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We use simple analytic arguments and lattice-based computer simulations to study the growth of structures made from a large number of distinct component types. Components possess 'designed' interactions, chosen to stabilize an equilibrium…

Soft Condensed Matter · Physics 2014-08-25 Lester O. Hedges , Ranjan V. Mannige , Stephen Whitelam

The folding of a polypeptide is an example of the cooperative effects of the amino-acid residues. Of recent interest is how a secondary structure, such as a helix, spontaneously forms during the collapse of a peptide from an initial…

Soft Condensed Matter · Physics 2016-08-31 Josh P. Kemp , Jeff Z. Y. Chen

Heterogeneous growth plays an important role in the shape and pattern formation of thin elastic structures ranging from the petals of blooming lilies to the cell walls of growing bacteria. Here we address the stability and regulation of…

Soft Condensed Matter · Physics 2018-06-05 Salem Al Mosleh , Ajay Gopinathan , Christian Santangelo

Proteins are linear chain molecules that play a central role in life and health. Protein native state folds are modular assemblies of space-filling building blocks of {\alpha}-helices, \{beta}-sheets and tight turns. Here we deduce the…

Biological Physics · Physics 2025-10-09 Jayanth R. Banavar , Achille Giacometti , Trinh X. Hoang , Amos Maritan , Tatjana Škrbić

The native state structures of globular proteins are stable and well-packed indicating that self-interactions are favored over protein-solvent interactions under folding conditions. We use this as a guiding principle to derive the geometry…

Biomolecules · Quantitative Biology 2021-07-14 Tatjana Škrbić , Amos Maritan , Achille Giacometti , George D. Rose , Jayanth R. Banavar

A novel mechanism for the production of a cosmic network of fundamental superstrings based on a time-varying string tension has been recently proposed in the context of a kinating background driven by the volume modulus of string…

High Energy Physics - Theory · Physics 2025-03-17 Luca Brunelli , Michele Cicoli , Francisco G. Pedro

We consider the evolution of a network of strings in an expanding universe, allowing for the formation of junctions between strings of different tensions. By explicitly including, in the velocity-dependent evolution equations for the…

High Energy Physics - Phenomenology · Physics 2010-04-06 A. Avgoustidis , E. J. Copeland

We investigate the statistical mechanics of long developable ribbons of finite width and very small thickness. The constraint of isometric deformations in these ribbon-like structures that follows from the geometric separation of scales…

Soft Condensed Matter · Physics 2010-06-14 L. Giomi , L. Mahadevan

We investigate the quasi-static growth of elastic fibers in the presence of dry or viscous friction. An unusual form of destabilization beyond a critical length is described. In order to characterize this phenomenon, a new definition of…

Applied Physics · Physics 2018-06-20 Marcell G. Horváth , András Á. Sipos , Péter L. Várkonyi

We develop velocity-dependent models describing the evolution of string networks that involve several types of interacting strings, each with a different tension. These incorporate the formation of Y-type junctions with links stretching…

Astrophysics · Physics 2014-11-18 A. Avgoustidis , E. P. S. Shellard

The dynamical behavior of two types of non-equilibrium systems is discussed: $(a)$ two-dimensional cellular structures, and $(b)$ living polymers. Simple models governing their evolution are introduced and steady state distributions (cell…

Condensed Matter · Physics 2007-05-23 David Mukamel

Helical ribbons arise in many biological and engineered systems, often driven by anisotropic surface stress, residual strain, and geometric or elastic mismatch between layers of a laminated composite. A full mathematical analysis is…

Mathematical Physics · Physics 2012-09-18 Zi Chen , Carmel Majidi , David J. Srolovitz , Mikko Haataja

By means of extensive replica-exchange simulations of generic coarse-grained models for helical polymers, we systematically investigate the structural transitions into all possible helical phases for flexible and semiflexible elastic…

Biological Physics · Physics 2015-09-23 Matthew J. Williams , Michael Bachmann

Carbon nanotubes and biological filaments each spontaneously assemble into kinked helices, rings, and "tennis racket" shapes due to competition between elastic and interfacial effects. We show that the slender geometry is a more important…

Soft Condensed Matter · Physics 2009-11-10 Adam E. Cohen , L. Mahadevan

We study a minimal extension of the worm-like chain to describe polypeptides having alpha-helical secondary structure. In this model presence/absence of secondary structure enters as a scalar variable that controls the local chain bending…

Statistical Mechanics · Physics 2009-11-10 Buddhapriya Chakrabarti , Alex J. Levine

We investigate the evolutionary dynamics of an idealised model for the robust self-assembly of two-dimensional structures called polyominoes. The model includes rules that encode interactions between sets of square tiles that drive the…

Populations and Evolution · Quantitative Biology 2013-09-03 Iain G. Johnston , Sebastian A. Ahnert , Jonathan P. K. Doye , Ard A. Louis

The protein folding problem has attracted an increasing attention from physicists. The problem has a flavor of statistical mechanics, but possesses the most common feature of most biological problems -- the profound effects of evolution. I…

Statistical Mechanics · Physics 2009-10-31 Chao Tang

Nascent adhesions are submicron transient structures promoting the early adhesion of cells to the extracellular matrix. Nascent adhesions typically consist of several tens of integrins, and serve as platforms for the recruitment and…

Subcellular Processes · Quantitative Biology 2021-01-19 Henning Stumpf , Andreja Ambriović-Ristov , Aleksandra Radenovic , Ana-Sunčana Smith

We study the dynamics of proliferating cell collectives whose microscopic constituents' growth is inhibited by macroscopic growth-induced stress. Discrete particle simulations of a growing collective show the emergence of concentric-ring…

Biological Physics · Physics 2024-05-17 Scott Weady , Bryce Palmer , Adam Lamson , Taeyoon Kim , Reza Farhadifar , Michael J. Shelley

Motivated by the formation of ring-like filament structures in the cortex of plant and animal cells, we study the dynamics of a two-dimensional layer of cytoskeletal filaments and motor proteins near a surface by a general continuum theory.…

Subcellular Processes · Quantitative Biology 2009-11-11 Alexander Zumdieck , Marco Cosentino Lagomarsino , Catalin Tanase , Karsten Kruse , Bela Mulder , Marileen Dogterom , Frank J"ulicher
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