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Understanding how cellular morphology, gene expression, and spatial context jointly shape tissue function is a central challenge in biology. Image-based spatial transcriptomics technologies now provide high-resolution measurements of cell…

Quantitative Methods · Quantitative Biology 2026-02-17 Zhenglun Kong , Mufan Qiu , John Boesen , Xiang Lin , Sukwon Yun , Tianlong Chen , Manolis Kellis , Marinka Zitnik

Intra-cardiac Echocardiography (ICE) plays a crucial role in Electrophysiology (EP) and Structural Heart Disease (SHD) interventions by providing high-resolution, real-time imaging of cardiac structures. However, existing navigation methods…

Image and Video Processing · Electrical Eng. & Systems 2025-05-14 Jaeyoung Huh , Ankur Kapoor , Young-Ho Kim

Wasserstein GANs with Gradient Penalty (WGAN-GP) are a very popular method for training generative models to produce high quality synthetic data. While WGAN-GP were initially developed to calculate the Wasserstein 1 distance between…

Machine Learning · Computer Science 2022-07-01 Tristan Milne , Adrian Nachman

When the data are stored in a distributed manner, direct application of traditional statistical inference procedures is often prohibitive due to communication cost and privacy concerns. This paper develops and investigates two…

Machine Learning · Statistics 2021-08-04 Jianqing Fan , Yongyi Guo , Kaizheng Wang

Accessing the network through which a propagation dynamics diffuse is essential for understanding and controlling it. In a few cases, such information is available through direct experiments or thanks to the very nature of propagation data.…

Physics and Society · Physics 2020-12-15 Alfredo Braunstein , Alessandro Ingrosso , Anna Paola Muntoni

Many imaging techniques for biological systems -- like fixation of cells coupled with fluorescence microscopy -- provide sharp spatial resolution in reporting locations of individuals at a single moment in time but also destroy the dynamics…

Subcellular Processes · Quantitative Biology 2024-05-15 Christopher E. Miles , Scott A. McKinley , Fangyuan Ding , Richard B. Lehoucq

In this paper the space of images is considered as a Riemannian manifold using the metamorphosis approach, where the underlying Riemannian metric simultaneously measures the cost of image transport and intensity variation. A robust and…

Numerical Analysis · Mathematics 2015-05-28 Benjamin Berkels , Alexander Effland , Martin Rumpf

Despite recent advances in human pose estimation (HPE), poor generalization to out-of-distribution (OOD) data remains a difficult problem. While previous works have proposed Test-Time Adaptation (TTA) to bridge the train-test domain gap by…

Computer Vision and Pattern Recognition · Computer Science 2024-07-23 Luke Bidulka , Mohsen Gholami , Jiannan Zheng , Martin J. McKeown , Z. Jane Wang

Aircraft failures alter dynamics, diminishing manoeuvrability. Such manoeuvring flight envelope variations, governed by the aircraft's complex nonlinear dynamics, are unpredictable by pilots and existing flight management systems. To…

Systems and Control · Electrical Eng. & Systems 2024-08-06 Ramin Norouzi , Amirreza Kosari , Mark H. Lowenberg

This paper aims to unify spatial dependency and temporal dependency in a non-Euclidean space while capturing the inner spatial-temporal dependencies for traffic data. For spatial-temporal attribute entities with topological structure, the…

Machine Learning · Computer Science 2022-06-28 Zonghan Wu , Da Zheng , Shirui Pan , Quan Gan , Guodong Long , George Karypis

Transition path theory computes statistics from ensembles of reactive trajectories. A common strategy for sampling reactive trajectories is to control the branching and pruning of trajectories so as to enhance the sampling of low…

Statistical Mechanics · Physics 2022-08-10 Bodhi P. Vani , Jonathan Weare , Aaron R. Dinner

This paper presents a novel framework for accurate pedestrian intent prediction at intersections. Given some prior knowledge of the curbside geometry, the presented framework can accurately predict pedestrian trajectories, even in new…

Machine Learning · Computer Science 2018-06-26 Nikita Jaipuria , Golnaz Habibi , Jonathan P. How

Diffusion Bridge and Flow Matching have both demonstrated compelling empirical performance in transformation between arbitrary distributions. However, there remains confusion about which approach is generally preferable, and the substantial…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Kaizhen Zhu , Mokai Pan , Zhechuan Yu , Jingya Wang , Jingyi Yu , Ye Shi

Reliable mathematical and scientific reasoning remains an open challenge for large vision-language models. Standard final-answer evaluation often masks reasoning errors, allowing silent failures to persist. To address this gap, we introduce…

Artificial Intelligence · Computer Science 2025-12-15 Shima Imani , Seungwhan Moon , Lambert Mathias , Lu Zhang , Babak Damavandi

We study the problem of inferring network topology from information cascades, in which the amount of time taken for information to diffuse across an edge in the network follows an unknown distribution. Unlike previous studies, which assume…

Social and Information Networks · Computer Science 2019-03-05 Feng Ji , Wenchang Tang , Wee Peng Tay , Edwin K. P. Chong

The estimation of causal network architectures in the brain is fundamental for understanding cognitive information processes. However, access to the dynamic processes underlying cognition is limited to indirect measurements of the hidden…

Neurons and Cognition · Quantitative Biology 2020-08-17 H. C. Ruiz-Euler , H. J. Kappen

Using the growing volumes of vehicle trajectory data, it becomes increasingly possible to capture time-varying and uncertain travel costs in a road network, including travel time and fuel consumption. The current paradigm represents a road…

Databases · Computer Science 2015-12-07 Jian Dai , Bin Yang , Chenjuan Guo , Christian S. Jensen

This paper presents Robust samplE-based coVarIance StEering (REVISE), a multi-query algorithm that generates robust belief roadmaps for dynamic systems navigating through spatially dependent disturbances modeled as a Gaussian random field.…

Robotics · Computer Science 2024-11-21 Alex Rose , Naman Aggarwal , Christopher Jewison , Jonathan P. How

Sparsification aims at extracting a reduced core of associations that best preserves both the dynamics and topology of networks while reducing the computational cost of simulations. We show that the semi-metric topology of complex networks…

Physics and Society · Physics 2025-06-05 David Soriano Paños , Felipe Xavier Costa , Luis M. Rocha

The lack of analytical models describing diffusion time dependence at intermediate time scales in complex tissue microstructure limits the accurate quantification of extracellular diffusivity and tissue microstructure. We introduce TRACED,…