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Related papers: From Brain Models to Executable Digital Twins: Exe…

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In exploring the simulation of human rhythmic perception and synchronization capabilities, this study introduces a computational model inspired by the physical and biological processes underlying rhythm processing. Utilizing a reservoir…

Neurons and Cognition · Quantitative Biology 2025-03-28 Zhongju Yuan , Wannes Van Ransbeeck , Geraint Wiggins , Dick Botteldooren

The challenge of translating vast, multimodal biological data into predictive and mechanistic understanding of cellular function is a central theme in modern biology. Virtual cells, or digital cellular twins, have emerged as a critical…

Quantitative Methods · Quantitative Biology 2025-09-24 Saurabh Bhardwaj , Gaurav Kumar , Haochen Yang , Shaurya Bhardwaj , Qun Wang , Minjie Shen , Yizhi Wang , Cristabelle Madona De Souza

Digital twins, used to represent physical systems, have been lauded as tools for understanding reality. Complex system behavior is typically captured in domain-specific models crafted by subject experts. Contemporary methods for employing…

Systems and Control · Electrical Eng. & Systems 2025-09-30 John Morris , Douglas L. Van Bossuyt , Edward Louis , Gregory Mocko , John Wagner

The ability to train ever-larger neural networks brings artificial intelligence to the forefront of scientific and technical discoveries. However, their exponentially increasing size creates a proportionally greater demand for energy and…

Clinical trials are indispensable for medical research and the development of new treatments. However, clinical trials often involve thousands of participants and can span several years to complete, with a high probability of failure during…

Machine Learning · Computer Science 2024-07-02 Yue Wang , Tianfan Fu , Yinlong Xu , Zihan Ma , Hongxia Xu , Yingzhou Lu , Bang Du , Honghao Gao , Jian Wu

While the concept of a digital twin to support maritime operations is gaining attention for predictive maintenance, real-time monitoring, control, and overall process optimization, clarity on its implementation is missing in the literature.…

Systems and Control · Electrical Eng. & Systems 2023-01-24 Federico Zocco , Hsueh-Cheng Wang , Mien Van

Single-arm trials are an important study design for evaluating drug efficacy and safety without enrolling patients into a control arm. Although they do not provide the gold-standard evidence of randomized controlled trials, they are…

Applications · Statistics 2026-05-14 Daniele Bertolini , Franklin Fuller , Aaron M. Smith , Jonathan R. Walsh , Run Zhuang

Deliberative democracy depends on carefully designed institutional frameworks, such as participant selection, facilitation methods, and decision-making mechanisms, that shape how deliberation performs. However, identifying optimal…

Multiagent Systems · Computer Science 2025-06-12 Claudio Novelli , Javier Argota Sánchez-Vaquerizo , Dirk Helbing , Antonino Rotolo , Luciano Floridi

Digital Twins technology is revolutionizing decision-making in scientific research by integrating models and simulations with real-time data. Unlike traditional Structural Health Monitoring methods, which rely on computationally intensive…

Computer Vision and Pattern Recognition · Computer Science 2024-10-10 Mehrdad Shafiei Dizaji

In the way towards Industry 4.0, the complexity of the industrial systems increases due to the presence of multiple agents, Cyber-Physical Systems, distributed sensing, and big data introducing unknown dynamics that affect the production…

Signal Processing · Electrical Eng. & Systems 2020-07-09 Jairo Viola , YangQuan Chen

With rapid digitization and digitalization, drawing a fine line between the digital and the physical world has become nearly impossible. It has become essential more than ever to integrate all spheres of life into a single Digital Thread to…

A review of scientific papers has shown that digital twins are very common for modeling the states of physical objects. It is relevant to consider the creation of a digital twin of an enterprise to obtain various assessments in management,…

Optimization and Control · Mathematics 2024-12-13 Sergey Masaev , Andrey Minkin , Evgeniy Troyak , Andrey Khrulkevich

Digital twins are virtual systems designed to predict how a real-world process will evolve in response to interventions. This modelling paradigm holds substantial promise in many applications, but rigorous procedures for assessing their…

Methodology · Statistics 2023-11-03 Rob Cornish , Muhammad Faaiz Taufiq , Arnaud Doucet , Chris Holmes

The digital twin has emerged as a technology to predict the undesirables, and ensure desired performance of complex systems. Although digital twins have got attention in the manufacturing research spectrum, yet their industrial application…

Systems and Control · Electrical Eng. & Systems 2021-04-08 Ali Ahmad Malik

A patient's digital twin is a computational model that describes the evolution of their health over time. Digital twins have the potential to revolutionize medicine by enabling individual-level computer simulations of human health, which…

The fundamental, powerful process of computation in the brain has been widely misunderstood. The paper [1] associates the general failure to build intelligent thinking machines with current reductionist principles of temporal coding and…

Neural and Evolutionary Computing · Computer Science 2012-10-09 Dorian Aur

Emerging from NASA's spacecraft simulations in the 1960s, digital twin technology has advanced through industrial adoption to spark a healthcare transformation. A digital twin is a dynamic, data-driven virtual counterpart of a physical…

Artificial Intelligence · Computer Science 2025-11-27 Yunqi Zhang , Kuangyu Shi , Biao Li

Precise and timely simulation of a structure's dynamic behavior is crucial for evaluating its performance and assessing its health status. Traditional numerical methods are often limited by high computational costs and low efficiency, while…

Computational Engineering, Finance, and Science · Computer Science 2025-06-24 Jun Zhang , Tong Zhang , Ying Wang

Medical digital twins are computational models of human biology relevant to a given medical condition, which can be tailored to an individual patient, thereby predicting the course of disease and individualized treatments, an important goal…

In this paper, a computationally efficient data-driven hybrid automaton model is proposed to capture unknown complex dynamical system behaviors using multiple neural networks. The sampled data of the system is divided by valid partitions…

Systems and Control · Electrical Eng. & Systems 2023-04-28 Yejiang Yang , Zihao Mo , Weiming Xiang
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