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Domain specific large language models are increasingly used to support patient education, triage, and clinical decision making in ophthalmology, making rigorous evaluation essential to ensure safety and accuracy. This study evaluated four…

The prevalence and impact of toxic discussions online have made content moderation crucial.Automated systems can play a vital role in identifying toxicity, and reducing the reliance on human moderation.Nevertheless, identifying toxic…

Artificial Intelligence · Computer Science 2023-11-02 Senjuti Dutta , Sid Mittal , Sherol Chen , Deepak Ramachandran , Ravi Rajakumar , Ian Kivlichan , Sunny Mak , Alena Butryna , Praveen Paritosh

We hypothesize that large language models (LLMs) based on the transformer architecture can enable automated detection of clinical phenotype terms, including terms not documented in the HPO. In this study, we developed two types of models:…

Quantitative Methods · Quantitative Biology 2023-11-10 Jingye Yang , Cong Liu , Wendy Deng , Da Wu , Chunhua Weng , Yunyun Zhou , Kai Wang

Large language models (LLMs) have demonstrated impressive performance across various domains. However, for clinical diagnosis, higher expectations are required for LLM's reliability and sensitivity: thinking like physicians and remaining…

Computation and Language · Computer Science 2025-04-21 Chenwei Yan , Xiangling Fu , Yuxuan Xiong , Tianyi Wang , Siu Cheung Hui , Ji Wu , Xien Liu

Artificially intelligent (AI) co-scientists must be able to sift through research literature cost-efficiently while applying nuanced scientific reasoning. We evaluate Small Language Models (SLMs, <= 8B parameters) for classifying medical…

Computational Engineering, Finance, and Science · Computer Science 2025-12-09 Muhammed Muaaz Dawood , Mohammad Zaid Moonsamy , Kaela Kokkas , Hairong Wang , Robert F. Breiman , Richard Klein , Emmanuel K. Sekyi , Bruce A. Bassett

Large language models (LLMs) have shown promise in safety-critical applications such as healthcare, yet the ability to quantify performance has lagged. An example of this challenge is in evaluating a summary of the patient's medical record.…

Computation and Language · Computer Science 2024-11-13 Elliot Schumacher , Daniel Rosenthal , Dhruv Naik , Varun Nair , Luladay Price , Geoffrey Tso , Anitha Kannan

Advances in large language models (LLMs) have empowered a variety of applications. However, there is still a significant gap in research when it comes to understanding and enhancing the capabilities of LLMs in the field of mental health. In…

Computation and Language · Computer Science 2024-01-30 Xuhai Xu , Bingsheng Yao , Yuanzhe Dong , Saadia Gabriel , Hong Yu , James Hendler , Marzyeh Ghassemi , Anind K. Dey , Dakuo Wang

Large language models (LLMs) have attracted significant attention for potential applications in digital health, while their application in mental health is subject to ongoing debate. This systematic review aims to evaluate the usage of LLMs…

Computers and Society · Computer Science 2024-08-14 Zhijun Guo , Alvina Lai , Johan Hilge Thygesen , Joseph Farrington , Thomas Keen , Kezhi Li

Large Language models (LLMs), such as ChatGPT, have gained popularity in recent years with the advancement of Natural Language Processing (NLP), with use cases spanning many disciplines and daily lives as well. LLMs inherit explicit and…

Computation and Language · Computer Science 2025-12-01 Fatima Kazi

Protected health information (PHI) de-identification is critical for enabling the safe reuse of clinical notes, yet evaluating and comparing PHI de-identification models typically depends on costly, small-scale expert annotations. We…

Artificial Intelligence · Computer Science 2025-11-19 Guanchen Wu , Zuhui Chen , Yuzhang Xie , Carl Yang

Large Language Models (LLMs) demonstrate remarkable versatility in various NLP tasks but encounter distinct challenges in biomedical due to the complexities of language and data scarcity. This paper investigates LLMs application in the…

Computation and Language · Computer Science 2024-07-12 Masoud Monajatipoor , Jiaxin Yang , Joel Stremmel , Melika Emami , Fazlolah Mohaghegh , Mozhdeh Rouhsedaghat , Kai-Wei Chang

Large language models (LLMs) excel at clinical information extraction but their computational demands limit practical deployment. Knowledge distillation--the process of transferring knowledge from larger to smaller models--offers a…

Computation and Language · Computer Science 2025-01-03 Karthik S. Vedula , Annika Gupta , Akshay Swaminathan , Ivan Lopez , Suhana Bedi , Nigam H. Shah

Difficult-to-treat depression (DTD) has been proposed as a broader and more clinically comprehensive perspective on a person's depressive disorder where despite treatment, they continue to experience significant burden. We sought to develop…

Computation and Language · Computer Science 2024-02-13 Isabelle Lorge , Dan W. Joyce , Niall Taylor , Alejo Nevado-Holgado , Andrea Cipriani , Andrey Kormilitzin

The emergence of large language models (LLMs), pre-trained on massive datasets, has demonstrated strong performance across a wide range of natural language processing (NLP) tasks, including text classification. While prior studies have…

Software Engineering · Computer Science 2025-11-25 Yasaman Abedini , Abbas Heydarnoori

This paper investigates hybrid intelligence and collaboration between researchers of sexism and Large Language Models (LLMs), with a four-component pipeline. First, nine sexism researchers answer questions about their knowledge of sexism…

Computation and Language · Computer Science 2025-04-23 Myrthe Reuver , Indira Sen , Matteo Melis , Gabriella Lapesa

This study evaluates how well large language models (LLMs) can classify ICD-10 codes from hospital discharge summaries, a critical but error-prone task in healthcare. Using 1,500 summaries from the MIMIC-IV dataset and focusing on the 10…

Computation and Language · Computer Science 2025-07-08 Akram Mustafa , Usman Naseem , Mostafa Rahimi Azghadi

Large language models (LLMs) are employed to simulate human-like responses in social surveys, yet it remains unclear if they develop biases like social desirability response (SDR) bias. To investigate this, GPT-4 was assigned personas from…

Artificial Intelligence · Computer Science 2024-10-22 Sanguk Lee , Kai-Qi Yang , Tai-Quan Peng , Ruth Heo , Hui Liu

Large Language Models (LLMs) inherit explicit and implicit biases from their training datasets. Identifying and mitigating biases in LLMs is crucial to ensure fair outputs, as they can perpetuate harmful stereotypes and misinformation. This…

Machine Learning · Computer Science 2025-11-19 Fatima Kazi , Alex Young , Yash Inani , Setareh Rafatirad

Hate speech detection is a socially sensitive and inherently subjective task, with judgments often varying based on personal traits. While prior work has examined how socio-demographic factors influence annotation, the impact of personality…

Computation and Language · Computer Science 2025-06-11 Shuzhou Yuan , Ercong Nie , Mario Tawfelis , Helmut Schmid , Hinrich Schütze , Michael Färber

Retaining persons living with HIV (PLWH) in medical care is paramount to preventing new transmissions of the virus and allowing PLWH to live normal and healthy lifespans. Maintaining regular appointments with an HIV provider and taking…