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This article introduces a conjecture that formalises a fundamental trade-off between provable correctness and broad data-mapping capacity in Artificial Intelligence (AI) systems. When an AI system is engineered for deductively watertight…

Artificial Intelligence · Computer Science 2025-08-05 Luciano Floridi

The performance of AI models on safety benchmarks does not indicate their real-world performance after deployment. This opaqueness of AI models impedes existing regulatory frameworks constituted on benchmark performance, leaving them…

Machine Learning · Computer Science 2025-12-16 Gabriel Stanovsky , Renana Keydar , Gadi Perl , Eliya Habba

Model checking of strategic abilities is a notoriously hard problem, even more so in the realistic case of agents with imperfect information, acting in a stochastic environment. Assume-guarantee reasoning can be of great help here,…

Multiagent Systems · Computer Science 2025-11-17 Wojciech Jamroga , Damian Kurpiewski , Łukasz Mikulski

Combining a spatiotemporal, multi-agent based model of a foraging ecosystem with linear, genetically programmed rules for the agents' behaviors results in implicit, endogenous, objective functions and selection algorithms based on "natural…

Neural and Evolutionary Computing · Computer Science 2023-06-01 John C Stevenson

Different types of reasoning impose different structural demands on representational systems, yet no systematic account of these demands exists across psychology, AI, and philosophy of mind. I propose a framework identifying four structural…

Artificial Intelligence · Computer Science 2026-04-03 Yiling Wu

Genetic regulatory networks are defined by their topology and by a multitude of continuously adjustable parameters. Here we present a class of simple models within which the relative importance of topology vs. interaction strengths becomes…

Molecular Networks · Quantitative Biology 2013-08-02 Mikhail Tikhonov , William Bialek

The proliferation of autonomous AI agents marks a paradigm shift toward complex, emergent multi-agent systems. This transition introduces systemic security risks, including control-flow hijacking and cascading failures, that traditional…

Cryptography and Security · Computer Science 2025-08-28 Sai Teja Reddy Adapala , Yashwanth Reddy Alugubelly

The benchmarks used to evaluate AI agents in security-critical roles suffer from crucial weaknesses. Building on recent empirical evidence, we characterize three core challenges that undermine security evaluations: benchmark…

Cryptography and Security · Computer Science 2026-05-22 Sahar Abdelnabi , Chris Hicks , Konrad Rieck , Ahmad-Reza Sadeghi

Data lakehouses run sensitive workloads, where AI-driven automation raises concerns about trust, correctness, and governance. We argue that API-first, programmable lakehouses provide the right abstractions for safe-by-design, agentic…

Artificial Intelligence · Computer Science 2025-10-13 Jacopo Tagliabue , Ciro Greco

Systems biology models are useful models of complex biological systems that may require a large amount of experimental data to fit each model's parameters or to approximate a likelihood function. These models range from a few to thousands…

Quantitative Methods · Quantitative Biology 2024-07-12 Vincent D. Zaballa , Elliot E. Hui

The rise of biomedical foundation models creates new hurdles in model testing and authorization, given their broad capabilities and susceptibility to complex distribution shifts. We suggest tailoring robustness tests according to…

Software Engineering · Computer Science 2025-09-01 R. Patrick Xian , Noah R. Baker , Tom David , Qiming Cui , A. Jay Holmgren , Stefan Bauer , Madhumita Sushil , Reza Abbasi-Asl

Securing Agentic Artificial Intelligence (AI) systems requires addressing the complex cyber risks introduced by autonomous, decision-making, and adaptive behaviors. Agentic AI systems are increasingly deployed across industries,…

Cryptography and Security · Computer Science 2025-12-23 Sunil Arora , John Hastings

Classical scaling laws model AI performance as monotonically improving with model size. We challenge this assumption by deriving the Institutional Scaling Law, showing that institutional fitness -- jointly measuring capability, trust,…

Artificial Intelligence · Computer Science 2026-03-17 Mark Baciak , Thomas A. Cellucci

Tool-integrated agents are deployed on the premise that external tools ground their outputs in reality. Yet this very reliance creates a critical attack surface. Current evaluations benchmark capability in benign settings, asking "can the…

Artificial Intelligence · Computer Science 2026-04-22 Zhonghao Zhan , Huichi Zhou , Zhenhao Li , Peiyuan Jing , Krinos Li , Hamed Haddadi

AI agents, predominantly powered by large language models (LLMs), are vulnerable to indirect prompt injection, in which malicious instructions embedded in untrusted data can trigger dangerous agent actions. This position paper discusses our…

Cryptography and Security · Computer Science 2026-04-01 Chong Xiang , Drew Zagieboylo , Shaona Ghosh , Sanjay Kariyappa , Kai Greshake , Hanshen Xiao , Chaowei Xiao , G. Edward Suh

AI models underpin data-centric applications from image and text processing to scientific discovery in biology, physics, and chemistry. Yet developing them remains heavily manual, requiring practitioners to design architectures, build…

Artificial Intelligence · Computer Science 2026-05-28 Ruiyi Zhang , Peijia Qin , Qi Cao , Li Zhang , Pengtao Xie

AI models are increasingly deployed in live clinical environments where they must perform reliably across complex, high-stakes workflows that standard training and validation datasets were never designed to capture. Evaluating these systems…

Artificial Intelligence · Computer Science 2026-05-12 Prasanna Desikan , Harshit Rajgarhia , Shivali Dalmia , Ananya Mantravadi

Despite the obvious advantage of simple life forms capable of fast replication, different levels of cognitive complexity have been achieved by living systems in terms of their potential to cope with environmental uncertainty. Against the…

Populations and Evolution · Quantitative Biology 2017-10-18 Luís F Seoane , Ricard Solé

Embodied AI systems, comprising AI models and physical plants, are increasingly prevalent across various applications. Due to the rarity of system failures, ensuring their safety in complex operating environments remains a major challenge,…

Although artificial intelligence (AI) agents are increasingly proposed to support potentially longitudinal health tasks, such as symptom management, behavior change, and patient support, most current implementations fall short of…

Artificial Intelligence · Computer Science 2026-04-30 Georgianna Lin , Rencong Jiang , Noémie Elhadad , Xuhai "Orson" Xu