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Related papers: PepBenchmark: A Standardized Benchmark for Peptide…

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As large language models (LLMs) continue to advance, the need for up-to-date and well-organized benchmarks becomes increasingly critical. However, many existing datasets are scattered, difficult to manage, and make it challenging to perform…

Machine Learning · Computer Science 2025-06-03 Eunsu Kim , Haneul Yoo , Guijin Son , Hitesh Patel , Amit Agarwal , Alice Oh

The primary way to establish and compare competencies in foundation and generative AI models has shifted from peer-reviewed literature to press releases and company blog posts, where model builders highlight results on selected benchmarks.…

Artificial Intelligence · Computer Science 2026-05-15 Stefan Baack , Christo Buschek , Maty Bohacek

Structure-based drug design has seen significant advancements with the integration of artificial intelligence (AI), particularly in the generation of hit and lead compounds. However, most AI-driven approaches neglect the importance of…

Machine Learning · Computer Science 2025-11-10 Xinheng He , Yijia Zhang , Haowei Lin , Xingang Peng , Xiangzhe Kong , Mingyu Li , Jianzhu Ma

Deep learning (DL) and machine learning (ML) models have shown promise in drug response prediction (DRP), yet their ability to generalize across datasets remains an open question, raising concerns about their real-world applicability. Due…

Large language models (LLMs) show significant potential in healthcare, prompting numerous benchmarks to evaluate their capabilities. However, concerns persist regarding the reliability of these benchmarks, which often lack clinical…

Computation and Language · Computer Science 2026-04-30 Wenting Chen , Guo Yu , Yiu-Fai Cheung , Meidan Ding , Jie Liu , Zizhan Ma , Wenxuan Wang , Linlin Shen

Recent advances in probabilistic modelling have led to a large number of simulation-based inference algorithms which do not require numerical evaluation of likelihoods. However, a public benchmark with appropriate performance metrics for…

Machine Learning · Statistics 2021-04-12 Jan-Matthis Lueckmann , Jan Boelts , David S. Greenberg , Pedro J. Gonçalves , Jakob H. Macke

The vast collection of machine learning records available on the web presents a significant opportunity for meta-learning, where past experiments are leveraged to improve performance. Two crucial meta-learning tasks are pipeline performance…

Predicting whether a molecule can cross the blood-brain barrier (BBB) is a key step in early-stage neuro-pharmaceutical design, directly influencing the efficiency and success rate of drug development. Traditional methods based on…

Quantitative Methods · Quantitative Biology 2026-03-16 Zihan Yang , Yuchen Xiao

Data preparation is a central and time-consuming stage in data analysis workflows. Traditionally, commercial tools have relied on graphical user interfaces (GUIs) to simplify data preparation, allowing users to define transformations…

Databases · Computer Science 2026-05-12 Jingzhe Xu , Rui Wang , Jiannan Wang , Guoliang Li

Learning multimodal representations involves integrating information from multiple heterogeneous sources of data. It is a challenging yet crucial area with numerous real-world applications in multimedia, affective computing, robotics,…

The rise of big data systems has created a need for benchmarks to measure and compare the capabilities of these systems. Big data benchmarks present unique scalability challenges. The supercomputing community has wrestled with these…

Performance · Computer Science 2016-12-13 Patrick Dreher , Chansup Byun , Chris Hill , Vijay Gadepally , Bradley Kuszmaul , Jeremy Kepner

Understanding and leveraging the 3D structures of proteins is central to a variety of biological and drug discovery tasks. While deep learning has been applied successfully for structure-based protein function prediction tasks, current…

Machine Learning · Computer Science 2024-04-03 Rong Han , Wenbing Huang , Lingxiao Luo , Xinyan Han , Jiaming Shen , Zhiqiang Zhang , Jun Zhou , Ting Chen

We introduce the Autoregressive PDE Emulator Benchmark (APEBench), a comprehensive benchmark suite to evaluate autoregressive neural emulators for solving partial differential equations. APEBench is based on JAX and provides a seamlessly…

Machine Learning · Computer Science 2024-11-04 Felix Koehler , Simon Niedermayr , Rüdiger Westermann , Nils Thuerey

The rapid advancement of large language models (LLMs) has accelerated their integration into clinical decision support, particularly in prescription review. To enable systematic and fine-grained evaluation, we developed RxBench, a…

Computation and Language · Computer Science 2025-12-03 Yan Yang , Mouxiao Bian , Peiling Li , Bingjian Wen , Ruiyao Chen , Kangkun Mao , Xiaojun Ye , Tianbin Li , Pengcheng Chen , Bing Han , Jie Xu , Kaifeng Qiu , Junyan Wu

Often the development of novel functional peptides is not amenable to high throughput or purely computational screening methods. Peptides must be synthesized one at a time in a process that does not generate large amounts of data. One way…

Biomolecules · Quantitative Biology 2020-12-14 Rainier Barrett , Andrew D. White

CTBench is introduced as a benchmark to assess language models (LMs) in aiding clinical study design. Given study-specific metadata, CTBench evaluates AI models' ability to determine the baseline features of a clinical trial (CT), which…

Computation and Language · Computer Science 2024-06-27 Nafis Neehal , Bowen Wang , Shayom Debopadhaya , Soham Dan , Keerthiram Murugesan , Vibha Anand , Kristin P. Bennett

One of the key requirements for incorporating machine learning into the drug discovery process is complete reproducibility and traceability of the model building and evaluation process. With this in mind, we have developed an end-to-end…

This paper surveys benchmarking principles, machine learning devices including GPUs, FPGAs, and ASICs, and deep learning software frameworks. It also reviews these technologies with respect to benchmarking from the perspectives of a…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-02-19 Wei Dai , Daniel Berleant

Liquid chromatography with tandem mass spectrometry (LC-MS/MS) based proteomics is a well-established research field with major applications such as identification of disease biomarkers, drug discovery, drug design and development. In…

Quantitative Methods · Quantitative Biology 2018-01-08 Fatema Tuz Zohora , Ngoc Hieu Tran , Xianglilan Zhang , Lei Xin , Baozhen Shan , Ming Li

Benchmarking has long served as a foundational practice in machine learning and, increasingly, in modern AI systems such as large language models, where shared tasks, metrics, and leaderboards offer a common basis for measuring progress and…

Artificial Intelligence · Computer Science 2026-02-16 Philip Waggoner
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