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The emergence of Self-Driving Laboratories (SDLs) transforms scientific discovery methodology by integrating AI with robotic automation to create closed-loop experimental systems capable of autonomous hypothesis generation, experimentation,…

Robotics · Computer Science 2026-02-18 Zihan Zhang , Haohui Que , Junhan Chang , Xin Zhang , Hao Wei , Tong Zhu

Thorough testing of safety-critical autonomous systems, such as self-driving cars, autonomous robots, and drones, is essential for detecting potential failures before deployment. One crucial testing stage is model-in-the-loop testing, where…

Robotics · Computer Science 2023-01-04 Dmytro Humeniuk , Foutse Khomh , Giuliano Antoniol

Systematic literature reviews (SLRs) are fundamental to evidence-based research, but manual screening is an increasing bottleneck as scientific output grows. Screening features low prevalence of relevant studies and scarce, costly expert…

Machine Learning · Computer Science 2026-02-06 Parsa Vares

Current Autonomous Scientific Research (ASR) systems, despite leveraging large language models (LLMs) and agentic architectures, remain constrained by fixed workflows and toolsets that prevent adaptation to evolving tasks and environments.…

Artificial Intelligence · Computer Science 2026-04-01 Martin Legrand , Tao Jiang , Matthieu Feraud , Benjamin Navet , Yousouf Taghzouti , Fabien Gandon , Elise Dumont , Louis-Félix Nothias

Humans naturally adapt to diverse environments by learning underlying rules across worlds with different dynamics, observations, and reward structures. In contrast, existing agents typically demonstrate improvements via self-evolving within…

Large Language Model (LLM) agents are increasingly improved through interaction, yet most self-evolution methods adapt either the policy or the learning environment in isolation. We identify this structural gap as \emph{Agent-Environment…

Computation and Language · Computer Science 2026-05-26 Yihao Hu , Zhihao Wen , Xiujin Liu , Pan Wang , Xin Zhang , Wei Wu

LLM agents increasingly operate in open-ended environments spanning hundreds of sequential episodes, yet they remain largely stateless: each task is solved from scratch without converting past experience into better future behavior. The…

Computation and Language · Computer Science 2026-04-24 Wujiang Xu , Jiaojiao Han , Minghao Guo , Kai Mei , Xi Zhu , Han Zhang , Dimitris N. Metaxas

The hallmark of human intelligence is the self-evolving ability to master new skills by learning from past experiences. However, current AI agents struggle to emulate this self-evolution: fine-tuning is computationally expensive and prone…

Computation and Language · Computer Science 2026-02-13 Shengtao Zhang , Jiaqian Wang , Ruiwen Zhou , Junwei Liao , Yuchen Feng , Zhuo Li , Yujie Zheng , Weinan Zhang , Ying Wen , Zhiyu Li , Feiyu Xiong , Yutao Qi , Bo Tang , Muning Wen

Agentic reinforcement learning has advanced large language models (LLMs) to reason through long chain-of-thought trajectories while interleaving external tool use. Existing approaches assume a fixed inventory of tools, limiting LLM agents'…

Computation and Language · Computer Science 2025-12-16 Jiaru Zou , Ling Yang , Yunzhe Qi , Sirui Chen , Mengting Ai , Ke Shen , Jingrui He , Mengdi Wang

Reinforcement learning (RL) provides a naturalistic framing for learning through trial and error, which is appealing both because of its simplicity and effectiveness and because of its resemblance to how humans and animals acquire skills…

Machine Learning · Computer Science 2022-08-09 Archit Sharma , Kelvin Xu , Nikhil Sardana , Abhishek Gupta , Karol Hausman , Sergey Levine , Chelsea Finn

In contemporary biomedical research, the efficiency of data-driven approaches is hindered by large data volumes, tool selection complexity, and human resource limitations, necessitating the development of fully autonomous research systems…

Quantitative Methods · Quantitative Biology 2024-08-13 Luojia Deng , Yijie Wu , Yongyong Ren , Hui Lu

The Retrieval-Augmented Language Model (RALM) has shown remarkable performance on knowledge-intensive tasks by incorporating external knowledge during inference, which mitigates the factual hallucinations inherited in large language models…

Computation and Language · Computer Science 2024-12-20 Yuan Xia , Jingbo Zhou , Zhenhui Shi , Jun Chen , Haifeng Huang

Today's AI systems have human-designed, fixed architectures and cannot autonomously and continuously improve themselves. The advance of AI could itself be automated. If done safely, that would accelerate AI development and allow us to reap…

Artificial Intelligence · Computer Science 2026-03-16 Jenny Zhang , Shengran Hu , Cong Lu , Robert Lange , Jeff Clune

Artificial intelligence research increasingly depends on prolonged cycles of reproduction, debugging, and iterative refinement to achieve State-Of-The-Art (SOTA) performance, creating a growing need for systems that can accelerate the full…

LLM-powered multi-agent systems can now automate the full research pipeline from ideation to paper writing, but a fundamental question remains: automation for whom? Researchers operate under different resource configurations, hold different…

Artificial Intelligence · Computer Science 2026-05-18 Jinhang Xu , Qiyuan Zhu , Yujun Wu , Zirui Wang , Dongxu Zhang , Marcia Tian , Yiling Duan , Siyuan Li , Jingxuan Wei , Sirui Han , Yike Guo , Odin Zhang , Conghui He , Cheng Tan

It is expected that many human drivers will still prefer to drive themselves even if the self-driving technologies are ready. Therefore, human-driven vehicles and autonomous vehicles (AVs) will coexist in a mixed traffic for a long time. To…

Robotics · Computer Science 2019-10-14 Dong Chen , Longsheng Jiang , Yue Wang , Zhaojian Li

Machine learning and deep learning-based decision making has become part of today's software. The goal of this work is to ensure that machine learning and deep learning-based systems are as trusted as traditional software. Traditional…

Autonomous vehicles must remain safe and effective when encountering rare long-tailed scenarios or cyber-physical intrusions during driving. We present RAIL, a risk-aware human-in-the-loop framework that turns heterogeneous runtime signals…

Artificial Intelligence · Computer Science 2026-01-21 Dawood Wasif , Terrence J. Moore , Seunghyun Yoon , Hyuk Lim , Dan Dongseong Kim , Frederica F. Nelson , Jin-Hee Cho

Large-scale scientific datasets -- spanning health biobanks, cell atlases, Earth reanalyses, and more -- create opportunities for exploratory discovery unconstrained by specific research questions. We term this process hypothesis hunting:…

Artificial Intelligence · Computer Science 2025-10-13 Tennison Liu , Silas Ruhrberg Estévez , David L. Bentley , Mihaela van der Schaar

We present AlphaLab, an autonomous research harness that leverages frontier LLM agentic capabilities to automate the full experimental cycle in quantitative, computation-intensive domains. Given only a dataset and a natural-language…