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In medical image analysis, the expertise scarcity and the high cost of data annotation limits the development of large artificial intelligence models. This paper investigates the potential of transfer learning with pre-trained…

Computer Vision and Pattern Recognition · Computer Science 2024-05-27 Jiajin Zhang , Ge Wang , Mannudeep K. Kalra , Pingkun Yan

Large Language Models (LLMs) based agents excel at diverse tasks, yet they suffer from brittle procedural memory that is manually engineered or entangled in static parameters. In this work, we investigate strategies to endow agents with a…

Computation and Language · Computer Science 2026-04-16 Runnan Fang , Yuan Liang , Xiaobin Wang , Jialong Wu , Shuofei Qiao , Pengjun Xie , Fei Huang , Huajun Chen , Ningyu Zhang

Medical problem-solving demands expert knowledge and intricate reasoning. Recent studies of large language models (LLMs) attempt to ease this complexity by introducing external knowledge verification through retrieval-augmented generation…

Computation and Language · Computer Science 2026-01-19 Yue Huang , Yanyuan Chen , Dexuan Xu , Chenzhuo Zhao , Weihua Yue , Yu Huang

While current large language models (LLMs) perform well on many knowledge-related tasks, they are limited by relying on their parameters as an implicit storage mechanism. As a result, they struggle with memorizing rare events and with…

Computation and Language · Computer Science 2025-04-18 Ali Modarressi , Abdullatif Köksal , Ayyoob Imani , Mohsen Fayyaz , Hinrich Schütze

Medical vision-language pretraining (VLP) that leverages naturally-paired medical image-report data is crucial for medical image analysis. However, existing methods struggle to accurately characterize associations between images and…

Computer Vision and Pattern Recognition · Computer Science 2025-01-22 Xinjie Liang , Xiangyu Li , Fanding Li , Jie Jiang , Qing Dong , Wei Wang , Kuanquan Wang , Suyu Dong , Gongning Luo , Shuo Li

Recent advances in generative medical models are constrained by modality-specific scenarios that hinder the integration of complementary evidence from imaging, pathology, and clinical notes. This fragmentation limits their evolution into…

Computer Vision and Pattern Recognition · Computer Science 2025-10-08 Jiawei Mao , Yuhan Wang , Lifeng Chen , Can Zhao , Yucheng Tang , Dong Yang , Liangqiong Qu , Daguang Xu , Yuyin Zhou

Large language models suffer from knowledge staleness and lack of interpretability due to implicit knowledge storage across entangled network parameters, preventing targeted updates and reasoning transparency. We propose ExplicitLM, a novel…

Artificial Intelligence · Computer Science 2025-11-04 Chengzhang Yu , Zening Lu , Chenyang Zheng , Chiyue Wang , Yiming Zhang , Zhanpeng Jin

Building trustworthy clinical AI systems requires not only accurate predictions but also transparent, biologically grounded explanations. We present \texttt{DiagnoLLM}, a hybrid framework that integrates Bayesian deconvolution, eQTL-guided…

Artificial Intelligence · Computer Science 2025-11-18 Bowen Xu , Xinyue Zeng , Jiazhen Hu , Tuo Wang , Adithya Kulkarni

Vision-Language Models (VLMs) have enabled interpretable medical diagnosis by integrating visual perception with linguistic reasoning. Yet, existing medical chain-of-thought (CoT) models lack explicit mechanisms to represent and enforce…

Artificial Intelligence · Computer Science 2026-05-29 Jianxin Lin , Chunzheng Zhu , Peter J. Kneuertz , Yunfei Bai , Yuan Xue

An accurate differential diagnosis (DDx) is a cornerstone of medical care, often reached through an iterative process of interpretation that combines clinical history, physical examination, investigations and procedures. Interactive…

As LLM agents scale to long-horizon, multi-session deployments, efficiently managing accumulated experience becomes a critical bottleneck. Agent memory systems and agent skill discovery both address this challenge -- extracting reusable…

Artificial Intelligence · Computer Science 2026-04-20 Xing Zhang , Guanghui Wang , Yanwei Cui , Wei Qiu , Ziyuan Li , Bing Zhu , Peiyang He

Medical vision-language models (VLMs) show strong performance on radiology tasks but often produce fluent yet weakly grounded conclusions due to over-reliance on a dominant modality. We introduce a context-aligned reasoning framework that…

Computer Vision and Pattern Recognition · Computer Science 2026-04-13 Sumra Khan , Sagar Chhabriya , Aizan Zafar , Sheeraz Arif , Amgad Muneer , Anas Zafar , Shaina Raza , Rizwan Qureshi

Large audio language models (LALMs) process both speech and environmental acoustic cues, yet struggle to retain non-speech information across multi-turn interactions. The performance gap between semantic (speech) and acoustic (non-speech)…

Audio and Speech Processing · Electrical Eng. & Systems 2026-05-27 Yang Xiao , Siyi Wang , Han Yin , Hong Jia , Vidhyasaharan Sethu , Eun-Jung Holden , Ting Dang

Recently, Vision Large Language Models (VLMs) have demonstrated high potential in computer-aided diagnosis and decision-support. However, current VLMs show deficits in domain specific surgical scene understanding, such as identifying and…

Computer Vision and Pattern Recognition · Computer Science 2025-12-08 Lennart Maack , Julia-Kristin Graß , Lisa-Marie Toscha , Nathaniel Melling , Alexander Schlaefer

Large Language Models (LLMs) have made significant progress in various fields. However, challenges remain in Multi-Disciplinary Team (MDT) medical consultations. Current research enhances reasoning through role assignment, task…

Artificial Intelligence · Computer Science 2025-03-19 Kai Chen , Xinfeng Li , Tianpei Yang , Hewei Wang , Wei Dong , Yang Gao

Recent developments in Large Language Model (LLM)-based agents have shown impressive capabilities spanning multiple domains, exemplified by deep research systems that demonstrate superior performance on complex information-seeking and…

Computation and Language · Computer Science 2025-09-03 Ailing Yu , Lan Yao , Jingnan Liu , Zhe Chen , Jiajun Yin , Yuan Wang , Xinhao Liao , Zhiling Ye , Ji Li , Yun Yue , Hansong Xiao , Hualei Zhou , Chunxiao Guo , Peng Wei , Junwei Liu , Jinjie Gu

Medical vision language pre-training (VLP) has emerged as a frontier of research, enabling zero-shot pathological recognition by comparing the query image with the textual descriptions for each disease. Due to the complex semantics of…

Computer Vision and Pattern Recognition · Computer Science 2024-04-02 Vu Minh Hieu Phan , Yutong Xie , Yuankai Qi , Lingqiao Liu , Liyang Liu , Bowen Zhang , Zhibin Liao , Qi Wu , Minh-Son To , Johan W. Verjans

Pathology context and expert experience play significant roles in clinical ocular disease diagnosis. Although deep neural networks (DNNs) have good ocular disease recognition results, they often ignore exploring the clinical pathology…

Computer Vision and Pattern Recognition · Computer Science 2026-01-01 Zunjie Xiao , Xiaoqing Zhang , Risa Higashita , Jiang Liu

Retrieving visual and textual information from medical literature and hospital records can enhance diagnostic accuracy for clinical image interpretation. However, multimodal retrieval-augmented diagnosis is highly challenging. We explore a…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Nir Mazor , Tom Hope

Timely and accurate diagnosis of neurodegenerative disorders, such as Alzheimer's disease, is central to disease management. Existing deep learning models require large-scale annotated datasets and often function as "black boxes".…

Computer Vision and Pattern Recognition · Computer Science 2025-04-15 Duy-Cat Can , Quang-Huy Tang , Huong Ha , Binh T. Nguyen , Oliver Y. Chén