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In this paper we analyse a previously proposed cell-based model of glioblastoma (brain tumour) growth, which is based on the assumption that the cancer cells switch phenotypes between a proliferative and motile state (Gerlee and Nelander,…

Tissues and Organs · Quantitative Biology 2017-02-20 Philip Gerlee , Sven Nelander

Periodic driving of particles can create crystalline structures in their dynamics. Such systems can be used to study solid-state physics phenomena in the time domain. In addition, it is possible to realize photonic time crystals and to…

The aim of our work is to study the effect of geometry variation on nucleation times and to address its role in the context of eukaryotic chemotaxis (i.e. the process which allows cells to identify and follow a gradient of chemical…

Statistical Mechanics · Physics 2010-02-10 Carla Bosia , Michele Caselle , Davide Corá

In bacterial chemotaxis, E. coli cells drift up chemical gradients by a series of runs and tumbles. Runs are periods of directed swimming, and tumbles are abrupt changes in swimming direction. Near the beginning of each run, the rotating…

Soft Condensed Matter · Physics 2009-11-07 Thomas R. Powers

Active particles with their characteristic feature of self-propulsion are regarded as the simplest models for motility in living systems. The accumulation of active particles in low activity regions has led to the general belief that…

Soft Condensed Matter · Physics 2021-05-26 Hidde D. Vuijk , Holger Merlitz , Michael Lang , Abhinav Sharma , Jens-Uwe Sommer

Animal cells can sense chemical gradients without moving, and are faced with the challenge of migrating towards a target despite noisy information on the target position. Here we discuss optimal search strategies for a chaser that moves by…

Biological Physics · Physics 2015-03-18 Pawel Romanczuk , Guillaume Salbreux

Autologous chemotaxis is the process in which cells secrete and detect molecules to determine the direction of fluid flow. Experiments and theory suggest that autologous chemotaxis fails at high cell densities because molecules from other…

Biological Physics · Physics 2023-05-08 Louis González , Andrew Mugler

Escherichia coli is a motile bacterium that moves up a chemoattractant gradient by performing a biased random walk composed of alternating runs and tumbles. This paper presents calculations of the chemotactic drift velocity vd (the mean…

Quantitative Methods · Quantitative Biology 2008-04-16 J. T. Locsei , T. J. Pedley

Starting from the kinetic approach for a mixture of reacting gases whose particles interact through elastic scattering and a bimolecular reversible chemical reaction, the equations that govern the dynamics of the system are obtained by…

Soft Condensed Matter · Physics 2009-11-10 A. Rossani , A. M. Scarfone

Travelling waves of densities of binary fluid mixtures are investigated near a critical point. The free energy is considered in a non-local form taking account of the density gradients. The equations of motions are applied to a universal…

Classical Physics · Physics 2011-10-26 Henri Gouin , Augusto Muracchini , Tommaso Ruggeri

Single-cell organisms and various cell types use a range of motility modes when following a chemical gradient, but it is unclear which mode is best suited for different gradients. Here, we model directional decision-making in chemotactic…

Cell Behavior · Quantitative Biology 2025-05-12 Albert Alonso , Julius B. Kirkegaard , Robert G. Endres

Cells are constantly exposed to diverse stimuli-chemical, mechanical, or electrical-that guide their movement. In physiological conditions, these signals often overlap, as seen during infections, where neutrophils and dendritic cells…

Biological Physics · Physics 2026-03-25 Emiliano Perez Ipiña , Brian A. Camley

Bacteria such as Escherichia coli (E. coli) exhibit biased motion if kept in a spatially non-uniform chemical environment. Here, we bring out unique time-dependent characteristics of bacterial chemotaxis, in response to a diffusing spatial…

Biological Physics · Physics 2018-12-05 Sibendu Samanta , Ritwik Layek , Shantimoy Kar , Sudipta Mukhopadhyay , Suman Chakraborty

We study travelling-wave solutions for a reaction-diffusion system arising as a model for host-tissue degradation by bacteria. This system consists of a parabolic equation coupled with an ordinary differential equation. For large values of…

Analysis of PDEs · Mathematics 2007-05-23 Danielle Hilhorst , John R. King , Matthias Röger

An analysis of traveling wave solutions of partial differential equation (PDE) systems with cross-diffusion is presented. The systems under study fall in a general class of the classical Keller-Segel models to describe chemotaxis. The…

Numerical Analysis · Computer Science 2007-06-08 Faina Berezovskaya , Artem Novozhilov , Georgy Karev

We prove existence and uniqueness of travelling waves for a reaction-diffusion system coupling a classical reaction-diffusion equation in a strip with a diffusion equation on a line. To do this we use a continuation method which leads to…

Analysis of PDEs · Mathematics 2014-10-20 Laurent Dietrich

Cells are often considered input-output devices that maximize the transmission of information by converting extracellular stimuli (input) via signaling pathways (communication channel) to cell behavior (output). However, in biological…

Cell Behavior · Quantitative Biology 2019-11-04 Gabriele Micali , Robert G. Endres

Living cells employ excitable reaction-diffusion waves for internal cellular functions, in which curvature-inducing proteins are often involved. However, the role of their mechanochemical coupling is not well understood. Here, we report the…

Soft Condensed Matter · Physics 2022-08-09 Naoki Tamemoto , Hiroshi Noguchi

We show that there exist traveling wave solutions of the Keller-Segel-FKPP equation, which models a diffusing and logistically growing population subject to chemotaxis. In contrast to previous results, our result is in the strong…

Analysis of PDEs · Mathematics 2023-10-24 Christopher Henderson , Maximilian Rezek

Extending the classic works of Berg and Purcell on the biophysics of bacterial chemotaxis, we find the optimal chemotactic strategy for the peritrichous bacterium E. Coli in the high and low signal to noise ratio limits. The optimal…

adap-org · Physics 2009-10-30 S. P. Strong , B. Freedman , William Bialek , R. Koberle