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Identifying enzymes that catalyze target biochemical reactions is a key step in computational enzyme discovery and biocatalyst design. Recent representation-learning methods formulate this problem as enzyme--reaction matching, where paired…

Biomolecules · Quantitative Biology 2026-05-26 Gengmo Zhou , Feng Yu , Wenda Wang , Zhifeng Gao , Guolin Ke , Zhewei Wei , Zhen Wang

In neutrino physics, analyses often depend on large simulated datasets, making it essential for models to generalise effectively to real-world detector data. Contrastive learning, a well-established technique in deep learning, offers a…

High Energy Physics - Experiment · Physics 2025-05-23 Alex Wilkinson , Radi Radev , Saul Alonso-Monsalve

Nuclear Magnetic Resonance (NMR) spectroscopy is particularly well-suited to determine the structure of molecules and materials in powdered form. Structure determination usually proceeds by finding the best match between experimentally…

Nuclear Magnetic Resonance (NMR) chemical shifts are powerful probes of local atomic and electronic structure that can be used to resolve the structures of powdered or amorphous molecular solids. Chemical shift driven structure elucidation…

Rapid determination of molecular structures can greatly accelerate workflows across many chemical disciplines. However, elucidating structure using only one-dimensional (1D) NMR spectra, the most readily accessible data, remains an…

Chemical Physics · Physics 2024-08-16 Frank Hu , Michael S. Chen , Grant M. Rotskoff , Matthew W. Kanan , Thomas E. Markland

Chemical representation learning has gained increasing interest due to the limited availability of supervised data in fields such as drug and materials design. This interest particularly extends to chemical language representation learning,…

Chemical Physics · Physics 2024-08-06 Jun-Hyung Park , Yeachan Kim , Mingyu Lee , Hyuntae Park , SangKeun Lee

Self-supervised learning, especially contrastive learning, has made an outstanding contribution to the development of many deep learning research fields. Recently, researchers in the acoustic signal processing field noticed its success and…

Sound · Computer Science 2022-04-05 Dong Yao , Zhou Zhao , Shengyu Zhang , Jieming Zhu , Yudong Zhu , Rui Zhang , Xiuqiang He

Machine learning in atomistic materials science has grown to become a powerful tool, with most approaches focusing on atomic arrangements, typically decomposed into local atomic environments. This approach, while well-suited for…

Materials Science · Physics 2025-03-12 Austin Zadoks , Antimo Marrazzo , Nicola Marzari

The scarcity of annotated data has sparked significant interest in unsupervised pre-training methods that leverage medical reports as auxiliary signals for medical visual representation learning. However, existing research overlooks the…

Computer Vision and Pattern Recognition · Computer Science 2024-02-06 Zhe Li , Laurence T. Yang , Bocheng Ren , Xin Nie , Zhangyang Gao , Cheng Tan , Stan Z. Li

We present a unified vision-language framework tailored for ENT endoscopy image analysis that simultaneously tackles three clinically-relevant tasks: image classification, image-to-image retrieval, and text-to-image retrieval. Unlike…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Y Hop Nguyen , Doan Anh Phan Huu , Trung Thai Tran , Nhat Nam Mai , Van Toi Giap , Thao Thi Phuong Dao , Trung-Nghia Le

Nuclear magnetic resonance (NMR) spectroscopy provides detailed information pertaining to dynamic processes through line-shape changes, which have been traditionally limited to equilibrium conditions. However, there is a wealth of…

Evaluating the (dis)similarity of crystalline, disordered and molecular compounds is a critical step in the development of algorithms to navigate automatically the configuration space of complex materials. For instance, a structural…

Materials Science · Physics 2020-02-06 Sandip De , Albert P. Bartók , Gábor Csányi , Michele Ceriotti

This paper presents SimCLR: a simple framework for contrastive learning of visual representations. We simplify recently proposed contrastive self-supervised learning algorithms without requiring specialized architectures or a memory bank.…

Machine Learning · Computer Science 2020-07-02 Ting Chen , Simon Kornblith , Mohammad Norouzi , Geoffrey Hinton

One-dimensional NMR spectroscopy is one of the most widely used techniques for the characterization of organic compounds and natural products. For molecules with up to 36 non-hydrogen atoms, the number of possible structures has been…

While deep learning has enabled great advances in many areas of music, labeled music datasets remain especially hard, expensive, and time-consuming to create. In this work, we introduce SimCLR to the music domain and contribute a large…

Sound · Computer Science 2021-09-28 Janne Spijkervet , John Ashley Burgoyne

One-dimensional nuclear magnetic resonance (NMR) spectroscopy is essential for molecular structure elucidation in organic synthesis, drug discovery, natural product characterization, and metabolomics, yet its interpretation remains heavily…

Molecular shape and geometry dictate key biophysical recognition processes, yet many graph neural networks disregard 3D information for molecular property prediction. Here, we propose a new contrastive-learning procedure for graph neural…

Machine Learning · Computer Science 2022-11-07 Austin Atsango , Nathaniel L. Diamant , Ziqing Lu , Tommaso Biancalani , Gabriele Scalia , Kangway V. Chuang

Characterization of the molecular properties of surfaces under ambient or chemically reactive conditions is a fundamental scientific challenge. Moreover, many traditional analytical techniques used for probing surfaces often lack dynamic or…

Nuclear Magnetic Resonance (NMR) spectroscopy is a crucial analytical technique used for molecular structure elucidation, with applications spanning chemistry, biology, materials science, and medicine. However, the frequency resolution of…

Contrastive learning (CL) has shown impressive advances in image representation learning in whichever supervised multi-class classification or unsupervised learning. However, these CL methods fail to be directly adapted to multi-label image…

Computer Vision and Pattern Recognition · Computer Science 2022-09-07 Zhongchen Ma , Lisha Li , Qirong Mao , Songcan Chen