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Background: The surge in single-cell omics data exposes limitations in traditional, manually defined analysis workflows. AI agents offer a paradigm shift, enabling adaptive planning, executable code generation, traceable decisions, and…

Genomics · Quantitative Biology 2026-03-17 Yang Liu , Lu Zhou , Xiawei Du , Ruikun He , Xuguang Zhang , Rongbo Shen , Yixue Li

In recent years, advances in artificial intelligence (AI), particularly generative AI (GenAI) and large language models (LLMs), have made human-computer interactions more frequent, efficient, and accessible across sectors ranging from…

Computers and Society · Computer Science 2025-12-19 Przemek Pospieszny , Dominika P. Brodowicz

Agentic AI rivals human capabilities across a wide range of domains. Looking ahead, it is foreseeable that AI agents will autonomously handle complex workflows and interactions. Early prototypes of this paradigm are emerging, e.g., OpenClaw…

Reasoning is a fundamental cognitive process underlying inference, problem-solving, and decision-making. While large language models (LLMs) demonstrate strong reasoning capabilities in closed-world settings, they struggle in open-ended and…

State-of-the-art large language models require specialized hardware and substantial energy to operate. As a consequence, cloud-based services that provide access to large language models have become very popular. In these services, the…

Computer Science and Game Theory · Computer Science 2026-05-29 Ander Artola Velasco , Stratis Tsirtsis , Nastaran Okati , Manuel Gomez-Rodriguez

The emergence of agentic reinforcement learning (Agentic RL) marks a paradigm shift from conventional reinforcement learning applied to large language models (LLM RL), reframing LLMs from passive sequence generators into autonomous,…

Large Language Models (LLMs) open new possibilities for constructing realistic and interpretable macroeconomic simulations. We present SimCity, a multi-agent framework that leverages LLMs to model an interpretable macroeconomic system with…

Multiagent Systems · Computer Science 2026-04-06 Yeqi Feng , Yucheng Lu , Hongyu Su , Yixin Tao , Tianxing He

The rapid development of large language model (LLM)-based agents has unlocked new possibilities for autonomous multi-turn reasoning and tool-augmented decision-making. However, their real-world deployment is hindered by severe…

As Large Language Models (LLMs) gain agentic abilities, they will have to navigate complex multi-agent scenarios, interacting with human users and other agents in cooperative and competitive settings. This will require new reasoning skills,…

Artificial Intelligence · Computer Science 2025-06-26 Andrei Lupu , Timon Willi , Jakob Foerster

The rapid rise of AI-based autonomous agents is transforming human society and economic systems, as these entities increasingly exhibit human-like or superhuman intelligence. From excelling at complex games like Go to tackling diverse…

Artificial Intelligence · Computer Science 2025-05-27 Ke Yang , ChengXiang Zhai

In this article we survey the main research topics of our group at the University of Essex. Our research interests lie at the intersection of theoretical computer science, artificial intelligence, and economic theory. In particular, we…

Computer Science and Game Theory · Computer Science 2022-10-10 Michael Kampouridis , Panagiotis Kanellopoulos , Maria Kyropoulou , Themistoklis Melissourgos , Alexandros A. Voudouris

Advances in large language models have enabled agentic AI systems that can reason, plan, and interact with external tools to execute multi-step workflows, while public blockchains have evolved into a programmable substrate for value…

Artificial Intelligence · Computer Science 2026-01-09 Saad Alqithami

Large language models (LLMs) can serve as the semantic-matching engine of a content-based publish/subscribe broker for agentic AI across the edge-cloud computing continuum, bridging the vocabulary and modality gaps that defeat keyword and…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-05-26 Lauri Lovén , Abhishek Kumar , Alexander Engelhardt , Alaa Saleh , Roberto Morabito , Xiaoli Liu , Naser Hossein Motlagh , Sasu Tarkoma

Reasoning is a fundamental cognitive process that enables logical inference, problem-solving, and decision-making. With the rapid advancement of large language models (LLMs), reasoning has emerged as a key capability that distinguishes…

AI agents are beginning to interact with each other directly and across internet platforms and physical environments, creating security challenges beyond traditional cybersecurity and AI safety frameworks. Free-form protocols are essential…

With recent advances in Large Language Models (LLMs), Agentic AI has become phenomenal in real-world applications, moving toward multiple LLM-based agents to perceive, learn, reason, and act collaboratively. These LLM-based Multi-Agent…

Artificial Intelligence · Computer Science 2025-01-14 Khanh-Tung Tran , Dung Dao , Minh-Duong Nguyen , Quoc-Viet Pham , Barry O'Sullivan , Hoang D. Nguyen

AI agents powered by large language models (LLMs) are being deployed at scale, yet we lack a systematic understanding of how the choice of backbone LLM affects agent security. The non-deterministic sequential nature of AI agents complicates…

Cryptography and Security · Computer Science 2026-02-25 Julia Bazinska , Max Mathys , Francesco Casucci , Mateo Rojas-Carulla , Xander Davies , Alexandra Souly , Niklas Pfister

Agentic AI systems, which leverage multiple autonomous agents and large language models (LLMs), are increasingly used to address complex, multi-step tasks. The safety, security, and functionality of these systems are critical, especially in…

Artificial Intelligence · Computer Science 2026-04-16 Edoardo Allegrini , Ananth Shreekumar , Z. Berkay Celik

Understanding decision-making in multi-AI-agent frameworks is crucial for analyzing strategic interactions in network-effect-driven contexts. This study investigates how AI agents navigate network-effect games, where individual payoffs…

Multiagent Systems · Computer Science 2025-12-16 Yu Liu , Wenwen Li , Yifan Dou , Guangnan Ye

As scientific research becomes increasingly complex, innovative tools are needed to manage vast data, facilitate interdisciplinary collaboration, and accelerate discovery. Large language models (LLMs) are now evolving into LLM-based…

Artificial Intelligence · Computer Science 2026-02-03 Shuo Ren , Can Xie , Pu Jian , Zhenjiang Ren , Chunlin Leng , Jiajun Zhang