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The integration of Large Language Models (LLMs) into healthcare demands a safety paradigm rooted in \textit{primum non nocere}. However, current alignment techniques rely on generic definitions of harm that fail to capture context-dependent…

Computers and Society · Computer Science 2025-12-01 Andrew Maranhão Ventura D'addario

Prompt injection attacks exploit vulnerabilities in large language models (LLMs) to manipulate the model into unintended actions or generate malicious content. As LLM integrated applications gain wider adoption, they face growing…

Cryptography and Security · Computer Science 2024-01-03 Daniel Wankit Yip , Aysan Esmradi , Chun Fai Chan

As generative AI systems, including large language models (LLMs) and diffusion models, advance rapidly, their growing adoption has led to new and complex security risks often overlooked in traditional AI risk assessment frameworks. This…

Cryptography and Security · Computer Science 2024-10-21 Aviral Srivastava , Sourav Panda

Large Language Models (LLMs) are increasingly used for decision making in embodied agents, yet existing safety evaluations often rely on coarse success rates and domain-specific setups, making it difficult to diagnose why and where these…

Artificial Intelligence · Computer Science 2025-05-27 Yejin Son , Minseo Kim , Sungwoong Kim , Seungju Han , Jian Kim , Dongju Jang , Youngjae Yu , Chanyoung Park

Large Language Models (LLMs) are increasingly used for clinical decision support, where hallucinations and unsafe suggestions may pose direct risks to patient safety. These risks are hard to assess: subtle clinical errors are often missed…

Computation and Language · Computer Science 2026-05-14 Yinzhu Chen , Abdine Maiga , Hossein A. Rahmani , Emine Yilmaz

This paper explores the use of large language models (LLMs) to assist in the development of new disease modules for Synthea, an open-source synthetic health data generator. Incorporating LLMs into the module development process has the…

Artificial Intelligence · Computer Science 2025-07-30 Mark A. Kramer , Aanchal Mathur , Caroline E. Adams , Jason A. Walonoski

Numerous medical systems powered by Large Language Models (LLMs) have achieved remarkable progress in diverse healthcare tasks. However, research on their medication safety remains limited due to the lack of real world datasets, constrained…

Artificial Intelligence · Computer Science 2025-11-07 Jiahao Zhao , Luxin Xu , Minghuan Tan , Lichao Zhang , Ahmadreza Argha , Hamid Alinejad-Rokny , Min Yang

Multimodal Large Language Models (MLLMs) are showing strong safety concerns (e.g., generating harmful outputs for users), which motivates the development of safety evaluation benchmarks. However, we observe that existing safety benchmarks…

Cryptography and Security · Computer Science 2024-10-25 Zonghao Ying , Aishan Liu , Siyuan Liang , Lei Huang , Jinyang Guo , Wenbo Zhou , Xianglong Liu , Dacheng Tao

Fault cause identification in automated manufacturing lines is challenging due to the system's complexity, frequent reconfigurations, and the limited reusability of existing Failure Mode and Effects Analysis (FMEA) knowledge. Although FMEA…

Information Retrieval · Computer Science 2025-10-20 Sho Okazaki , Kohei Kaminishi , Takuma Fujiu , Yusheng Wang , Jun Ota

Large language models (LLMs) are emerging as promising tools for mental health care, offering scalable support through their ability to generate human-like responses. However, the effectiveness of these models in clinical settings remains…

Artificial Intelligence · Computer Science 2024-08-22 Yining Hua , Hongbin Na , Zehan Li , Fenglin Liu , Xiao Fang , David Clifton , John Torous

Large language models (LLMs) have strong capabilities in solving diverse natural language processing tasks. However, the safety and security issues of LLM systems have become the major obstacle to their widespread application. Many studies…

Computation and Language · Computer Science 2024-01-12 Tianyu Cui , Yanling Wang , Chuanpu Fu , Yong Xiao , Sijia Li , Xinhao Deng , Yunpeng Liu , Qinglin Zhang , Ziyi Qiu , Peiyang Li , Zhixing Tan , Junwu Xiong , Xinyu Kong , Zujie Wen , Ke Xu , Qi Li

Large language model-powered chatbots have transformed how people seek information, especially in high-stakes contexts like mental health. Despite their support capabilities, safe detection and response to crises such as suicidal ideation…

Computation and Language · Computer Science 2026-04-09 Adrian Arnaiz-Rodriguez , Miguel Baidal , Erik Derner , Jenn Layton Annable , Mark Ball , Mark Ince , Elvira Perez Vallejos , Nuria Oliver

Generative large language models (LLMs) have revolutionized natural language processing with their transformative and emergent capabilities. However, recent evidence indicates that LLMs can produce harmful content that violates social…

Cryptography and Security · Computer Science 2025-04-08 Xiaohan Yuan , Jinfeng Li , Dongxia Wang , Yuefeng Chen , Xiaofeng Mao , Longtao Huang , Jialuo Chen , Hui Xue , Xiaoxia Liu , Wenhai Wang , Kui Ren , Jingyi Wang

The remarkable capabilities of Large Language Models (LLMs) make them increasingly compelling for adoption in real-world healthcare applications. However, the risks associated with using LLMs in medical applications have not been…

The automotive industry faces increasing challenges in ensuring both functional safety (FuSa) and cybersecurity for complex semiconductor devices. Traditional Failure Mode and Effects Analysis (FMEA) primarily addresses safety-related…

Cryptography and Security · Computer Science 2026-03-09 Antonino Armato , Marzana Khatun , Sebastian Fischer

The healthcare industry is currently experiencing an unprecedented wave of cybersecurity attacks, impacting millions of individuals. With the discovery of thousands of vulnerabilities each month, there is a pressing need to drive the…

Computation and Language · Computer Science 2024-07-23 Rikhiya Ghosh , Oladimeji Farri , Hans-Martin von Stockhausen , Martin Schmitt , George Marica Vasile

As Large Language Models (LLMs) and generative AI become more widespread, the content safety risks associated with their use also increase. We find a notable deficiency in high-quality content safety datasets and benchmarks that…

Machine Learning · Computer Science 2024-09-12 Shaona Ghosh , Prasoon Varshney , Erick Galinkin , Christopher Parisien

While Large Language Models (LLMs) have seen widespread applications across numerous fields, their limited interpretability poses concerns regarding their safe operations from multiple aspects, e.g., truthfulness, robustness, and fairness.…

Software Engineering · Computer Science 2024-04-15 Xuan Xie , Jiayang Song , Zhehua Zhou , Yuheng Huang , Da Song , Lei Ma

The proliferation of Large Language Models (LLMs) in medicine has enabled impressive capabilities, yet a critical gap remains in their ability to perform systematic, transparent, and verifiable reasoning, a cornerstone of clinical practice.…

Computation and Language · Computer Science 2025-08-04 Wenxuan Wang , Zizhan Ma , Meidan Ding , Shiyi Zheng , Shengyuan Liu , Jie Liu , Jiaming Ji , Wenting Chen , Xiang Li , Linlin Shen , Yixuan Yuan

The scarcity of high-quality annotated medical data, particularly in mental health, poses a significant bottleneck for training robust machine learning models. Privacy regulations restrict data sharing, making synthetic data generation a…