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The rapid development of digital pathology and modern deep learning has facilitated the emergence of pathology foundation models that are expected to solve general pathology problems under various disease conditions in one unified model,…

Computer Vision and Pattern Recognition · Computer Science 2025-07-10 Yutong Sun , Sichen Zhu , Peng Qiu

Recent advances in Spatial Transcriptomics (ST) pair histology images with spatially resolved gene expression profiles, enabling predictions of gene expression across different tissue locations based on image patches. This opens up new…

Computer Vision and Pattern Recognition · Computer Science 2025-03-21 Aniruddha Ganguly , Debolina Chatterjee , Wentao Huang , Jie Zhang , Alisa Yurovsky , Travis Steele Johnson , Chao Chen

Spatial Transcriptomics (ST) provides spatially-resolved gene expression, offering crucial insights into tissue architecture and complex diseases. However, its prohibitive cost limits widespread adoption, leading to significant attention on…

Computer Vision and Pattern Recognition · Computer Science 2026-03-27 Taejin Jeong , Joohyeok Kim , Jinyeong Kim , Chanyoung Kim , Seong Jae Hwang

The technology to generate Spatially Resolved Transcriptomics (SRT) data is rapidly being improved and applied to investigate a variety of biological tissues. The ability to interrogate how spatially localised gene expression can lend new…

Quantitative Methods · Quantitative Biology 2021-08-04 Natalie Charitakis , Mirana Ramialison , Hieu T. Nim

Weather Forecasting is an attractive challengeable task due to its influence on human life and complexity in atmospheric motion. Supported by massive historical observed time series data, the task is suitable for data-driven approaches,…

Machine Learning · Computer Science 2022-09-20 Minbo Ma , Peng Xie , Fei Teng , Tianrui Li , Bin Wang , Shenggong Ji , Junbo Zhang

Spatial transcriptomics enables gene expression profiling with spatial context, offering unprecedented insights into the tissue microenvironment. However, most computational models treat genes as isolated numerical features, ignoring the…

Machine Learning · Computer Science 2025-11-17 Jiangkai Long , Yanran Zhu , Chang Tang , Kun Sun , Yuanyuan Liu , Xuesong Yan

With the emergence of advanced spatial transcriptomic technologies, there has been a surge in research papers dedicated to analyzing spatial transcriptomics data, resulting in significant contributions to our understanding of biology. The…

Genomics · Quantitative Biology 2024-04-11 Sikta Das Adhikari , Jiaxin Yang , Jianrong Wang , Yuehua Cui

Accurately predicting gene expression from histopathology images offers a scalable and non-invasive approach to molecular profiling, with significant implications for precision medicine and computational pathology. However, existing methods…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Yaxuan Song , Jianan Fan , Hang Chang , Weidong Cai

Spatial transcriptomics (ST) enables mapping gene expression with spatial context but is severely affected by high sparsity and technical noise, which conceals true biological signals and hinders downstream analyses. To address these…

Machine Learning · Computer Science 2026-03-10 Sayeem Bin Zaman , Fahim Hafiz , Riasat Azim

Recent years have witnessed remarkable progress in multimodal learning within computational pathology. Existing models primarily rely on vision and language modalities; however, language alone lacks molecular specificity and offers limited…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Minghao Han , Dingkang Yang , Linhao Qu , Zizhi Chen , Gang Li , Han Wang , Jiacong Wang , Lihua Zhang

Space-Time Projection (STP) is introduced as a data-driven forecasting approach for high-dimensional and time-resolved data. The method computes extended space-time proper orthogonal modes from training data spanning a prediction horizon…

Machine Learning · Computer Science 2025-04-01 Oliver T. Schmidt

Hyperspectral image super-resolution has attained widespread prominence to enhance the spatial resolution of hyperspectral images. However, convolution-based methods have encountered challenges in harnessing the global spatial-spectral…

Image and Video Processing · Electrical Eng. & Systems 2023-11-30 Shi Chen , Lefei Zhang , Liangpei Zhang

Spatially resolved transcriptomics represents a significant advancement in single-cell analysis by offering both gene expression data and their corresponding physical locations. However, this high degree of spatial resolution entails a…

Genomics · Quantitative Biology 2024-03-19 Xiaoyu Li , Wenwen Min , Shunfang Wang , Changmiao Wang , Taosheng Xu

Transformer-based models, capable of learning better global dependencies, have recently demonstrated exceptional representation learning capabilities in computer vision and medical image analysis. Transformer reformats the image into…

Accurate long-term predictions are the foundations for many machine learning applications and decision-making processes. Traditional time series approaches for prediction often focus on either autoregressive modeling, which relies solely on…

Machine Learning · Computer Science 2025-04-22 Kshitij Tayal , Arvind Renganathan , Xiaowei Jia , Vipin Kumar , Dan Lu

Numerous industrial sectors necessitate models capable of providing robust forecasts across various horizons. Despite the recent strides in crafting specific architectures for time-series forecasting and developing pre-trained universal…

Machine Learning · Computer Science 2024-11-05 Jiawen Zhang , Shun Zheng , Xumeng Wen , Xiaofang Zhou , Jiang Bian , Jia Li

X-ray Photoelectron Spectroscopy (XPS) is a crucial technique for material surface analysis, yet interpreting its spectra is often challenging for both human analysts and automated methods due to the prevalence of variable spectral shifts…

Materials Science · Physics 2026-03-06 Issa Saddiq , Yuxin Fan , Robert G. Palgrave , Mark A. Isaacs , David Morgan , Keith T. Butler

Among various region embedding methods, graph-based region relation learning models stand out, owing to their strong structure representation ability for encoding spatial correlations with graph neural networks. Despite their effectiveness,…

Machine Learning · Computer Science 2023-05-09 Qianru Zhang , Chao Huang , Lianghao Xia , Zheng Wang , Zhonghang Li , Siuming Yiu

Spatial transcriptomic (ST) clustering employs spatial and transcription information to group spots spatially coherent and transcriptionally similar together into the same spatial domain. Graph convolution network (GCN) and graph attention…

Quantitative Methods · Quantitative Biology 2023-10-24 Chen Zhang , Junhui Gao , Lingxin Kong , Guangshuo cao , Xiangyu Guo , Wei Liu

3D Swin Transformer (3D-ST) known for its hierarchical attention and window-based processing, excels in capturing intricate spatial relationships within images. Spatial-spectral Transformer (SST), meanwhile, specializes in modeling…

Computer Vision and Pattern Recognition · Computer Science 2024-09-27 Muhammad Ahmad , Manuel Mazzara , Salvatore Distifano
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