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This paper presents SimMIM, a simple framework for masked image modeling. We simplify recently proposed related approaches without special designs such as block-wise masking and tokenization via discrete VAE or clustering. To study what let…

Computer Vision and Pattern Recognition · Computer Science 2022-04-19 Zhenda Xie , Zheng Zhang , Yue Cao , Yutong Lin , Jianmin Bao , Zhuliang Yao , Qi Dai , Han Hu

This paper explores improvements to the masked image modeling (MIM) paradigm. The MIM paradigm enables the model to learn the main object features of the image by masking the input image and predicting the masked part by the unmasked part.…

Computer Vision and Pattern Recognition · Computer Science 2022-05-24 Jiawei Mao , Xuesong Yin , Yuanqi Chang , Honggu Zhou

Medical vision-language pre-training shows great potential in learning representative features from massive paired radiographs and reports. However, in computed tomography (CT) scans, the distribution of lesions which contain intricate…

Computer Vision and Pattern Recognition · Computer Science 2025-09-11 Rongsheng Wang , Fenghe Tang , Qingsong Yao , Rui Yan , Xu Zhang , Zhen Huang , Haoran Lai , Zhiyang He , Xiaodong Tao , Zihang Jiang , Shaohua Kevin Zhou

Hematoxylin and eosin (H&E)-stained slides are central to cancer diagnosis and monitoring, visualizing tissue architecture and cellular morphology. However, H&E lacks the molecular specificity needed to distinguish cell states and…

Image and Video Processing · Electrical Eng. & Systems 2026-04-14 Tushar Kataria , Beatrice Knudsen , Shireen Y. Elhabian

The Segment Anything Model (SAM) has garnered significant attention for its versatile segmentation abilities and intuitive prompt-based interface. However, its application in medical imaging presents challenges, requiring either substantial…

Computer Vision and Pattern Recognition · Computer Science 2024-03-28 Zhiheng Cheng , Qingyue Wei , Hongru Zhu , Yan Wang , Liangqiong Qu , Wei Shao , Yuyin Zhou

Medical image segmentation is a fundamental task for medical image analysis and surgical planning. In recent years, UNet-based networks have prevailed in the field of medical image segmentation. However, convolution-neural networks (CNNs)…

Computer Vision and Pattern Recognition · Computer Science 2023-06-06 Xin You , Junjun He , Jie Yang , Yun Gu

Intelligent metasurfaces may be harnessed for realizing efficient holographic multiple-input and multiple-output (MIMO) systems, at a low hardware-cost and high energy-efficiency. As part of this family, we propose a hybrid beamforming…

Information Theory · Computer Science 2025-02-18 Qingchao Li , Mohammed El-Hajjar , Chao Xu , Jiancheng An , Chau Yuen , Lajos Hanzo

Sparse autoencoders (SAEs) emerged as a promising tool for mechanistic interpretability of transformer-based foundation models. Very recently, SAEs were also adopted for the visual domain, enabling the discovery of visual concepts and their…

Computer Vision and Pattern Recognition · Computer Science 2025-07-17 Muhammed Furkan Dasdelen , Hyesu Lim , Michele Buck , Katharina S. Götze , Carsten Marr , Steffen Schneider

Histology imaging is an important tool in medical diagnosis and research, enabling the examination of tissue structure and composition at the microscopic level. Understanding the underlying molecular mechanisms of tissue architecture is…

Computer Vision and Pattern Recognition · Computer Science 2023-10-30 Ronald Xie , Kuan Pang , Sai W. Chung , Catia T. Perciani , Sonya A. MacParland , Bo Wang , Gary D. Bader

With the development of multimodality and large language models, the deep learning-based technique for medical image captioning holds the potential to offer valuable diagnostic recommendations. However, current generic text and image…

Computer Vision and Pattern Recognition · Computer Science 2024-01-02 Zhenyu Zhang , Benlu Wang , Weijie Liang , Yizhi Li , Xuechen Guo , Guanhong Wang , Shiyan Li , Gaoang Wang

We introduce Smooth InfoMax (SIM), a self-supervised representation learning method that incorporates interpretability constraints into the latent representations at different depths of the network. Based on $\beta$-VAEs, SIM's architecture…

Machine Learning · Computer Science 2025-06-24 Fabian Denoodt , Bart de Boer , José Oramas

Compared to hematoxylin-eosin (H&E) staining, immunohistochemistry (IHC) not only maintains the structural features of tissue samples, but also provides high-resolution protein localization, which is essential for aiding in pathology…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Yuhang Kang , Ziyu Su , Tianyang Wang , Zaibo Li , Wei Chen , Muhammad Khalid Khan Niazi

Multiple instance learning (MIL) is the dominant framework for whole-slide image analysis in computational pathology, typically combining a frozen patch encoder, a projection layer, and a slide-level aggregator. While encoders and…

Quantitative Methods · Quantitative Biology 2026-05-19 Yucheng Xing , Pei Liu , Jingying Ma , Ruping Hong , Jiangdong Qiu , Tianyu Liu , Kai He , Ling Huang , Mengling Feng

With the proposal of the Segment Anything Model (SAM), fine-tuning SAM for medical image segmentation (MIS) has become popular. However, due to the large size of the SAM model and the significant domain gap between natural and medical…

Computer Vision and Pattern Recognition · Computer Science 2024-10-01 Jinfeng Wang , Sifan Song , Xinkun Wang , Yiyi Wang , Yiyi Miao , Jionglong Su , S. Kevin Zhou

Fine-tuning foundation models for Earth Observation is computationally expensive, with high training time and memory demands for both training and deployment. Parameter-efficient methods reduce training cost but retain full inference…

Computer Vision and Pattern Recognition · Computer Science 2026-03-23 Víctor Barreiro , Johannes Jakubik , Francisco Argüello , Dora B. Heras

Structured illumination microscopy (SIM) provides images of fluorescent objects at an enhanced resolution greater than that of conventional epifluorescence wide-field microscopy. Initially demonstrated in 1999 to enhance the lateral…

Optics · Physics 2022-03-09 James D. Manton

Structured illumination microscopy (SIM) has attained high spatiotemporal delineation of subcellular architecture, yet offers limited insight into chemical composition. We develop Chem-SIM, a structured-illumination fluorescence detected…

The blind structured illumination microscopy (SIM) strategy proposed in (Mudry et al., 1992) is fully re-founded in this paper, unveiling the central role of the sparsity of the illumination patterns in the mechanism that drives…

Data Analysis, Statistics and Probability · Physics 2017-04-26 Simon Labouesse , Awoke Negash , Jérôme Idier , Sébastien Bourguignon , Thomas Mangeat , Penghuan Liu , Anne Sentenac , Marc Allain

One-shot medical image segmentation (MIS) is crucial for medical analysis due to the burden of medical experts on manual annotation. The recent emergence of the segment anything model (SAM) has demonstrated remarkable adaptation in MIS but…

Image and Video Processing · Electrical Eng. & Systems 2025-04-30 Jia Wang , Yunan Mei , Jiarui Liu , Xin Fan

Deep learning has been effective for histology image analysis in digital pathology. However, many current deep learning approaches require large, strongly- or weakly-labeled images and regions of interest, which can be time-consuming and…

Computer Vision and Pattern Recognition · Computer Science 2023-04-07 Joseph DiPalma , Lorenzo Torresani , Saeed Hassanpour