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Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive forms of pancreatic cancer and is often diagnosed at an advanced stage due to subtle early imaging signs. To enable earlier detection and improve clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-12-16 Han Liu , Riqiang Gao , Eileen Krieg , Sasa Grbic

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer in which the tumor-vascular involvement greatly affects the resectability and, thus, overall survival of patients. However, current prognostic prediction methods fail to…

Image and Video Processing · Electrical Eng. & Systems 2023-09-14 Hexin Dong , Jiawen Yao , Yuxing Tang , Mingze Yuan , Yingda Xia , Jian Zhou , Hong Lu , Jingren Zhou , Bin Dong , Le Lu , Li Zhang , Zaiyi Liu , Yu Shi , Ling Zhang

Multi-rater annotations commonly occur when medical images are independently annotated by multiple experts (raters). In this paper, we tackle two challenges arisen in multi-rater annotations for medical image segmentation (called ambiguous…

Computer Vision and Pattern Recognition · Computer Science 2024-08-26 Jinhong Wang , Yi Cheng , Jintai Chen , Hongxia Xu , Danny Chen , Jian Wu

Calibrating deep learning models to yield uncertainty-aware predictions is crucial as deep neural networks get increasingly deployed in safety-critical applications. While existing post-hoc calibration methods achieve impressive results on…

Machine Learning · Computer Science 2023-07-06 Christian Tomani , Futa Waseda , Yuesong Shen , Daniel Cremers

Pancreatic cancers have one of the worst prognoses compared to other cancers, as they are diagnosed when cancer has progressed towards its latter stages. The current manual histological grading for diagnosing pancreatic adenocarcinomas is…

Image and Video Processing · Electrical Eng. & Systems 2022-06-20 Biraja Ghoshal , Bhargab Ghoshal , Allan Tucker

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, and early detection remains a major clinical challenge due to the absence of specific symptoms and reliable biomarkers. In this work, we propose a new multimodal…

Probability calibration for deep models is highly desirable in safety-critical applications such as medical imaging. It makes output probabilities of deep networks interpretable, by aligning prediction probability with the actual accuracy…

Computer Vision and Pattern Recognition · Computer Science 2022-09-16 Cheng Ouyang , Shuo Wang , Chen Chen , Zeju Li , Wenjia Bai , Bernhard Kainz , Daniel Rueckert

Deep neural networks often produce miscalibrated probability estimates, leading to overconfident predictions. A common approach for calibration is fitting a post-hoc calibration map on unseen validation data that transforms predicted…

Machine Learning · Computer Science 2025-07-10 Yunrui Zhang , Gustavo Batista , Salil S. Kanhere

We introduce the notion of heterogeneous calibration that applies a post-hoc model-agnostic transformation to model outputs for improving AUC performance on binary classification tasks. We consider overconfident models, whose performance is…

Machine Learning · Statistics 2022-02-11 David Durfee , Aman Gupta , Kinjal Basu

Accurate brain tumor segmentation from MRI scans is critical for diagnosis and treatment planning. Despite the strong performance of recent deep learning approaches, two fundamental limitations remain: (1) the lack of reliable uncertainty…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Bahram Mohammadi , Yanqiu Wu , Vu Minh Hieu Phan , Sam White , Minh-Son To , Jian Yang , Michael Sheng , Yang Song , Yuankai Qi

We propose an evaluation framework for class probability estimates (CPEs) in the presence of label uncertainty, which is commonly observed as diagnosis disagreement between experts in the medical domain. We also formalize evaluation metrics…

Machine Learning · Statistics 2021-03-23 Takahiro Mimori , Keiko Sasada , Hirotaka Matsui , Issei Sato

Molecular subtyping of PDAC into basal-like and classical has established prognostic and predictive value. However, its use in clinical practice is limited by cost, turnaround time, and tissue requirements, thereby restricting its…

Annotation cost is a bottleneck for collecting massive data in mammography, especially for training deep neural networks. In this paper, we study the use of heterogeneous levels of annotation granularity to improve predictive performances.…

Image and Video Processing · Electrical Eng. & Systems 2019-09-13 Thi-Lam-Thuy Le , Nicolas Thome , Sylvain Bernard , Vincent Bismuth , Fanny Patoureaux

Despite recent medical advancements, breast cancer remains one of the most prevalent and deadly diseases among women. Although machine learning-based Computer-Aided Diagnosis (CAD) systems have shown potential to assist radiologists in…

Image and Video Processing · Electrical Eng. & Systems 2023-08-29 Mohammad Karimzadeh , Aleksandar Vakanski , Min Xian , Boyu Zhang

Accurate brain tumor segmentation from MRI is limited by expensive annotations and data heterogeneity across scanners and sites. We propose a semi-supervised teacher-student framework that combines an uncertainty-aware pseudo-labeling…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Jiaming Liu , Cheng Ding , Daoqiang Zhang

Pancreatic cancer will soon be the second leading cause of cancer-related death in Western society. Imaging techniques such as CT, MRI and ultrasound typically help providing the initial diagnosis, but histopathological assessment is still…

Image and Video Processing · Electrical Eng. & Systems 2022-01-26 Pierpaolo Vendittelli , Esther M. M. Smeets , Geert Litjens

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer, with most cases diagnosed at stage IV and a five-year overall survival rate below 5%. Early detection and prognosis modeling are crucial for improving patient outcomes…

Machine Learning · Computer Science 2025-04-02 David Le , Ramon Correa-Medero , Amara Tariq , Bhavik Patel , Motoyo Yano , Imon Banerjee

This paper studies the problem of post-hoc calibration of machine learning classifiers. We introduce the following desiderata for uncertainty calibration: (a) accuracy-preserving, (b) data-efficient, and (c) high expressive power. We show…

Machine Learning · Computer Science 2020-07-01 Jize Zhang , Bhavya Kailkhura , T. Yong-Jin Han

Annotation ambiguity due to inherent data uncertainties such as blurred boundaries in medical scans and different observer expertise and preferences has become a major obstacle for training deep-learning based medical image segmentation…

Computer Vision and Pattern Recognition · Computer Science 2024-03-21 Yicheng Wu , Xiangde Luo , Zhe Xu , Xiaoqing Guo , Lie Ju , Zongyuan Ge , Wenjun Liao , Jianfei Cai

Radiomics and deep learning both offer powerful tools for quantitative medical imaging, but most existing fusion approaches only leverage global radiomic features and overlook the complementary value of spatially resolved radiomic…

Image and Video Processing · Electrical Eng. & Systems 2026-02-23 Zengtian Deng , Yimeng He , Yu Shi , Lixia Wang , Touseef Ahmad Qureshi , Xiuzhen Huang , Debiao Li