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Multimodal representation learning techniques typically rely on paired samples to learn common representations, but paired samples are challenging to collect in fields such as biology where measurement devices often destroy the samples.…

Machine Learning · Computer Science 2024-10-30 Johnny Xi , Jana Osea , Zuheng Xu , Jason Hartford

Multimodal federated learning (MFL) has emerged as a decentralized machine learning paradigm, allowing multiple clients with different modalities to collaborate on training a global model across diverse data sources without sharing their…

Machine Learning · Computer Science 2025-03-07 Huy Q. Le , Chu Myaet Thwal , Yu Qiao , Ye Lin Tun , Minh N. H. Nguyen , Eui-Nam Huh , Choong Seon Hong

With the increasing number of patients diagnosed with Alzheimer's Disease, prognosis models have the potential to aid in early disease detection. However, current approaches raise dependability concerns as they do not account for…

Neurons and Cognition · Quantitative Biology 2024-08-28 Wael Mobeirek , Shirley Mao

Accurate survival prediction from multimodal medical data is essential for precision oncology, yet clinical deployment faces a persistent challenge: modalities are frequently incomplete due to cost constraints, technical limitations, or…

Computer Vision and Pattern Recognition · Computer Science 2026-03-30 Kyungwon Kim , Dosik Hwang

The accurate diagnosis of Alzheimer's disease (AD) and prognosis of mild cognitive impairment (MCI) conversion are crucial for early intervention. However, existing multimodal methods face several challenges, from the heterogeneity of input…

Machine Learning · Computer Science 2025-03-20 Chenyu Liu , Luca Rossi

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that severely impairs cognitive function and quality of life. Timely intervention in AD relies heavily on early and precise diagnosis, which remains challenging due to the…

Computer Vision and Pattern Recognition · Computer Science 2025-08-11 Xiaoxiao Yang , Meiliang Liu , Yunfang Xu , Zijin Li , Zhengye Si , Xinyue Yang , Zhiwen Zhao

Multimodal large language models (MLLMs) have achieved remarkable success across various tasks. However, separate training of visual and textual encoders often results in a misalignment of the modality. Such misalignment may lead models to…

Computer Vision and Pattern Recognition · Computer Science 2025-06-09 Songtao Jiang , Yan Zhang , Ruizhe Chen , Tianxiang Hu , Yeying Jin , Qinglin He , Yang Feng , Jian Wu , Zuozhu Liu

Health conditions among patients in intensive care units (ICUs) are monitored via electronic health records (EHRs), composed of numerical time series and lengthy clinical note sequences, both taken at irregular time intervals. Dealing with…

Machine Learning · Computer Science 2023-06-07 Xinlu Zhang , Shiyang Li , Zhiyu Chen , Xifeng Yan , Linda Petzold

Alzheimer's disease (AD) is a progressive neurodegenerative condition necessitating early and precise diagnosis to provide prompt clinical management. Given the paramount importance of early diagnosis, recent studies have increasingly…

Machine Learning · Computer Science 2026-02-18 Fatemeh Khalvandi , Saadat Izadi , Abdolah Chalechale

Depression is a mental disorder and can cause a variety of symptoms, including psychological, physical, and social. Speech has been proved an objective marker for the early recognition of depression. For this reason, many studies have been…

Machine Learning · Computer Science 2026-05-12 Loukas Ilias , Dimitris Askounis

Learning from multiple modalities often suffers from imbalance, where information-rich modalities dominate optimization while weaker or partially missing modalities contribute less. This imbalance becomes severe in realistic settings with…

Computer Vision and Pattern Recognition · Computer Science 2026-03-23 Phuong-Anh Nguyen , Tien Anh Pham , Duc-Trong Le , Cam-Van Thi Nguyen

Using multiple spatial modalities has been proven helpful in improving semantic segmentation performance. However, there are several real-world challenges that have yet to be addressed: (a) improving label efficiency and (b) enhancing…

Computer Vision and Pattern Recognition · Computer Science 2023-04-24 Harsh Maheshwari , Yen-Cheng Liu , Zsolt Kira

Multimodal learning integrates diverse modalities but suffers from modality imbalance, where dominant modalities suppress weaker ones due to inconsistent convergence rates. Existing methods predominantly rely on static modulation or…

Machine Learning · Computer Science 2026-02-11 Zhaocheng Liu , Zhiwen Yu , Xiaoqing Liu

Predicting individual cognitive decline in Alzheimer's disease (AD) is difficult due to the heterogeneity of disease progression. Reliable clinical tools require not only high accuracy but also fairness across demographics and robustness to…

Artificial Intelligence · Computer Science 2026-04-27 Bulent Soykan , Gulsah Hancerliogullari Koksalmis , Hsin-Hsiung Huang , Laura J. Brattain

Recent studies suggest that combined analysis of Magnetic resonance imaging~(MRI) that measures brain atrophy and positron emission tomography~(PET) that quantifies hypo-metabolism provides improved accuracy in diagnosing Alzheimer's…

Computer Vision and Pattern Recognition · Computer Science 2018-07-31 Apoorva Sikka , Skand Vishwanath Peri , Deepti. R. Bathula

From clinical healthcare to daily living, continuous sensor monitoring across multiple modalities has shown great promise for real-world intelligent decision-making but also faces various challenges. In this work, we introduce MAESTRO, a…

Machine Learning · Computer Science 2025-10-01 Payal Mohapatra , Yueyuan Sui , Akash Pandey , Stephen Xia , Qi Zhu

Electronic Health Record (EHR) data encompass diverse modalities -- text, images, and medical codes -- that are vital for clinical decision-making. To process these complex data, multimodal AI (MAI) has emerged as a powerful approach for…

Machine Learning · Computer Science 2026-03-03 Nikkie Hooman , Zhongjie Wu , Eric C. Larson , Mehak Gupta

Alzheimer's dementia (AD) affects memory, thinking, and language, deteriorating person's life. An early diagnosis is very important as it enables the person to receive medical help and ensure quality of life. Therefore, leveraging…

Machine Learning · Computer Science 2023-04-06 Michail Chatzianastasis , Loukas Ilias , Dimitris Askounis , Michalis Vazirgiannis

Addressing missing modalities presents a critical challenge in multimodal learning. Current approaches focus on developing models that can handle modality-incomplete inputs during inference, assuming that the full set of modalities are…

Computer Vision and Pattern Recognition · Computer Science 2024-06-05 Yunpeng Zhao , Cheng Chen , Qing You Pang , Quanzheng Li , Carol Tang , Beng-Ti Ang , Yueming Jin

Effectively managing missing modalities is a fundamental challenge in real-world multimodal learning scenarios, where data incompleteness often results from systematic collection errors or sensor failures. Sparse Mixture-of-Experts (SMoE)…

Machine Learning · Computer Science 2026-05-12 Liangwei Nathan Zheng , Wei Emma Zhang , Mingyu Guo , Olaf Maennel , Weitong Chen