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Causal representation learning (CRL) offers the promise of uncovering the underlying causal model by which observed data was generated, but the practical applicability of existing methods remains limited by the strong assumptions required…

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Optically active spin defects in solids offer promising platforms to investigate nuclear spin clusters with high sensitivity and atomic-site resolution. To leverage near-surface defects for molecular structure analysis in chemical and…

Scanning probe microscopy is one of the most versatile windows into the nanoworld, providing imaging access to a variety of sample properties, depending on the probe employed. Tunneling probes map electronic properties of samples, magnetic…

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Modeling the relationship between chemical structure and molecular activity is a key goal in drug development. Many benchmark tasks have been proposed for molecular property prediction, but these tasks are generally aimed at specific,…

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To date, the most common approach for radiology deep learning pipelines is the use of end-to-end 3D networks based on models pre-trained on other tasks, followed by fine-tuning on the task at hand. In contrast, adjacent medical fields such…

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A proof-of-concept framework for identifying molecules of unknown elemental composition and structure using experimental rotational data and probabilistic deep learning is presented. Using a minimal set of input data determined…

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Identifying unique characteristics in a network through comparison with another network is an essential network analysis task. For example, with networks of protein interactions obtained from normal and cancer tissues, we can discover…

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Many biochemical applications such as molecular property prediction require models to generalize beyond their training domains (environments). Moreover, natural environments in these tasks are structured, defined by complex descriptors such…

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Particle accelerators are complex systems that focus, guide, and accelerate intense charged particle beams to high energy. Beam diagnostics present a challenging problem due to limited non-destructive measurements, computationally demanding…

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Vision-Language Models (VLMs), such as CLIP, exhibit strong image-text comprehension abilities, facilitating advances in several downstream tasks such as zero-shot image classification, image-text retrieval, and text-to-image generation.…

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Pre-trained language models (PLMs) have made significant advances in natural language inference (NLI) tasks, however their sensitivity to textual perturbations and dependence on large datasets indicate an over-reliance on shallow…

Machine Learning · Computer Science 2025-02-14 Mingyue Liu , Ryo Ueda , Zhen Wan , Katsumi Inoue , Chris G. Willcocks

A chemical reaction mechanism (CRM) is a sequence of molecular-level events involving bond-breaking/forming processes, generating transient intermediates along the reaction pathway as reactants transform into products. Understanding such…

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Contrastive learning (CL) methods effectively learn data representations in a self-supervision manner, where the encoder contrasts each positive sample over multiple negative samples via a one-vs-many softmax cross-entropy loss. By…

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Although multi-scales representation learning enables elastic-dimension embeddings, nested subspaces often suffer from dimensional redundancy and spectral collapse. To address this, we introduce MIC, a framework that optimizes the geometric…

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Machine learning has the potential to automate molecular design and drastically accelerate the discovery of new functional compounds. Towards this goal, generative models and reinforcement learning (RL) using string and graph…

Machine Learning · Computer Science 2022-02-02 Daniel Flam-Shepherd , Alexander Zhigalin , Alán Aspuru-Guzik

Contrastive learning has emerged as a pivotal framework for representation learning, underpinning advances in both unimodal and bimodal applications like SimCLR and CLIP. To address fundamental limitations like large batch size dependency…

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Non-intrusive load monitoring (NILM) aims at energy consumption and appliance state information retrieval from aggregated consumption measurements, with the help of signal processing and machine learning algorithms. Representation learning…

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Transition metal chromophores with earth-abundant transition metals are an important design target for their applications in lighting and non-toxic bioimaging, but their design is challenged by the scarcity of complexes that simultaneously…

Chemical Physics · Physics 2022-09-16 Chenru Duan , Aditya Nandy , Gianmarco Terrones , David W. Kastner , Heather J. Kulik

Crystal structures are characterised by repeating atomic patterns within unit cells across three-dimensional space, posing unique challenges for graph-based representation learning. Current methods often overlook essential periodic boundary…

Molecular representation learning is pivotal in predicting molecular properties and advancing drug design. Traditional methodologies, which predominantly rely on homogeneous graph encoding, are limited by their inability to integrate…

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