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Alignment research focuses on making individual AI systems reliable. Human institutions achieve reliable collective behaviour differently: they mitigate the risk posed by misaligned individuals through organisational structure. Multi-agent…
As artificial intelligence (AI) becomes increasingly embedded in the core functions of social, political, and economic life, it catalyzes structural transformations with far-reaching societal implications. This paper advances the concept of…
AI agents are now running real transactions, workflows, and sub-agent chains across organizational boundaries without continuous human supervision. This creates a problem no current infrastructure is equipped to solve: how do you identify,…
Institutional decisions -- regulatory compliance, clinical triage, prior authorization appeal -- require a different AI architecture than general-purpose agents provide. Agent frameworks infer authority conversationally, reconstruct…
Could artificial intelligence ever become truly conscious in a functional sense; this paper explores that open-ended question through the lens of Life, a concept unifying classical biological criteria (Oxford, NASA, Koshland) with empirical…
With artificial intelligence (AI) being applied to bring autonomy to decision-making in safety-critical domains such as the ones typified in the aerospace and emergency-response services, there has been a call to address the ethical…
As AI systems gain increasing autonomy and execution capability, the number of discovered security vulnerabilities continues to rise. However, many of these vulnerabilities are not fundamentally novel, but instead reflect recurring classes…
When automated decision systems fail, organizations frequently discover that formally compliant governance infrastructure cannot reconstruct what happened or why. This paper synthesizes an operational governance evidence framework --…
The last few years have witnessed substantial progress in the field of embodied AI where artificial agents, mirroring biological counterparts, are now able to learn from interaction to accomplish complex tasks. Despite this success,…
For over half a century, computer-aided structural elucidation systems (CASE) for organic compounds have relied on complex expert systems with explicitly programmed algorithms. These systems are often computationally inefficient for complex…
Recurrent neural networks are frequently studied in terms of their information-processing capabilities. The structural properties of these networks are seldom considered, beyond those emerging from the connectivity tuning necessary for…
Generative AI agents in life sciences face a critical challenge: determining the optimal approach for diverse queries ranging from simple factoid questions to complex mechanistic reasoning. Traditional methods rely on fixed rules or…
Artificial neural networks are being proposed as models of parts of the brain. The networks are compared to recordings of biological neurons, and good performance in reproducing neural responses is considered to support the model's…
Despite substantial efforts, deep learning has not yet delivered a transformative impact on elucidating regulatory biology, particularly in the realm of predicting gene expression profiles. Here, we argue that genuine "foundation models" of…
Across healthcare, agentic artificial intelligence (AI) systems are increasingly promoted as capable of autonomous action, yet in practice they currently operate under near-total human oversight due to safety, regulatory, and liability…
Artificial intelligence pipelines -- spanning data collection, model training, deployment, and post-deployment monitoring -- concentrate ethical risks that intensify with multimodal and agentic systems. Existing governance instruments,…
Current deep learning approaches for physiological signal monitoring suffer from static topologies and constant energy consumption. We introduce SGEMAS (Self-Growing Ephemeral Multi-Agent System), a bio-inspired architecture that treats…
Agentic artificial intelligence systems are autonomous technologies capable of pursuing complex goals with minimal human oversight and are rapidly emerging as the next frontier in AI. While these systems promise major gains in productivity,…
The pursuit of creating artificial intelligence (AI) mirrors our longstanding fascination with understanding our own intelligence. From the myths of Talos to Aristotelian logic and Heron's inventions, we have sought to replicate the marvels…
We outline the principles of classical assurance for computer-based systems that pose significant risks. We then consider application of these principles to systems that employ Artificial Intelligence (AI) and Machine Learning (ML). A key…