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Automating tissue segmentation and tumor detection in histopathology images of colorectal cancer (CRC) is an enabler for faster diagnostic pathology workflows. At the same time it is a challenging task due to low availability of public…

Image and Video Processing · Electrical Eng. & Systems 2023-04-07 Lydia A. Schoenpflug , Maxime W. Lafarge , Anja L. Frei , Viktor H. Koelzer

A reliable deep learning system should be able to accurately express its confidence with respect to its predictions, a quality known as calibration. One of the most effective ways to produce reliable confidence estimates with a pre-trained…

Machine Learning · Computer Science 2024-10-10 Thomas P. Zollo , Zhun Deng , Jake C. Snell , Toniann Pitassi , Richard Zemel

Most of the current state-of-the-art methods for tumor segmentation are based on machine learning models trained on manually segmented images. This type of training data is particularly costly, as manual delineation of tumors is not only…

Computer Vision and Pattern Recognition · Computer Science 2019-08-21 Pawel Mlynarski , Hervé Delingette , Antonio Criminisi , Nicholas Ayache

Accurate prognosis of a tumor can help doctors provide a proper course of treatment and, therefore, save the lives of many. Traditional machine learning algorithms have been eminently useful in crafting prognostic models in the last few…

Image and Video Processing · Electrical Eng. & Systems 2022-02-28 Numan Saeed , Roba Al Majzoub , Ikboljon Sobirov , Mohammad Yaqub

Deep neural network(DNN) based classifiers do extremely well in discriminating between observations, resulting in higher ROC AUC and accuracy metrics, but their outputs are often miscalibrated with respect to true event likelihoods.…

Machine Learning · Computer Science 2025-12-30 Dhruv Nigam

Head and neck tumors and metastatic lymph nodes are crucial for treatment planning and prognostic analysis. Accurate segmentation and quantitative analysis of these structures require pixel-level annotation, making automated segmentation…

Image and Video Processing · Electrical Eng. & Systems 2025-04-01 Litingyu Wang , Wenjun Liao , Shichuan Zhang , Guotai Wang

This paper investigates the post-hoc calibration of confidence for "exploratory" machine learning classification problems. The difficulty in these problems stems from the continuing desire to push the boundaries of which categories have…

Although deep neural networks yield high classification accuracy given sufficient training data, their predictions are typically overconfident or under-confident, i.e., the prediction confidences cannot truly reflect the accuracy. Post-hoc…

Computer Vision and Pattern Recognition · Computer Science 2024-02-15 Jiexin Wang , Jiahao Chen , Bing Su

High degrees of disagreement among annotators can exist for ambiguous objects, e.g. in medical images, underscoring the challenges of establishing ground truth annotations in object detection tasks. Despite this, all existing object…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Zhi Qin Tan , Owen Addison , Yunpeng Li

Despite the remarkable performance of supervised medical image segmentation models, relying on a large amount of labeled data is impractical in real-world situations. Semi-supervised learning approaches aim to alleviate this challenge using…

Computer Vision and Pattern Recognition · Computer Science 2025-09-17 Yunyao Lu , Yihang Wu , Ahmad Chaddad , Tareef Daqqaq , Reem Kateb

Phyllodes tumors (PTs) are rare fibroepithelial breast lesions that are difficult to classify preoperatively due to their radiological similarity to benign fibroadenomas. This often leads to unnecessary surgical excisions. To address this,…

Computer Vision and Pattern Recognition · Computer Science 2025-09-26 Farhan Fuad Abir , Abigail Elliott Daly , Kyle Anderman , Tolga Ozmen , Laura J. Brattain

Medical images are generally labeled by multiple experts before the final ground-truth labels are determined. Consensus or disagreement among experts regarding individual images reflects the gradeability and difficulty levels of the image.…

Computer Vision and Pattern Recognition · Computer Science 2020-07-30 Shuang Yu , Hong-Yu Zhou , Kai Ma , Cheng Bian , Chunyan Chu , Hanruo Liu , Yefeng Zheng

Deep neural networks have demonstrated remarkable performance across numerous learning tasks but often suffer from miscalibration, resulting in unreliable probability outputs. This has inspired many recent works on mitigating…

Machine Learning · Computer Science 2025-09-23 Wenjian Huang , Guiping Cao , Jiahao Xia , Jingkun Chen , Hao Wang , Jianguo Zhang

Current deep visual local feature detectors do not model the spatial uncertainty of detected features, producing suboptimal results in downstream applications. In this work, we propose two post-hoc covariance estimates that can be plugged…

Computer Vision and Pattern Recognition · Computer Science 2023-08-16 Javier Tirado-Garín , Frederik Warburg , Javier Civera

Recent advances in deep learning have greatly facilitated the automated segmentation of ultrasound images, which is essential for nodule morphological analysis. Nevertheless, most existing methods depend on extensive and precise annotations…

Computer Vision and Pattern Recognition · Computer Science 2024-04-24 Xingyue Zhao , Zhongyu Li , Xiangde Luo , Peiqi Li , Peng Huang , Jianwei Zhu , Yang Liu , Jihua Zhu , Meng Yang , Shi Chang , Jun Dong

It is often observed that the probabilistic predictions given by a machine learning model can disagree with averaged actual outcomes on specific subsets of data, which is also known as the issue of miscalibration. It is responsible for the…

Machine Learning · Computer Science 2020-01-28 Feiyang Pan , Xiang Ao , Pingzhong Tang , Min Lu , Dapeng Liu , Lei Xiao , Qing He

Post-hoc calibration is usually evaluated as a function of logits or softmax confidence alone, even as routing-augmented architectures increasingly accompany predictions with sample-specific internal routing traces and pair them with claims…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Wenhao Liang , Lin Yue , Wei Emma Zhang , Miao Xu , Mingyu Guo , Olaf Maennel , Weitong Chen

Automatic abnormality detection in abdominal CT scans can help doctors improve the accuracy and efficiency in diagnosis. In this paper we aim at detecting pancreatic ductal adenocarcinoma (PDAC), the most common pancreatic cancer. Taking…

Computer Vision and Pattern Recognition · Computer Science 2019-08-28 Fengze Liu , Yuyin Zhou , Elliot Fishman , Alan Yuille

Despite the superior performance of Deep Learning (DL) on numerous segmentation tasks, the DL-based approaches are notoriously overconfident about their prediction with highly polarized label probability. This is often not desirable for…

Image and Video Processing · Electrical Eng. & Systems 2021-12-14 Sungmin Hong , Anna K. Bonkhoff , Andrew Hoopes , Martin Bretzner , Markus D. Schirmer , Anne-Katrin Giese , Adrian V. Dalca , Polina Golland , Natalia S. Rost

Clinical cystoscopy, the current standard for bladder cancer diagnosis, suffers from significant reliance on physician expertise, leading to variability and subjectivity in diagnostic outcomes. There is an urgent need for objective,…

Image and Video Processing · Electrical Eng. & Systems 2025-08-22 Jinliang Yu , Mingduo Xie , Yue Wang , Tianfan Fu , Xianglai Xu , Jiajun Wang