. In the case $p=0$, we recover the well-known result that the average…

Statistical Mechanics · Physics 2022-06-08 Marco Biroli , Francesco Mori , Satya N. Majumdar

The overarching goal of this paper is to solve the word problem for a class of idempotent commutative monoids whose elements model population haplotypes. More specifically, we design an algebraic framework in which it is possible to unravel…

Category Theory · Mathematics 2023-03-09 Rémy Tuyéras

This paper develops mathematical models describing the evolutionary dynamics of both asexually and sexually reproducing populations of diploid unicellular organisms. We consider two forms of genome organization. In one case, we assume that…

Populations and Evolution · Quantitative Biology 2009-07-17 Maya Kleiman , Emmanuel Tannenbaum

Relation between problem hardness and solution space structure is an important research aspect. Model d-k-CSP generates very hard instances when $r=1$ and $r$ is near 1, where $r$ represents normalized constraint density. We find that when…

Disordered Systems and Neural Networks · Physics 2019-04-09 Wei Xu , Fuzhou Gong , Guangyan Zhou

The prevalence of neutral mutations implies that biological systems typically have many more genotypes than phenotypes. But can the way that genotypes are distributed over phenotypes determine evolutionary outcomes? Answering such questions…

Populations and Evolution · Quantitative Biology 2015-09-28 Kamaludin Dingle , Steffen Schaper , Ard A. Louis

Extending the previous 2-gender dioecious diploid gene-mating evolution model [arXiv:1410.3456], we attempt to answer "whether the Hardy-Weinberg global stability and the exact analytic dynamical solutions can be found in the generalized…

Populations and Evolution · Quantitative Biology 2020-07-22 Juven Wang

The 0/1 knapsack problem is weakly NP-hard in that there exist pseudo-polynomial time algorithms based on dynamic programming that can solve it exactly. There are also the core branch and bound algorithms that can solve large randomly…

Neural and Evolutionary Computing · Computer Science 2019-03-11 Shalin Shah

This paper studies the computational difficulty of clustering problems that are defined directly on a continuous probability density. Rather than working with finite samples, we assume the density is given as a polynomial and ask whether it…

Computational Complexity · Computer Science 2026-05-01 Angshul Majumdar

The human genotope is the convex hull of all allele frequency vectors that can be obtained from the genotypes present in the human population. In this paper we take a few initial steps towards a description of this object, which may be…

Populations and Evolution · Quantitative Biology 2011-11-10 Peter Huggins , Lior Pachter , Bernd Sturmfels

Random braids that are formed by multiplying randomly chosen permutation braids are studied by analyzing their behavior under Garside's weighted decomposition and cycling. Using this analysis, we propose a polynomial-time algorithm to the…

Geometric Topology · Mathematics 2007-05-23 Ki Hyoung Ko , Jang Won Lee

We study theoretically a new generic scheme of programmable self-assembly of nanoparticles into clusters of desired geometry. The problem is motivated by the feasibility of highly selective DNA-mediated interactions between colloidal…

Soft Condensed Matter · Physics 2009-11-11 Nicholas A. Licata , Alexei V. Tkachenko

Using elementary rigorous methods we prove the existence of a clustered phase in the random $K$-SAT problem, for $K\geq 8$. In this phase the solutions are grouped into clusters which are far away from each other. The results are in…

Disordered Systems and Neural Networks · Physics 2007-05-23 M. Mezard , T. Mora , R. Zecchina

Partly on the basis of heuristic arguments from physics it has been suggested that the performance of certain types of algorithms on random $k$-SAT formulas is linked to phase transitions that affect the geometry of the set of satisfying…

Combinatorics · Mathematics 2017-11-17 Amin Coja-Oghlan , Amir Haqshenas , Samuel Hetterich

For any characteristic zero coefficient field, an irreducible representation of a finite $p$-group can be assigned a Roquette $p$-group, called the genotype. This has already been done by Bouc and Kronstein in the special cases Q and C. A…

Representation Theory · Mathematics 2018-10-01 Laurence Barker

Adaptation in response to selection on polygenic phenotypes may occur via subtle allele frequencies shifts at many loci. Current population genomic techniques are not well posed to identify such signals. In the past decade, detailed…

Populations and Evolution · Quantitative Biology 2014-08-19 Jeremy J. Berg , Graham Coop

Mutational robustness quantifies the effect of random mutations on fitness. When mutational robustness is high, most mutations do not change fitness or have only a minor effect on it. From the point of view of fitness landscapes, robust…

Populations and Evolution · Quantitative Biology 2019-10-22 Alexander Klug , Su-Chan Park , Joachim Krug

The Deligne-Simpson problem (DSP) (resp. the weak DSP) is formulated like this: {\em give necessary and sufficient conditions for the choice of the conjugacy classes $C_j\subset GL(n,{\bf C})$ or $c_j\subset gl(n,{\bf C})$ so that there…

Algebraic Geometry · Mathematics 2007-05-23 Vladimir Petrov Kostov
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