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We introduce a temporal scheme for data sampling, based on a variable delay between two successive data acquisitions. The scheme is designed so as to reduce the average data flow rate, while still retaining the information on the data…

Soft Condensed Matter · Physics 2016-08-06 A. Philippe , S. Aime , V. Roger , R. Jelinek , G. Prévot , L. Berthier , L. Cipelletti

The study of rare events is one of the major challenges in atomistic simulations, and several enhanced sampling methods towards its solution have been proposed. Recently, it has been suggested that the use of the committor, which provides a…

Computational Physics · Physics 2025-10-23 Peilin Kang , Jintu Zhang , Enrico Trizio , TingJun Hou , Michele Parrinello

From Physics and Biology to Seismology and Economics, the behaviour of countless systems is determined by impactful yet unlikely transitions between metastable states known as \emph{rare events}, the study of which is essential for…

Computational Physics · Physics 2025-07-22 Solomon Asghar , Qing-Xiang Pei , Giorgio Volpe , Ran Ni

We study a random matrix model for the statistical properties of the purity of a bipartite quantum system at a finite (fictitious) temperature. This enables us to write the generating function for the cumulants, for both balanced and…

Quantum Physics · Physics 2010-01-30 P. Facchi , U. Marzolino , G. Parisi , S. Pascazio , A. Scardicchio

A novel and powerful method is presented for the study of rare switching events in complex systems with multiscale energy landscapes. The method performs an umbrella sampling of the equilibrium distribution of the system in hyperplanes…

Condensed Matter · Physics 2007-05-23 Weinan E , Weiqing Ren , Eric Vanden-Eijnden

We present an efficient method to compute transition rates between states for a two-state system. The method utilizes the equivalence between steady-state flux and mean first passage rate for such systems. More specifically, the procedure…

Biological Physics · Physics 2011-09-06 Divesh Bhatt , Ivet Bahar

Simulations with an adaptive time-dependent bias, such as metadynamics, enable an efficient exploration of the conformational space of a system. However, the dynamic information of the system is altered by the bias. With infrequent…

Simulation experiments are typically conducted repeatedly during the model development process, for example, to re-validate if a behavioral property still holds after several model changes. Approaches for automatically reusing and…

Computational Engineering, Finance, and Science · Computer Science 2021-09-15 Pia Wilsdorf , Anja Wolpers , Jason Hilton , Fiete Haack , Adelinde M. Uhrmacher

The study by Jung et al. (Jung H, Covino R, Arjun A, et al., Nat Comput Sci. 3:334-345 (2023)) introduced Artificial Intelligence for Molecular Mechanism Discovery (AIMMD), a novel sampling algorithm that integrates machine learning to…

Computational Physics · Physics 2026-02-06 Porhouy Minh , Sapna Sarupria

We investigate the utility to computational Bayesian analyses of a particular family of recursive marginal likelihood estimators characterized by the (equivalent) algorithms known as "biased sampling" or "reverse logistic regression" in the…

Methodology · Statistics 2014-10-16 Ewan Cameron , Anthony Pettitt

We introduce a simulation model of the port of Calais with a focus on the operation of immigration controls. Our aim is to compare the cost and benefits of different screening policies. Methodologically, we are trying to understand the…

Computational Engineering, Finance, and Science · Computer Science 2013-06-24 Galina Sherman , David Menachof , Peer-Olaf Siebers , Uwe Aickelin

The objective of this work is to develop a method for detecting rare gamma quanta against the background of charged particles in the fluxes from sources in the Universe with the help of the deep learning and normalizing flows based method…

Instrumentation and Methods for Astrophysics · Physics 2025-10-24 A. P. Kryukov , A. Yu. Razumov , A. P. Demichev , J. J. Dubenskaya , E. O. Gres , S. P. Polyakov , E. B. Postnikov , P. A. Volchugov , D. P. Zhurov

Computing the return times of extreme events and assessing the impact of climate change on such return times is fundamental to extreme event attribution studies. However, the rarity of such events in the observational record makes this task…

Atmospheric and Oceanic Physics · Physics 2024-12-03 Clément Le Priol , Joy M. Monteiro , Freddy Bouchet

In many dynamical systems there is a large separation of time scales between typical events and "rare" events which can be the cases of interest. Rare-event rates are quite difficult to compute numerically, but they are of considerable…

Statistical Mechanics · Physics 2015-05-19 David A. Adams , Leonard M. Sander , Robert M. Ziff

Molecular dynamics simulations are widely used across chemistry, physics, and biology, providing quantitative insight into complex processes with atomic detail. However, their limited timescale of a few microseconds is a significant…

Chemical Physics · Physics 2025-04-10 Ofir Blumer , Barak Hirshberg

The interplay between stochastic chemical reactions and diffusion can generate rich spatiotemporal patterns. While the timescale for individual reaction or diffusion events may be very fast, the timescales for organization can be much…

Statistical Mechanics · Physics 2023-12-12 Schuyler B. Nicholson , Todd R. Gingrich

Rare events can potentially occur in many applications. When manifested as opportunities to be exploited, risks to be ameliorated, or certain features to be extracted, such events become of paramount significance. Due to their sporadic…

Information Theory · Computer Science 2012-10-10 Ali Tajer , H. Vincent Poor

Branching processes are a class of continuous-time Markov chains (CTMCs) with ubiquitous applications. A general difficulty in statistical inference under partially observed CTMC models arises in computing transition probabilities when the…

Computation · Statistics 2015-03-10 Jason Xu , Vladimir N. Minin

Forward flux sampling (FFS) provides a convenient and efficient way to simulate rare events in equilibrium or non-equilibrium systems. FFS ratchets the system from an initial state to a final state via a series of interfaces in phase space.…

Chemical Physics · Physics 2015-06-15 Kai Kratzer , Axel Arnold , Rosalind J. Allen

We propose an adaptive importance sampling scheme for the simulation of rare events when the underlying dynamics is given by a diffusion. The scheme is based on a Gibbs variational principle that is used to determine the optimal (i.e.…

Probability · Mathematics 2019-07-24 Carsten Hartmann , Omar Kebiri , Lara Neureither , Lorenz Richter
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