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We present Apertus, a fully open suite of large language models (LLMs) designed to address two systemic shortcomings in today's open model ecosystem: data compliance and multilingual representation. Unlike many prior models that release…

Computation and Language · Computer Science 2025-12-03 Project Apertus , Alejandro Hernández-Cano , Alexander Hägele , Allen Hao Huang , Angelika Romanou , Antoni-Joan Solergibert , Barna Pasztor , Bettina Messmer , Dhia Garbaya , Eduard Frank Ďurech , Ido Hakimi , Juan García Giraldo , Mete Ismayilzada , Negar Foroutan , Skander Moalla , Tiancheng Chen , Vinko Sabolčec , Yixuan Xu , Michael Aerni , Badr AlKhamissi , Inés Altemir Mariñas , Mohammad Hossein Amani , Matin Ansaripour , Ilia Badanin , Harold Benoit , Emanuela Boros , Nicholas Browning , Fabian Bösch , Maximilian Böther , Niklas Canova , Camille Challier , Clement Charmillot , Jonathan Coles , Jan Deriu , Arnout Devos , Lukas Drescher , Daniil Dzenhaliou , Maud Ehrmann , Dongyang Fan , Simin Fan , Silin Gao , Miguel Gila , María Grandury , Diba Hashemi , Alexander Hoyle , Jiaming Jiang , Mark Klein , Andrei Kucharavy , Anastasiia Kucherenko , Frederike Lübeck , Roman Machacek , Theofilos Manitaras , Andreas Marfurt , Kyle Matoba , Simon Matrenok , Henrique Mendonça , Fawzi Roberto Mohamed , Syrielle Montariol , Luca Mouchel , Sven Najem-Meyer , Jingwei Ni , Gennaro Oliva , Matteo Pagliardini , Elia Palme , Andrei Panferov , Léo Paoletti , Marco Passerini , Ivan Pavlov , Auguste Poiroux , Kaustubh Ponkshe , Nathan Ranchin , Javi Rando , Mathieu Sauser , Jakhongir Saydaliev , Muhammad Ali Sayfiddinov , Marian Schneider , Stefano Schuppli , Marco Scialanga , Andrei Semenov , Kumar Shridhar , Raghav Singhal , Anna Sotnikova , Alexander Sternfeld , Ayush Kumar Tarun , Paul Teiletche , Jannis Vamvas , Xiaozhe Yao , Hao Zhao , Alexander Ilic , Ana Klimovic , Andreas Krause , Caglar Gulcehre , David Rosenthal , Elliott Ash , Florian Tramèr , Joost VandeVondele , Livio Veraldi , Martin Rajman , Thomas Schulthess , Torsten Hoefler , Antoine Bosselut , Martin Jaggi , Imanol Schlag

Background Large Language Models (LLMs), enhanced with Clinical Practice Guidelines (CPGs), can significantly improve Clinical Decision Support (CDS). However, methods for incorporating CPGs into LLMs are not well studied. Methods We…

Computation and Language · Computer Science 2024-01-25 David Oniani , Xizhi Wu , Shyam Visweswaran , Sumit Kapoor , Shravan Kooragayalu , Katelyn Polanska , Yanshan Wang

Biomedical multimodal assistants have the potential to unify radiology, pathology, and clinical-text reasoning, yet a critical deployment gap remains: top-performing systems are either closed-source or computationally prohibitive,…

Computation and Language · Computer Science 2026-03-03 Kai Zhang , Zhengqing Yuan , Cheng Peng , Songlin Zhao , Mengxian Lyu , Ziyi Chen , Yanfang Ye , Wei Liu , Ying Zhang , Kaleb E Smith , Lifang He , Lichao Sun , Yonghui Wu

Medical image segmentation is vital for clinical diagnosis, yet current deep learning methods often demand extensive expert effort, i.e., either through annotating large training datasets or providing prompts at inference time for each new…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Xingjian Li , Qifeng Wu , Adithya S. Ubaradka , Yiran Ding , Colleen Que , Runmin Jiang , Jianhua Xing , Tianyang Wang , Min Xu

Application of deep learning on histopathological whole slide images (WSIs) holds promise of improving diagnostic efficiency and reproducibility but is largely dependent on the ability to write computer code or purchase commercial…

Machine learning (ML)-based cyber-physical systems (CPSs) have been extensively developed to improve the print quality of additive manufacturing (AM). However, the reproducibility of these systems, as presented in published research, has…

Computational Engineering, Finance, and Science · Computer Science 2024-10-23 Jiarui Xie , Mutahar Safdar , Andrei Mircea , Bi Cheng Zhao , Yan Lu , Hyunwoong Ko , Zhuo Yang , Yaoyao Fiona Zhao

Privacy-preserving medical decision support for kidney disease requires localized deployment of large language models (LLMs) while maintaining clinical reasoning capabilities. Current solutions face three challenges: 1) Cloud-based LLMs…

Artificial Intelligence · Computer Science 2025-03-07 Yongchao Long , Chao Yang , Gongzheng Tang , Jinwei Wang , Zhun Sui , Yuxi Zhou , Shenda Hong , Luxia Zhang

The rapid escalation in the parameter count of large language models (LLMs) has transformed model training from a single-node endeavor into a highly intricate, cross-node activity. While frameworks such as Megatron-LM successfully integrate…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-07-29 Bohan Zhao , Guang Yang , Shuo Chen , Ruitao Liu , Tingrui Zhang , Yongchao He , Wei Xu

Medical vision--language models (MVLMs) are increasingly used as perceptual backbones in radiology pipelines and as the visual front end of multimodal assistants, yet their reliability under real clinical workflows remains underexplored.…

Computer Vision and Pattern Recognition · Computer Science 2026-04-06 Xiang Chen , Fangfang Yang , Chunlei Meng , Yuxian Dong , Ang Li , Yiwei Wei , Jiahuan Long , Jiujiang Guo , Chengyin Hu

Clinical decision-making requires synthesizing heterogeneous evidence, including patient histories, clinical guidelines, and trajectories of comparable cases. While large language models (LLMs) offer strong reasoning capabilities, they…

Artificial Intelligence · Computer Science 2026-03-03 Shuheng Chen , Namratha Patil , Haonan Pan , Angel Hsing-Chi Hwang , Yao Du , Ruishan Liu , Jieyu Zhao

As medical large language models (LLMs) become increasingly integrated into clinical workflows, concerns around alignment robustness, and safety are escalating. Prior work on model extraction has focused on classification models or…

Machine Learning · Computer Science 2025-12-11 Sohely Jahan , Ruimin Sun

Remarkable progress has been made in automated problem solving through societies of agents based on large language models (LLMs). Computational fluid dynamics (CFD), as a complex problem, presents unique challenges in automated simulations…

Artificial Intelligence · Computer Science 2024-08-08 Yuxuan Chen , Xu Zhu , Hua Zhou , Zhuyin Ren

Large language models (LLMs) excel on many NLP benchmarks, but their behavior on real-world, semi-structured prediction remains underexplored. We present LlaMADRS, a benchmark for structured clinical assessment from dialogue built on the…

Human-Computer Interaction · Computer Science 2026-04-23 Gaoussou Youssouf Kebe , Jeffrey M. Girard , Einat Liebenthal , Justin Baker , Fernando De la Torre , Louis-Philippe Morency

Clinical guidelines, typically structured as decision trees, are central to evidence-based medical practice and critical for ensuring safe and accurate diagnostic decision-making. However, it remains unclear whether Large Language Models…

Computation and Language · Computer Science 2025-05-20 Xiaomin Li , Mingye Gao , Yuexing Hao , Taoran Li , Guangya Wan , Zihan Wang , Yijun Wang

Accurate delineation of anatomical structures in volumetric CT scans is crucial for diagnosis and treatment planning. While AI has advanced automated segmentation, current approaches typically target individual structures, creating a…

The proliferation of SQL for data processing has often occurred without the rigor of traditional software development, leading to siloed efforts, logic replication, and increased risk. This ad-hoc approach hampers data governance and makes…

Systems and Control · Electrical Eng. & Systems 2025-11-18 Dmytro Valiaiev

The rapid advancement of large language models presents significant opportunities for financial applications, yet systematic evaluation in specialized financial contexts remains limited. This study presents the first comprehensive…

Computation and Language · Computer Science 2025-09-08 Xuan Yao , Qianteng Wang , Xinbo Liu , Ke-Wei Huang

Augmenting Large Language Models (LLMs) with external tools enables them to execute complex, multi-step tasks. However, tool learning is hampered by the static synthetic data pipelines where data generation and model training are executed…

Computation and Language · Computer Science 2025-11-19 Kangning Zhang , Wenxiang Jiao , Kounianhua Du , Yuan Lu , Weiwen Liu , Weinan Zhang , Yong Yu

The deployment of Large Language Models (LLMs) for structuring clinical data is critically hindered by their tendency to hallucinate facts and their inability to follow domain-specific rules. To address this, we introduce MedPAO, a novel…

Reconstructing the intrinsic Ly$\alpha$ line flux from high-$z$ QSOs can place constraints on the neutral hydrogen content of the intergalactic medium during reionisation. There are now $\gtrsim10$ different Ly$\alpha$ reconstruction…