Related papers: A Solid-state Sub-nm Pore for Single-mer Resolutio…
In nanopore sequencing, electrical signal is measured as DNA molecules pass through the sequencing pores. Translating these signals into DNA bases (base calling) is a highly non-trivial task, and its quality has a large impact on the…
Reconfigurable photonic devices are rapidly emerging as a cornerstone of next generation optical technologies, with wide ranging applications in quantum simulation, neuromorphic computing, and large-scale photonic processors. A central…
Two-photon polymerization (2PP) 3D printing is a well-known technique for fabricating passive micro/nanoscale structures, such as microlenses and inversely designed polarization splitters. The integration of light emitting nanoparticle (NP)…
We present a Solid-State Optical Magnetometer (SOM) based on black phosphorus (BP) multilayers, offering a compact, scalable, and highly sensitive alternative to traditional atomic-based magnetometers. Utilizing BP's intrinsic linear…
Nanosize pores can turn semimetallic graphene into a semiconductor and from being impermeable into the most efficient molecular sieve membrane. However, scaling the pores down to the nanometer, while fulfilling the tight structural…
Solid-state nanopores are emerging platforms for single-molecule protein sequencing due to their tolerance to hash physiology environment and compatibility with different electrical and optical detection methods. However, they suffer from…
Surface plasmon resonances (SPRs) are crucial for confining light beyond the diffraction limit, yet heavy metal losses often limit their spectral localization. Here, we propose a practical strategy for enabling the spectral localization of…
Fast, reliable and inexpensive DNA sequencing is an important pursuit in healthcare, especially in personalized medicine with possible deep societal impacts. Despite significant progress of various nanopore-based sequencing configurations,…
Microscopy has been key to tremendous advances in science, technology, and medicine, revealing structure and dynamics across time and length scales. However, combining high spatial and temporal resolution in a non-invasive, label-free…
Photon number-resolving detectors (PNRDs) are the ultimate optical sensors. Superconducting-nanostrip photon detectors (SNSPDs), traditionally known as ON-OFF detectors, have recently been found to have photon number resolving capability…
Sequential pattern mining (SPM) has excellent prospects and application spaces and has been widely used in different fields. The non-overlapping SPM, as one of the data mining techniques, has been used to discover patterns that have…
Nanopore protein sequencing produces long, noisy ionic current traces in which key molecular phases, such as protein capture and translocation, are embedded. Capture phases mark the successful entry of a protein into the pore and serve as…
Nitrogen Vacancy diamond nanoparticles (NVNPs) are increasingly integrated with methods for optical detection of magnetic resonance (ODMR), providing new opportunities in magnetic characterization that span the visualization of magnetic…
Hand-sized Deoxyribonucleic acid (DNA) sequencing machines are of growing importance in several life sciences fields as their small footprints enable a broader range of use cases than their larger, stationary counterparts. However, as…
Thin membranes are highly sought-after for nanopore-based single-molecule sensing and fabrication of such membranes becomes challenging in the \lesssim10 nm thickness regime where a plethora of useful molecule information can be acquired by…
A tandem cell is proposed for DNA sequencing in which an exonuclease enzyme cleaves bases (mononucleotides) from a strand of DNA for identification inside a nanopore. It has two nanopores and three compartments with the structure [cis1,…
The determination of a patient's DNA sequence can, in principle, reveal an increased risk to fall ill with particular diseases [1,2] and help to design "personalized medicine" [3]. Moreover, statistical studies and comparison of genomes [4]…
DNA nanotechnology uses predictable interactions of nucleic acids to precisely engineer complex nanostructures. Characterizing these self-assembled structures at the single-structure level is crucial for validating their design and…
We study voltage driven translocation of a single stranded (ss) DNA through a membrane channel. Our model, based on a master equation (ME) approach, investigates the probability density function (pdf) of the translocation times, and shows…
The rapid expansion of generative AI drives unprecedented demands for high-performance computing. Training large-scale AI models now requires vast interconnected GPU clusters across multiple data centers. Multi-scale AI training and…