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Multimodal clinical prediction faces three challenges: multiple foundation models (FMs) with complementary strengths per modality, pervasive missing modalities at training and test time, and sample-specific variation in modality…

Machine Learning · Computer Science 2026-05-19 Seungik Cho , Anqi Li , Wei Qiu

Substantial advances in multi-modal Artificial Intelligence (AI) facilitate the combination of diverse medical modalities to achieve holistic health assessments. We present COMPRER , a novel multi-modal, multi-objective pretraining…

Computer Vision and Pattern Recognition · Computer Science 2024-03-18 Guy Lutsker , Hagai Rossman , Nastya Godiva , Eran Segal

Automated methods for Alzheimer's disease (AD) classification have the potential for great clinical benefits and may provide insight for combating the disease. Machine learning, and more specifically deep neural networks, have been shown to…

Alzheimer's disease (AD) is a progressive neurodegenerative disorder in which pathological changes begin many years before the onset of clinical symptoms, making early detection essential for timely intervention. T1-weighted (T1w) Magnetic…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Jason Qiu

Survival analysis, as a challenging task, requires integrating Whole Slide Images (WSIs) and genomic data for comprehensive decision-making. There are two main challenges in this task: significant heterogeneity and complex inter- and…

Image and Video Processing · Electrical Eng. & Systems 2024-06-17 Conghao Xiong , Hao Chen , Hao Zheng , Dong Wei , Yefeng Zheng , Joseph J. Y. Sung , Irwin King

Learning from multimodal datasets can leverage complementary information and improve performance in prediction tasks. A commonly used strategy to account for feature correlations in high-dimensional datasets is the latent variable approach.…

Machine Learning · Computer Science 2024-10-01 Lingchao Mao , Qi wang , Yi Su , Fleming Lure , Jing Li

Large Language Models (LLMs) are often English-centric due to the disproportionate distribution of languages in their pre-training data. Enhancing non-English language capabilities through post-pretraining often results in catastrophic…

Computation and Language · Computer Science 2024-08-22 Hao Zhou , Zhijun Wang , Shujian Huang , Xin Huang , Xue Han , Junlan Feng , Chao Deng , Weihua Luo , Jiajun Chen

Transfer learning has been widely utilized to mitigate the data scarcity problem in the field of Alzheimer's disease (AD). Conventional transfer learning relies on re-using models trained on AD-irrelevant tasks such as natural image…

Image and Video Processing · Electrical Eng. & Systems 2023-04-18 Kai Tzu-iunn Ong , Hana Kim , Minjin Kim , Jinseong Jang , Beomseok Sohn , Yoon Seong Choi , Dosik Hwang , Seong Jae Hwang , Jinyoung Yeo

We aim to develop a fundamental understanding of modality collapse, a recently observed empirical phenomenon wherein models trained for multimodal fusion tend to rely only on a subset of the modalities, ignoring the rest. We show that…

Machine Learning · Computer Science 2025-08-18 Abhra Chaudhuri , Anjan Dutta , Tu Bui , Serban Georgescu

Multi-Modal Entity Alignment aims to discover identical entities across heterogeneous knowledge graphs. While recent studies have delved into fusion paradigms to represent entities holistically, the elimination of features irrelevant to…

Computation and Language · Computer Science 2024-07-24 Yani Huang , Xuefeng Zhang , Richong Zhang , Junfan Chen , Jaein Kim

Multimodal emotion and intent recognition is essential for automated human-computer interaction, It aims to analyze users' speech, text, and visual information to predict their emotions or intent. One of the significant challenges is that…

Artificial Intelligence · Computer Science 2025-07-09 Wei Zhang , Juan Chen , Yanbo J. Wang , En Zhu , Xuan Yang , Yiduo Wang

Multivariate bounded discrete data arises in many fields. In the setting of dementia studies, such data is collected when individuals complete neuropsychological tests. We outline a modeling and inference procedure that can model the joint…

Methodology · Statistics 2026-02-10 Daniel Suen , Yen-Chi Chen

Multimodal emotion recognition (MER) is crucial for human-computer interaction, yet real-world challenges like dynamic modality incompleteness and asynchrony severely limit its robustness. Existing methods often assume consistently complete…

Human-Computer Interaction · Computer Science 2025-08-19 Yitong Zhu , Lei Han , Guanxuan Jiang , PengYuan Zhou , Yuyang Wang

We introduce SeePhys Pro, a fine-grained modality transfer benchmark that studies whether models preserve the same reasoning capability when critical information is progressively transferred from text to image. Unlike standard…

Brain transcriptomics provides insights into the molecular mechanisms by which the brain coordinates its functions and processes. However, existing multimodal methods for predicting Alzheimer's disease (AD) primarily rely on imaging and…

Artificial Intelligence · Computer Science 2025-04-03 Shan Cong , Zhoujie Fan , Hongwei Liu , Yinghan Zhang , Xin Wang , Haoran Luo , Xiaohui Yao

In real-world clinical settings, magnetic resonance imaging (MRI) frequently suffers from missing modalities due to equipment variability or patient cooperation issues, which can significantly affect model performance. To address this…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Zhejia Zhang , Junjie Wang , Le Zhang

Generative AI framework-based modeling and prediction of longitudinal human brain images offer an efficient mechanism to track neurodegenerative progression, essential for the assessment of diseases like Alzheimer's. Among the existing…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Ayantika Das , Keerthi Ram , Mohanasankar Sivaprakasam

Multimodal representation learning harmonizes distinct modalities by aligning them into a unified latent space. Recent research generalizes traditional cross-modal alignment to produce enhanced multimodal synergy but requires all modalities…

Computer Vision and Pattern Recognition · Computer Science 2026-05-13 Xiaohao Liu , Xiaobo Xia , Jiaheng Wei , Shuo Yang , Xiu Su , See-Kiong Ng , Tat-Seng Chua

Prediction Rule Ensembles (PREs) are robust and interpretable statistical learning techniques with potential for predictive analytics, yet their efficacy in the presence of missing data is untested. This study uses multiple imputation to…

Applications · Statistics 2024-10-22 Vincent Schroeder , Jakob Schwerter , Marjolein Fokkema , Philipp Doebler

Early diagnosis of Alzheimer's disease (AD) is critical for intervention before irreversible neurodegeneration occurs. Structural MRI (sMRI) is widely used for AD diagnosis, but conventional deep learning approaches primarily rely on…

Image and Video Processing · Electrical Eng. & Systems 2025-03-04 Shijia Zhang , Xiyu Ding , Brian Caffo , Junyu Chen , Cindy Zhang , Hadi Kharrazi , Zheyu Wang