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High throughput genome sequencing technologies such as RNA-Seq and Microarray have the potential to transform clinical decision making and biomedical research by enabling high-throughput measurements of the genome at a granular level.…

Since its selection as the method of the year in 2013, single-cell technologies have become mature enough to provide answers to complex research questions. With the growth of single-cell profiling technologies, there has also been a…

Machine learning (ML) offers powerful methods for detecting and modeling associations often in data with large feature spaces and complex associations. Many useful tools/packages (e.g. scikit-learn) have been developed to make the various…

Machine Learning · Computer Science 2022-06-27 Ryan J. Urbanowicz , Robert Zhang , Yuhan Cui , Pranshu Suri

Entity alignment has always had significant uses within a multitude of diverse scientific fields. In particular, the concept of matching entities across networks has grown in significance in the world of social science as communicative…

Social and Information Networks · Computer Science 2020-04-21 James Flamino , Christopher Abriola , Ben Zimmerman , Zhongheng Li , Joel Douglas

Background: With the rapid growth of massively parallel sequencing technologies, still more laboratories are utilizing sequenced DNA fragments for genomic analyses. Interpretation of sequencing data is, however, strongly dependent on…

Single-cell RNA sequencing (scRNA-seq) data analysis is pivotal for understanding cellular heterogeneity. However, the high sparsity and complex noise patterns inherent in scRNA-seq data present significant challenges for traditional…

Genomics · Quantitative Biology 2024-08-13 Wenwen Min , Zhen Wang , Fangfang Zhu , Taosheng Xu , Shunfang Wang

The paper presents a new model for single channel images low-level interpretation. The image is decomposed into a graph which captures a complete set of structural features. The description allows to accurately identify every edge location…

Computer Vision and Pattern Recognition · Computer Science 2019-04-23 Alessandro Dal Palu'

Single-cell RNA sequencing (scRNA-seq) has revolutionized our ability to study individual cellular distinctions and uncover unique cell characteristics. However, a significant technical challenge in scRNA-seq analysis is the occurrence of…

Genomics · Quantitative Biology 2024-07-25 Yoshitaka Inoue

Recent advancements in data stream processing frameworks have improved real-time data handling, however, scalability remains a significant challenge affecting throughput and latency. While studies have explored this issue on local machines…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-04-04 Apurv Deepak Kulkarni , Siavash Ghiasvand

Time series shapelets are discriminative subsequences that have been recently found effective for time series clustering (TSC). The shapelets are convenient for interpreting the clusters. Thus, the main challenge for TSC is to discover…

Machine Learning · Computer Science 2022-08-19 Guozhong Li , Byron Choi , Jianliang Xu , Sourav S Bhowmick , Daphne Ngar-yin Mah , Grace Lai-Hung Wong

Statistical shape modeling is the computational process of discovering significant shape parameters from segmented anatomies captured by medical images (such as MRI and CT scans), which can fully describe subject-specific anatomy in the…

Computer Vision and Pattern Recognition · Computer Science 2023-08-01 Krithika Iyer , Shireen Elhabian

In plant phenotyping, accurate trait extraction from 3D point clouds of trees is still an open problem. For automatic modeling and trait extraction of tree organs such as blossoms and fruits, the semantically segmented point cloud of a tree…

Computer Vision and Pattern Recognition · Computer Science 2023-08-21 Lukas Meyer , Andreas Gilson , Oliver Scholz , Marc Stamminger

Geometry and topology constitute complementary descriptors of three-dimensional shape, yet existing benchmark datasets primarily capture geometric information while neglecting topological structure. This work addresses this limitation by…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Prachi Kudeshia , Jiju Poovvancheri

Identifying trendline visualizations with desired patterns is a common and fundamental data exploration task. Existing visual analytics tools offer limited flexibility and expressiveness for such tasks, especially when the pattern of…

Databases · Computer Science 2020-01-31 Tarique Siddiqui , Zesheng Wang , Paul Luh , Karrie Karahalios , Aditya Parameswaran

Single-cell RNA sequencing (scRNA-seq) has revolutionized our ability to analyze gene expression at the cellular level. By providing data on gene expression for each individual cell, scRNA-seq generates large datasets with thousands of…

Computational Complexity · Computer Science 2025-02-11 Md Romizul Islam , Swakkhar Shatabda

Model cards describe model behavior through a mixture of textual descriptions and structured artifacts, including performance, configuration, and dataset tables. Existing model search systems rely predominantly on semantic similarity over…

Information Retrieval · Computer Science 2026-05-22 Zhengyuan Dong , Renée J. Miller

This paper focuses on the challenging task of learning 3D object surface reconstructions from single RGB images. Existing methods achieve varying degrees of success by using different geometric representations. However, they all have their…

Computer Vision and Pattern Recognition · Computer Science 2019-04-11 Jiapeng Tang , Xiaoguang Han , Junyi Pan , Kui Jia , Xin Tong

Identifying cell clusters is a critical step for single-cell transcriptomics study. Despite the numerous clustering tools developed recently, the rapid growth of scRNA-seq volumes prompts for a more (computationally) efficient clustering…

Quantitative Methods · Quantitative Biology 2023-01-11 Nana Wei , Yating Nie , Lin Liu , Xiaoqi Zheng , Hua-Jun Wu4

Analyzing and visualizing scientific ensemble datasets with high dimensionality and complexity poses significant challenges. Dimensionality reduction techniques and autoencoders are powerful tools for extracting features, but they often…

Machine Learning · Computer Science 2026-01-19 Hamid Gadirov , Lennard Manuel , Steffen Frey

Recent advances in 3D imaging technologies provide novel insights to researchers and reveal finer and more detail of examined specimen, especially in the biomedical domain, but also impose huge challenges regarding scalability for automated…

Computer Vision and Pattern Recognition · Computer Science 2021-06-30 Dominik Drees , Aaron Scherzinger , René Hägerling , Friedemann Kiefer , Xiaoyi Jiang