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Due to the high complexity and technical requirements of industrial production processes, surface defects will inevitably appear, which seriously affects the quality of products. Although existing lightweight detection networks are highly…

Computer Vision and Pattern Recognition · Computer Science 2024-08-27 Xuyi Yu

Masked diffusion language models generate text through iterative masked-token filling, but terminal-only rewards on final completions provide coarse credit assignment for the intermediate filling decisions that shape the generation process.…

Computation and Language · Computer Science 2026-05-20 Daisuke Oba , Hiroki Furuta , Naoaki Okazaki

Without using explicit reward, direct preference optimization (DPO) employs paired human preference data to fine-tune generative models, a method that has garnered considerable attention in large language models (LLMs). However, exploration…

Computer Vision and Pattern Recognition · Computer Science 2025-03-25 Yunhong Lu , Qichao Wang , Hengyuan Cao , Xierui Wang , Xiaoyin Xu , Min Zhang

We aim to solve the problem of generating coarse-to-fine skills learning from demonstrations (LfD). To scale precision, traditional LfD approaches often rely on extensive fine-grained demonstrations with external interpolations or dynamics…

Robotics · Computer Science 2026-02-25 Nayoung Oh , Jaehyeong Jang , Moonkyeong Jung , Daehyung Park

Masked Diffusion Models (MDMs) offer flexible, non-autoregressive generation, but this freedom introduces a challenge: final output quality is highly sensitive to the decoding order. We are the first to formalize this issue, attributing the…

Computation and Language · Computer Science 2025-12-25 Ziyu Chen , Xinbei Jiang , Peng Sun , Tao Lin

Diffusion Policies have become widely used in Imitation Learning, offering several appealing properties, such as generating multimodal and discontinuous behavior. As models are becoming larger to capture more complex capabilities, their…

Machine Learning · Computer Science 2024-12-18 Moritz Reuss , Jyothish Pari , Pulkit Agrawal , Rudolf Lioutikov

Recent studies, including DeepSeek-R1 and Kimi-k1.5, have demonstrated that reinforcement learning with rule-based, binary-valued reward functions can significantly enhance the reasoning capabilities of large language models. These models…

Machine Learning · Computer Science 2025-06-04 Changyi Xiao , Mengdi Zhang , Yixin Cao

We propose Diffusion-Sharpening, a fine-tuning approach that enhances downstream alignment by optimizing sampling trajectories. Existing RL-based fine-tuning methods focus on single training timesteps and neglect trajectory-level alignment,…

Computer Vision and Pattern Recognition · Computer Science 2025-02-18 Ye Tian , Ling Yang , Xinchen Zhang , Yunhai Tong , Mengdi Wang , Bin Cui

Computational models that accurately predict the binding affinity of an input protein-chemical pair can accelerate drug discovery studies. These models are trained on available protein-chemical interaction datasets, which may contain…

Quantitative Methods · Quantitative Biology 2023-01-10 Rıza Özçelik , Alperen Bağ , Berk Atıl , Melih Barsbey , Arzucan Özgür , Elif Özkırımlı

Controllable diffusion generation often relies on various heuristics that are seemingly disconnected without a unified understanding. We bridge this gap with Diffusion Controller (DiffCon), a unified control-theoretic view that casts…

Machine Learning · Computer Science 2026-03-10 Tong Yang , Moonkyung Ryu , Chih-Wei Hsu , Guy Tennenholtz , Yuejie Chi , Craig Boutilier , Bo Dai

Drug discovery is a highly complicated process, and it is unfeasible to fully commit it to the recently developed molecular generation methods. Deep learning-based lead optimization takes expert knowledge as a starting point, learning from…

Discrete diffusion models have demonstrated great promise in modeling various sequence data, ranging from human language to biological sequences. Inspired by the success of RL in language models, there is growing interest in further…

Machine Learning · Computer Science 2026-02-03 Jiaqi Han , Austin Wang , Minkai Xu , Wenda Chu , Meihua Dang , Haotian Ye , Huayu Chen , Yisong Yue , Stefano Ermon

Recent studies have demonstrated the effectiveness of directly aligning diffusion models with human preferences using differentiable reward. However, they exhibit two primary challenges: (1) they rely on multistep denoising with gradient…

Artificial Intelligence · Computer Science 2025-09-12 Xiangwei Shen , Zhimin Li , Zhantao Yang , Shiyi Zhang , Yingfang Zhang , Donghao Li , Chunyu Wang , Qinglin Lu , Yansong Tang

Structure-based drug design (SBDD) aims to discover drug candidates by finding molecules (ligands) that bind tightly to a disease-related protein (targets), which is the primary approach to computer-aided drug discovery. Recently, applying…

Quantitative Methods · Quantitative Biology 2022-12-01 Tianfan Fu , Wenhao Gao , Connor W. Coley , Jimeng Sun

Parameter-Efficient FineTuning (PEFT) methods have recently gained significant popularity thanks to the widespread availability of large-scale pretrained models. These methods allow for quick adaptation to downstream tasks with minimal…

Machine Learning · Computer Science 2025-05-20 Massimo Bini , Leander Girrbach , Zeynep Akata

Recent advances align diffusion models with human preferences to increase aesthetic appeal and mitigate artifacts and biases. Such methods aim to maximize a conditional output distribution aligned with higher rewards whilst not drifting far…

Machine Learning · Computer Science 2026-02-23 Ratnavibusena Don Shahain Manujith , Teoh Tze Tzun , Kenji Kawaguchi , Yang Zhang

We present PANDORA, a novel diffusion-based policy learning framework designed specifically for dexterous robotic piano performance. Our approach employs a conditional U-Net architecture enhanced with FiLM-based global conditioning, which…

Machine Learning · Computer Science 2025-03-20 Yanjia Huang , Renjie Li , Zhengzhong Tu

Low-dose computed tomography (LDCT) lower potential risks linked to radiation exposure while relying on advanced denoising algorithms to maintain diagnostic quality in reconstructed images. The reigning paradigm in LDCT denoising is based…

Image and Video Processing · Electrical Eng. & Systems 2024-12-17 Şaban Öztürk , Oğuz Can Duran , Tolga Çukur

Diffusion policies have recently emerged as a powerful class of visuomotor controllers for robot manipulation, offering stable training and expressive multi-modal action modeling. However, existing approaches typically treat action…

Robotics · Computer Science 2025-10-01 Zezeng Li , Rui Yang , Ruochen Chen , ZhongXuan Luo , Liming Chen

Diffusion models have been recently employed to improve certified robustness through the process of denoising. However, the theoretical understanding of why diffusion models are able to improve the certified robustness is still lacking,…

Machine Learning · Computer Science 2022-11-02 Chaowei Xiao , Zhongzhu Chen , Kun Jin , Jiongxiao Wang , Weili Nie , Mingyan Liu , Anima Anandkumar , Bo Li , Dawn Song