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Graphs are ubiquitous data structures for representing interactions between entities. With an emphasis on the use of graphs to represent chemical molecules, we explore the task of learning to generate graphs that conform to a distribution…

Machine Learning · Computer Science 2019-03-08 Qi Liu , Miltiadis Allamanis , Marc Brockschmidt , Alexander L. Gaunt

Language modality within the vision language pretraining framework is innately discretized, endowing each word in the language vocabulary a semantic meaning. In contrast, visual modality is inherently continuous and high-dimensional, which…

Computer Vision and Pattern Recognition · Computer Science 2022-08-02 Xiaoyuan Guo , Jiali Duan , C. -C. Jay Kuo , Judy Wawira Gichoya , Imon Banerjee

Visual tokenizers are fundamental to image generation. They convert visual data into discrete tokens, enabling transformer-based models to excel at image generation. Despite their success, VQ-based tokenizers like VQGAN face significant…

Computer Vision and Pattern Recognition · Computer Science 2024-11-28 Zechen Bai , Jianxiong Gao , Ziteng Gao , Pichao Wang , Zheng Zhang , Tong He , Mike Zheng Shou

Most current molecular language models transfer the masked language model or image-text generation model from natural language processing to molecular field. However, molecules are not solely characterized by atom/bond symbols; they…

Emerging Technologies · Computer Science 2024-11-26 Yifan Wu , Min Zeng , Yang Li , Yang Zhang , Min Li

We apply a number of atomic decomposition schemes across the standard QM7 dataset -- a small model set of organic molecules at equilibrium geometry -- to inspect the possible emergence of trends among contributions to atomization energies…

Chemical Physics · Physics 2023-04-19 Frederik Ø. Kjeldal , Janus J. Eriksen

In drug-discovery-related tasks such as virtual screening, machine learning is emerging as a promising way to predict molecular properties. Conventionally, molecular fingerprints (numerical representations of molecules) are calculated…

Machine Learning · Computer Science 2019-11-13 Shion Honda , Shoi Shi , Hiroki R. Ueda

Deep learning has brought significant improvements to the field of cross-modal representation learning. For tasks such as text-to-speech (TTS), voice conversion (VC), and automatic speech recognition (ASR), a cross-modal fine-grained…

Audio and Speech Processing · Electrical Eng. & Systems 2025-05-29 Chunyu Qiang , Wang Geng , Yi Zhao , Ruibo Fu , Tao Wang , Cheng Gong , Tianrui Wang , Qiuyu Liu , Jiangyan Yi , Zhengqi Wen , Chen Zhang , Hao Che , Longbiao Wang , Jianwu Dang , Jianhua Tao

The growing demand for Large Language Models (LLMs) in applications such as content generation, intelligent chatbots, and sentiment analysis poses considerable challenges for LLM service providers. To efficiently use GPU resources and boost…

Machine Learning · Computer Science 2024-04-17 Yilong Zhao , Chien-Yu Lin , Kan Zhu , Zihao Ye , Lequn Chen , Size Zheng , Luis Ceze , Arvind Krishnamurthy , Tianqi Chen , Baris Kasikci

Representation learning and \emph{de novo} generation of proteins are pivotal computational biology tasks. Whilst natural language processing (NLP) techniques have proven highly effective for protein sequence modelling, structure modelling…

Quantitative Methods · Quantitative Biology 2025-01-08 Benoit Gaujac , Jérémie Donà , Liviu Copoiu , Timothy Atkinson , Thomas Pierrot , Thomas D. Barrett

Atomic level qubits in silicon are attractive candidates for large-scale quantum computing, however, their quantum properties and controllability are sensitive to details such as the number of donor atoms comprising a qubit and their…

Mesoscale and Nanoscale Physics · Physics 2020-03-17 Muhammad Usman , Yi Z. Wong , Charles D. Hill , Lloyd C. L. Hollenberg

Token-based video representation has emerged as a promising approach for enabling large language models (LLMs) to interpret video content. However, existing token reduction techniques, such as pruning and merging, often disrupt essential…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Haichao Zhang , Yun Fu

Deep learning-based semantic communication has largely relied on analog or semi-digital transmission, which limits compatibility with modern digital communication infrastructures. Recent studies have employed vector quantization (VQ) to…

Signal Processing · Electrical Eng. & Systems 2025-10-22 Zian Meng , Qiang Li , Wenqian Tang , Mingdie Yan , Xiaohu Ge

Molecular representation is a critical element in our understanding of the physical world and the foundation for modern molecular machine learning. Previous molecular machine learning models have employed strings, fingerprints, global…

Machine Learning · Computer Science 2025-05-28 Daniil A. Boiko , Thiago Reschützegger , Benjamin Sanchez-Lengeling , Samuel M. Blau , Gabe Gomes

Atomic properties such as partial charges or multipoles encode chemically meaningful information that can inform downstream molecular property prediction, but their evaluation as machine learning targets has been complicated by the absence…

Large-scale pre-trained Vision-Language Models (VLMs) have gained prominence in various visual and multimodal tasks, yet the deployment of VLMs on downstream application platforms remains challenging due to their prohibitive requirements of…

Computer Vision and Pattern Recognition · Computer Science 2024-09-27 Huixin Sun , Runqi Wang , Yanjing Li , Xianbin Cao , Xiaolong Jiang , Yao Hu , Baochang Zhang

Chemical representation learning has gained increasing interest due to the limited availability of supervised data in fields such as drug and materials design. This interest particularly extends to chemical language representation learning,…

Chemical Physics · Physics 2024-08-06 Jun-Hyung Park , Yeachan Kim , Mingyu Lee , Hyuntae Park , SangKeun Lee

Unsupervised learning of discrete representations in neural networks (NNs) from continuous ones is essential for many modern applications. Vector Quantisation (VQ) has become popular for this, in particular in the context of generative…

Machine Learning · Computer Science 2024-07-10 Kazuki Irie , Róbert Csordás , Jürgen Schmidhuber

Molecules are graphs, but large language models~(LLMs) are usually asked to reason about them through linear strings. The most popular molecular representation, SMILES, compresses atoms, bonds, branches and rings into a compact sequence in…

Biomolecules · Quantitative Biology 2026-05-19 Zhiyuan Yan , Chen Liu , Boxuan Zhao , Kaiqing Lin , Jixiang Zhao , Yimi Wang , Liuzhenghao Lv , Hao Li , Shanzhuo Zhang , Li Yuan , Fanyang Mo

The visual understanding are often approached from 3 granular levels: image, patch and pixel. Visual Tokenization, trained by self-supervised reconstructive learning, compresses visual data by codebook in patch-level with marginal…

Computer Vision and Pattern Recognition · Computer Science 2024-12-19 Jianyu Zhang , Li Zhang , Shijian Li

The distributed and continuous representations used by neural networks are at odds with representations employed in linguistics, which are typically symbolic. Vector quantization has been proposed as a way to induce discrete neural…

Computation and Language · Computer Science 2021-09-17 Bertrand Higy , Lieke Gelderloos , Afra Alishahi , Grzegorz Chrupała