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Doctors and patients alike increasingly use Large Language Models (LLMs) to diagnose clinical cases. However, unlike domains such as math or coding, where correctness can be objectively defined by the final answer, medical diagnosis…

Computation and Language · Computer Science 2025-05-21 Kevin Wu , Eric Wu , Rahul Thapa , Kevin Wei , Angela Zhang , Arvind Suresh , Jacqueline J. Tao , Min Woo Sun , Alejandro Lozano , James Zou

Longitudinal information in radiology reports refers to the sequential tracking of findings across multiple examinations over time, which is crucial for monitoring disease progression and guiding clinical decisions. Many recent automated…

Computation and Language · Computer Science 2026-01-26 Xinyi Wang , Grazziela Figueredo , Ruizhe Li , Xin Chen

Recently, Large Language Models (LLMs) have undergone a significant transformation, marked by a rapid rise in both their popularity and capabilities. Leading this evolution are proprietary LLMs like GPT-4 and GPT-o1, which have captured…

Clinical Decision Support Systems (CDSS) utilize evidence-based knowledge and patient data to offer real-time recommendations, with Large Language Models (LLMs) emerging as a promising tool to generate plain-text explanations for medical…

Computation and Language · Computer Science 2023-10-04 D. Umerenkov , G. Zubkova , A. Nesterov

We present Clinical Camel, an open large language model (LLM) explicitly tailored for clinical research. Fine-tuned from LLaMA-2 using QLoRA, Clinical Camel achieves state-of-the-art performance across medical benchmarks among openly…

Computation and Language · Computer Science 2023-08-21 Augustin Toma , Patrick R. Lawler , Jimmy Ba , Rahul G. Krishnan , Barry B. Rubin , Bo Wang

Medical vision--language models (VLMs) are usually evaluated on intact image--question pairs, but trustworthy clinical use requires a stronger property: a model must recognise when the evidential basis for an answer has failed. We study…

Computer Vision and Pattern Recognition · Computer Science 2026-05-25 Hanqi Jiang , Junhao Chen , Mingyu Kang , Hyeokjae Kwon , Yi Pan , Lifeng Chen , Weihang You , Haozhen Gong , Ruiyu Yan , Jinglei Lv , Lin Zhao , Hui Ren , Quanzheng Li , Tianming Liu , Xiang Li

Merging natural language interfaces with computational fluid dynamics (CFD) workflows presents transformative opportunities for both industry and research. In this study, we introduce OptMetaOpenFOAM - a novel framework that bridges…

Artificial Intelligence · Computer Science 2025-03-04 Yuxuan Chen , Long Zhang , Xu Zhu , Hua Zhou , Zhuyin Ren

Medical question-answering (QA) is a critical task for evaluating how effectively large language models (LLMs) encode clinical knowledge and assessing their potential applications in medicine. Despite showing promise on multiple-choice…

Computation and Language · Computer Science 2025-03-06 Guangfu Guo , Kai Zhang , Bryan Hoo , Yujun Cai , Xiaoqian Lu , Nanyun Peng , Yiwei Wang

Extracting sections from clinical notes is crucial for downstream analysis but is challenging due to variability in formatting and labor-intensive nature of manual sectioning. While proprietary large language models (LLMs) have shown…

Computation and Language · Computer Science 2025-01-27 Joshua Davis , Thomas Sounack , Kate Sciacca , Jessie M Brain , Brigitte N Durieux , Nicole D Agaronnik , Charlotta Lindvall

The learning process for medical residents presents significant challenges, demanding both the ability to interpret complex case reports and the rapid acquisition of accurate medical knowledge from reliable sources. Residents typically…

Computation and Language · Computer Science 2026-02-03 Dongsuk Jang , Ziyao Shangguan , Kyle Tegtmeyer , Anurag Gupta , Jan Czerminski , Sophie Chheang , Arman Cohan

Clinical Decision Support Systems (CDSSs) provide reasoning and inquiry guidance for physicians, yet they face notable challenges, including high maintenance costs and low generalization capability. Recently, Large Language Models (LLMs)…

Computation and Language · Computer Science 2026-04-24 Yue Guo , Fanfu Wang , Jianwei Lv , Xincheng Shi , Yuchen Li , Youya Wang , Yunsheng Zeng , Yujing Liu , Yunhao Qiao , Gen Li , Junfeng Wang , Bo Yuan

There have been numerous attempts to distill quadratic attention-based large language models (LLMs) into sub-quadratic linearized architectures. However, despite extensive research, such distilled models often fail to match the performance…

Recently, Large Language Models (LLMs) have gained significant traction in medical domain, especially in developing a QA systems to Medical QA systems for enhancing access to healthcare in low-resourced settings. This paper compares five…

Computation and Language · Computer Science 2026-02-17 Shefayat E Shams Adib , Ahmed Alfey Sani , Ekramul Alam Esham , Ajwad Abrar , Tareque Mohmud Chowdhury

Large language models are often adapted through parameter efficient fine tuning, but current release practices provide weak assurances about what data were used and how updates were computed. We present Verifiable Fine Tuning, a protocol…

Cryptography and Security · Computer Science 2025-12-30 Hasan Akgul , Daniel Borg , Arta Berisha , Amina Rahimova , Andrej Novak , Mila Petrov

In 2008, melamine in infant formula forced laboratories across three continents to verify a compound they had never monitored. Non-targeted analysis using LC/GC-HRMS handles these cases. But when findings trigger regulatory action,…

Computational Engineering, Finance, and Science · Computer Science 2025-12-24 Sarah Alsubaie , Sakhaa Alsaedi , Xin Gao

Recently, large models have shown significant potential for smart healthcare. However, the deployment of Large Vision-Language Models (LVLMs) for clinical services is currently hindered by three critical challenges: a tendency to…

Artificial Intelligence · Computer Science 2025-10-27 Siyong Chen , Jinbo Wen , Jiawen Kang , Tenghui Huang , Xumin Huang , Yuanjia Su , Hudan Pan , Zishao Zhong , Dusit Niyato , Shengli Xie , Dong In Kim

Schema-guided reasoning pipelines ask LLMs to produce explicit intermediate structures -- rubrics, checklists, verification queries -- before committing to a final decision. But do these structures causally determine the output, or merely…

Artificial Intelligence · Computer Science 2026-03-18 Oleg Somov , Mikhail Chaichuk , Mikhail Seleznyov , Alexander Panchenko , Elena Tutubalina

The reproducibility of computational pipelines is an expectation in biomedical science, particularly in critical domains like human health. In this context, reporting next generation genome sequencing methods used in precision medicine…

Computational Engineering, Finance, and Science · Computer Science 2024-12-11 Meznah Aloqalaa , Stian Soiland-Reyes , Carole Goble

This research focuses on evaluating the non-commercial open-source large language models (LLMs) Meditron, MedAlpaca, Mistral, and Llama-2 for their efficacy in interpreting medical guidelines saved in PDF format. As a specific test…

Computation and Language · Computer Science 2025-02-14 Mohamed Yaseen Jabarulla , Steffen Oeltze-Jafra , Philipp Beerbaum , Theodor Uden

The development of Large Speech-Language Models (LSLMs) has been slowed by fragmented architectures and a lack of transparency, hindering the systematic comparison and reproducibility of research. Unlike in the vision-language domain, the…

Computation and Language · Computer Science 2025-08-22 Yirong Sun , Yizhong Geng , Peidong Wei , Yanjun Chen , Jinghan Yang , Rongfei Chen , Wei Zhang , Xiaoyu Shen