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Rhythmic and sequential segmentation of the embryonic body plan is a vital developmental patterning process in all vertebrate species. However, a theoretical framework capturing the emergence of dynamic patterns of gene expression from the…

Biological Physics · Physics 2016-10-12 David J. Jörg , Andrew C. Oates , Frank Jülicher

Recently described stochastic models of protein evolution have demonstrated that the inclusion of structural information in addition to amino acid sequences leads to a more reliable estimation of evolutionary parameters. We present a…

Populations and Evolution · Quantitative Biology 2020-09-22 Michael Golden , Eduardo García-Portugués , Michael Sørensen , Kanti V. Mardia , Thomas Hamelryck , Jotun Hein

While all the information required for the folding of a protein is contained in its amino acid sequence, one has not yet learned how to extract this information to predict the three--dimensional, biologically active, native conformation of…

Biomolecules · Quantitative Biology 2009-11-10 R. A. Broglia , G. Tiana

We investigate percolation on growing networks where the evolution of connected components resembles a non-equilibrium version of the multiplicative coalescent. The supercritical $\pi> \pi_c$ regime for a host of such models was conjectured…

Probability · Mathematics 2025-12-18 Sayan Banerjee , Shankar Bhamidi , Remco van der Hofstad , Rounak Ray

Differentiating structural evolution from structural development or formation opens many avenues of research. The study particularly advances the chemical and physical sciences, material science, energy science, and chemical engineering. By…

Materials Science · Physics 2025-12-30 Mubarak Ali

We argue that protein native state structures reside in a novel "phase" of matter which confers on proteins their many amazing characteristics. This phase arises from the common features of all globular proteins and is characterized by a…

Biomolecules · Quantitative Biology 2012-04-13 Jayanth R. Banavar , Trinh X. Hoang , Flavio Seno , Antonio Trovato , Amos Maritan

Proteins need to selectively interact with specific targets among a multitude of similar molecules in the cell. But despite a firm physical understanding of binding interactions, we lack a general theory of how proteins evolve high…

Biomolecules · Quantitative Biology 2022-09-28 John M McBride , Jean-Pierre Eckmann , Tsvi Tlusty

A novel mechanism to produce a cosmic network of fundamental superstrings based on a time-varying string tension has been recently proposed. It has been found that fundamental superstrings can grow in a kinating background driven by the…

High Energy Physics - Theory · Physics 2025-11-24 Luca Brunelli

Many organisms exhibit branching morphologies that twist around each other and become entangled. Entanglement occurs when different objects interlock, creating complex and often irreversible configurations. This physical phenomenon is…

Helical structures, almost ubiquitous in biological systems, have inspired the design and manufacturing of helical devices with applications in nanoelecromechanical systems (NEMS), morphing structures, optoelectronics, micro-robotics and…

Soft Condensed Matter · Physics 2015-06-18 Qiaohang Guo , Anil K. Mehta , Martha A. Grover , Wenzhe Chen , David G. Lynn , Zi Chen

By adding minute concentrations of a high molecular weight polymer, liquid jets or bridges collapsing under the action of surface tension develop a characteristic shape of uniform threads connecting spherical fluid drops. In this paper,…

Materials Science · Physics 2007-05-23 C. Clasen , J. Eggers , M. A. Fontelos , J. Li , G. H. McKinley

We present a sequence-based probabilistic formalism that directly addresses co-operative effects in networks of interacting positions in proteins, providing significantly improved contact prediction, as well as accurate quantitative…

Quantitative Methods · Quantitative Biology 2012-07-12 Alan Lapedes , Bertrand Giraud , Christopher Jarzynski

Theories of phase change and self-assembly often invoke the idea of a `quasiequilibrium', a regime in which the nonequilibrium association of building blocks results nonetheless in a structure whose properties are determined solely by an…

Statistical Mechanics · Physics 2013-07-22 Stephen Whitelam , Rebecca Schulman , Lester Hedges

The three-dimensional shapes of thin lamina such as leaves, flowers, feathers, wings etc, are driven by the differential strain induced by the relative growth. The growth takes place through variations in the Riemannian metric, given on the…

Analysis of PDEs · Mathematics 2014-01-09 Marta Lewicka , L. Mahadevan , Mohammad Reza Pakzad

We demonstrate the emergence of self-organized structures in the course of the relaxation of an initially excited, dissipative and finite chain of interacting particles in a periodic potential towards its many particle equilibrium…

Adaptation and Self-Organizing Systems · Physics 2016-08-19 Benno Liebchen , Peter Schmelcher

The dynamics of string junctions and their influence on the evolution of cosmic superstring networks are studied in full detail. We review kinematic constraints for colliding strings in a Friedmann-Lema\^itre-Robertson-Walker background and…

Cosmology and Nongalactic Astrophysics · Physics 2019-03-27 I. Yu. Rybak , A. Avgoustidis , C. J. A. P. Martins

Nested structure, which is non-random, controls cooperation dynamics and biodiversity in plant-animal mutualistic networks. This structural pattern has been explained in a static (non-growth) network models. However, evolutionary processes…

Populations and Evolution · Quantitative Biology 2015-03-19 Kazuhiro Takemoto , Masanori Arita

A fundamental problem in protobiological dynamics is to understand how chemically generated polymers can form persistent sequence distributions before the emergence of replication. We study deterministic polymer growth in which each finite…

Populations and Evolution · Quantitative Biology 2026-05-06 J. Medina Diaz , F. Peña-Garcia , Irbin Llanqui

Complex systems have motivated continuing interest from the scientific community, leading to new concepts and methods. Growing systems represent a case of particular interest, as their topological, geometrical, and also dynamical properties…

Social and Information Networks · Computer Science 2024-05-27 Alexandre Benatti , Roberto M. Cesar , Luciano da F. Costa

If a semiflexible polymer confined to a narrow channel bends around by 180 degrees, the polymer is said to exhibit a hairpin. The equilibrium extension statistics of the confined polymer are well understood when hairpins are vanishingly…