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Near-infrared (NIR) hyperspectral imaging is widely used to reveal morphological and chemical information. However, conventional spectral imagers usually rely on costly focal plane arrays and suffer from data redundancy and inefficiencies…

Optics · Physics 2026-05-26 Ben Sun , Kun Huang , Zhibin Zhao , Beibei Dong , Jianan Fang , Heping Zeng

Fourier-transform infrared spectroscopy (FTIR) is an indispensable analytical method that allows label-free identification of substances via fundamental molecular vibrations. However, the sensitivity of FTIR is often limited by the low…

Multispectral mid-infrared (2-5 ${{\mu}m}$) imaging is a critical capability across science and technology, offering a window into the vibrational and thermal landscape of matter that is inaccessible to visible sensors. It bridges the…

Optics · Physics 2026-01-29 Daniel Beitner , Ziv Abelson , Eyal Hollander , Omri Meron , Haim Suchowski

Efficient and selective excitation of lattice vibrations is central to controlling energy flow at the nanoscale, yet remains challenging under conventional optical excitation. Here, we introduce a mid-infrared-assisted phonon amplification…

Applied Physics · Physics 2026-05-15 Christopher Sumner , Jakob Ziewer , Anju Sajan , Fumin Huang , Rohit Chikkaraddy

Mid-infrared photothermal (MIP) microscopy has been a promising label-free chemical imaging technique for functional characterization of specimens owing to its enhanced spatial resolution and high specificity. Recently developed wide-field…

Spectral imaging and detection of mid-infrared (mid-IR) wavelengths are emerging as an enabling technology of great technical and scientific interest; primarily because important chemical compounds display unique and strong mid-IR spectral…

Single-photon laser ranging has widespread applications in remote sensing and target recognition. However, highly-sensitive light detection and ranging (LiDAR) has long been restricted in visible or near-infrared bands. An appealing quest…

Mid-infrared (MIR) detectors find extensive applications in chemical sensing, spectroscopy, communications, biomedical diagnosis and space explorations. Alternative to semiconductor MIR photodiodes and bolometers, mechanical-resonator-based…

Ovarian cancer detection has traditionally relied on a multi-step process that includes biopsy, tissue staining, and morphological analysis by experienced pathologists. While widely practiced, this conventional approach suffers from several…

Mid-InfraRed spectroscopy is a promising label-free technique that can offer insights into morphological and pathological alterations in biological tissues at the molecular level. Owing to the development of the Fourier Transform InfraRed…

Optics · Physics 2026-04-21 Xiangyu Zhao , Yudong Tian , Jingzhu Shao , Chongzhao Wu

Owing to its capacity for unique (bio)-chemical specificity, microscopy withmid-IR illumination holds tremendous promise for a wide range of biomedical and industrial applications. The primary limitation, however, remains detection; with…

Mid-wave infrared (MWIR) cameras for large number pixels are extremely expensive compared with their counterparts in visible light, thus, super-resolution imaging (SRI) for MWIR by increasing imaging pixels has always been a research…

Image and Video Processing · Electrical Eng. & Systems 2025-03-19 Xiao-Peng Jin , Qing Zhao , Xue-Feng Liu , An-Dong Xiong

Sensitive mid-infrared (MIR) detection is highly demanded in various applications, ranging from remote sensing, infrared surveillance, environmental monitoring to industrial inspection. Among others, upconversion infrared detectors have…

Optics · Physics 2026-05-29 Xiaohan Liu , Kun Huang , Wen Zhang , Ben Sun , Jianan Fang , Yan Liang , Heping Zeng

Sensing with undetected photons has become a vibrant, application-driven research domain with a special focus on the mid-infrared (mid-IR) wavelength region. Since the mid-IR contains spectral bands with highly specific and strong molecular…

Waveguide-integrated mid-infrared (MIR) photodetectors are pivotal components for the development of molecular spectroscopy applications, leveraging mature photonic integrated circuit (PIC) technologies. Despite various strategies, critical…

Entangled two-photon absorption spectroscopy (TPA) has been widely recognized as a powerful tool for revealing relevant information about the structure of complex molecular systems. However, to date, the experimental implementation of this…

Quantum Physics · Physics 2019-07-10 Roberto de J. León-Montiel , Jiří Svozilík , Juan P. Torres , Alfred B. U'Ren

High-resolution chemical imaging within deep tissues and intact spheroids remains a grand challenge. Here, we introduce mid-wave infrared photothermal (MWIP) microscopy operating in the underexplored 2000-2500 nm spectral window for…

Minfrared spectroscopic imaging (MIRSI) is an emerging class of label-free, biochemically quantitative technologies targeting digital histopathology. Conventional histopathology relies on chemical stains that alter tissue color. This…

Image and Video Processing · Electrical Eng. & Systems 2022-07-26 Mahsa Lotfollahi , Nguyen Tran , Sebastian Berisha , Chalapathi Gajjela , Zhu Han , David Mayerich , Rohith Reddy

High-order edge-enhanced imaging enables precise feature localization and effective background suppression, offering a powerful tool for real-time recognition and high-contrast visualization. Extending this capability to the mid-infrared…

Optics · Physics 2026-05-14 Jixi Zhang , Kun Huang , Shina Liao , Zhuohang Wei , Jianan Fang , Heping Zeng

The mid-infrared (MIR) spectral range, pertaining to important applications such as molecular 'fingerprint' imaging, remote sensing, free space telecommunication and optical radar, is of particular scientific interest and technological…