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Vision-language models (VLMs) have shown strong promise for medical image analysis, but most remain opaque, offering predictions without the transparent, stepwise reasoning clinicians rely on. We present a framework that brings…

Computer Vision and Pattern Recognition · Computer Science 2025-10-31 Andriy Myronenko , Dong Yang , Baris Turkbey , Mariam Aboian , Sena Azamat , Esra Akcicek , Hongxu Yin , Pavlo Molchanov , Marc Edgar , Yufan He , Pengfei Guo , Yucheng Tang , Daguang Xu

The concept bottleneck model (CBM), as a technique improving interpretability via linking predictions to human-understandable concepts, makes high-risk and life-critical medical image classification credible. Typically, existing CBM methods…

Computer Vision and Pattern Recognition · Computer Science 2025-06-17 Chunjiang Wang , Kun Zhang , Yandong Liu , Zhiyang He , Xiaodong Tao , S. Kevin Zhou

Chest X-rays (CXRs) are the most frequently performed imaging examinations in clinical settings. Recent advancements in Large Multimodal Models (LMMs) have enabled automated CXR interpretation, enhancing diagnostic accuracy and efficiency.…

Computer Vision and Pattern Recognition · Computer Science 2025-05-06 Qingqiu Li , Zihang Cui , Seongsu Bae , Jilan Xu , Runtian Yuan , Yuejie Zhang , Rui Feng , Quanli Shen , Xiaobo Zhang , Junjun He , Shujun Wang

Model explainability is essential for the creation of trustworthy Machine Learning models in healthcare. An ideal explanation resembles the decision-making process of a domain expert and is expressed using concepts or terminology that is…

Machine Learning · Computer Science 2021-07-14 Sumedha Singla , Stephen Wallace , Sofia Triantafillou , Kayhan Batmanghelich

There has been considerable recent interest in interpretable concept-based models such as Concept Bottleneck Models (CBMs), which first predict human-interpretable concepts and then map them to output classes. To reduce reliance on…

Machine Learning · Computer Science 2024-07-08 Simon Schrodi , Julian Schur , Max Argus , Thomas Brox

Concept Bottleneck Models (CBMs) enhance the interpretability of AI systems, particularly by bridging visual input with human-understandable concepts, effectively acting as a form of multimodal interpretability model. However, existing CBMs…

Machine Learning · Computer Science 2025-08-06 Songning Lai , Mingqian Liao , Zhangyi Hu , Jiayu Yang , Wenshuo Chen , Hongru Xiao , Jianheng Tang , Haicheng Liao , Yutao Yue

Concept Bottleneck Models (CBMs) decompose image classification into a process governed by interpretable, human-readable concepts. Recent advances in CBMs have used Large Language Models (LLMs) to generate candidate concepts. However, a…

Computation and Language · Computer Science 2025-06-03 Yiwen Jiang , Deval Mehta , Wei Feng , Zongyuan Ge

Concept Bottleneck Models (CBMs) aim for ante-hoc interpretability by learning a bottleneck layer that predicts interpretable concepts before the decision. State-of-the-art approaches typically select which concepts to learn via human…

Machine Learning · Computer Science 2026-03-10 Antonio De Santis , Schrasing Tong , Marco Brambilla , Lalana Kagal

Concept bottleneck models (CBMs) improve neural network interpretability by introducing an intermediate layer that maps human-understandable concepts to predictions. Recent work has explored the use of vision-language models (VLMs) to…

Computer Vision and Pattern Recognition · Computer Science 2026-03-20 Xingbo Du , Qiantong Dou , Lei Fan , Rui Zhang

Recent concept-based interpretable models have succeeded in providing meaningful explanations by pre-defined concept sets. However, the dependency on the pre-defined concepts restricts the application because of the limited number of…

Artificial Intelligence · Computer Science 2025-02-19 Shin'ya Yamaguchi , Kosuke Nishida

The concept bottleneck model (CBM) is an interpretable-by-design framework that makes decisions by first predicting a set of interpretable concepts, and then predicting the class label based on the given concepts. Existing CBMs are trained…

Computer Vision and Pattern Recognition · Computer Science 2024-08-06 Andong Tan , Fengtao Zhou , Hao Chen

The chest X-ray (CXR) is one of the most common and easy-to-get medical tests used to diagnose common diseases of the chest. Recently, many deep learning-based methods have been proposed that are capable of effectively classifying CXRs.…

Image and Video Processing · Electrical Eng. & Systems 2023-05-23 Weizhi Nie , Chen Zhang , Dan Song , Lina Zhao , Yunpeng Bai , Keliang Xie , Anan Liu

Enhancing model interpretability can address spurious correlations by revealing how models draw their predictions. Concept Bottleneck Models (CBMs) can provide a principled way of disclosing and guiding model behaviors through…

Machine Learning · Computer Science 2024-07-15 Jeeyung Kim , Ze Wang , Qiang Qiu

Explainable AI seeks to bring light to the decision-making processes of black-box models. Traditional saliency-based methods, while highlighting influential data segments, often lack semantic understanding. Recent advancements, such as…

Artificial Intelligence · Computer Science 2023-10-12 Bo Pan , Zhenke Liu , Yifei Zhang , Liang Zhao

Recently impressive performance has been achieved in Concept Bottleneck Models (CBM) by utilizing the image-text alignment learned by a large pre-trained vision-language model (i.e. CLIP). However, there exist two key limitations in concept…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Minghong Zhong , Guoshuai Zou , Kanghao Chen , Dexia Chen , Ruixuan Wang

Deep learning models have achieved remarkable accuracy in chest X-ray diagnosis, yet their widespread clinical adoption remains limited by the black-box nature of their predictions. Clinicians require transparent, verifiable explanations to…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Yiming Tang , Wenjia Zhong , Rushi Shah , Dianbo Liu

Due to the high stakes in medical decision-making, there is a compelling demand for interpretable deep learning methods in medical image analysis. Concept Bottleneck Models (CBM) have emerged as an active interpretable framework…

Computer Vision and Pattern Recognition · Computer Science 2024-06-28 Yibo Gao , Zheyao Gao , Xin Gao , Yuanye Liu , Bomin Wang , Xiahai Zhuang

Concept Bottleneck Models (CBMs) introduce interpretability to black-box deep learning models by predicting labels through human-understandable concepts. However, unlike humans, who identify objects at different levels of abstraction using…

Computer Vision and Pattern Recognition · Computer Science 2026-04-06 Haodong Xie , Yujun Cai , Rahul Singh Maharjan , Yiwei Wang , Federico Tavella , Angelo Cangelosi

With the increasing demands for accountability, interpretability is becoming an essential capability for real-world AI applications. However, most methods utilize post-hoc approaches rather than training the interpretable model. In this…

Computer Vision and Pattern Recognition · Computer Science 2022-02-04 Yoshihide Sawada , Keigo Nakamura

Existing methods, such as concept bottleneck models (CBMs), have been successful in providing concept-based interpretations for black-box deep learning models. They typically work by predicting concepts given the input and then predicting…

Computer Vision and Pattern Recognition · Computer Science 2025-01-03 Xinyue Xu , Yi Qin , Lu Mi , Hao Wang , Xiaomeng Li