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The increasing availability of unstructured clinical narratives in electronic health records (EHRs) has created new opportunities for automated disease characterization, cohort identification, and clinical decision support. However,…

Computation and Language · Computer Science 2026-03-03 Fariba Afrin Irany , Sampson Akwafuo

Rapid integration of large language models (LLMs) in health care is sparking global discussion about their potential to revolutionize health care quality and accessibility. At a time when improving health care quality and access remains a…

Computers and Society · Computer Science 2025-04-01 Troy Zada , Natalie Tam , Francois Barnard , Marlize Van Sittert , Venkat Bhat , Sirisha Rambhatla

Detecting online sexual predatory behaviours and abusive language on social media platforms has become a critical area of research due to the growing concerns about online safety, especially for vulnerable populations such as children and…

Computation and Language · Computer Science 2023-08-29 Thanh Thi Nguyen , Campbell Wilson , Janis Dalins

The development of vision-language models (VLMs) for histo-pathology has shown promising new usages and zero-shot performances. However, current approaches, which decompose large slides into smaller patches, focus solely on inductive…

Computer Vision and Pattern Recognition · Computer Science 2024-09-04 Maxime Zanella , Fereshteh Shakeri , Yunshi Huang , Houda Bahig , Ismail Ben Ayed

Patients who are at clinical high risk (CHR) for schizophrenia need close monitoring of their symptoms to inform appropriate treatments. The Brief Psychiatric Rating Scale (BPRS) is a validated, commonly used research tool for measuring…

Computation and Language · Computer Science 2025-08-15 Andrew X. Chen , Guillermo Horga , Sean Escola

Matching patients to clinical trial options is critical for identifying novel treatments, especially in oncology. However, manual matching is labor-intensive and error-prone, leading to recruitment delays. Pipelines incorporating large…

Computation and Language · Computer Science 2025-09-25 Braxton A. Morrison , Madhumita Sushil , Jacob S. Young

Medical reports contain rich clinical information but are often unstructured and written in domain-specific language, posing challenges for information extraction. While proprietary large language models (LLMs) have shown promise in…

Computation and Language · Computer Science 2026-03-12 Luc Builtjes , Joeran Bosma , Mathias Prokop , Bram van Ginneken , Alessa Hering

Mitigating explicit and implicit biases in Large Language Models (LLMs) has become a critical focus in the field of natural language processing. However, many current methodologies evaluate scenarios in isolation, without considering the…

Computation and Language · Computer Science 2025-02-04 Robert Morabito , Sangmitra Madhusudan , Tyler McDonald , Ali Emami

Medical systems in general, and patient treatment decisions and outcomes in particular, are affected by bias based on gender and other demographic elements. As language models are increasingly applied to medicine, there is a growing…

Computation and Language · Computer Science 2021-03-11 Joshua R. Minot , Nicholas Cheney , Marc Maier , Danne C. Elbers , Christopher M. Danforth , Peter Sheridan Dodds

Large Language Models (LLMs) have remarkable capabilities across NLP tasks. However, their performance in multilingual contexts, especially within the mental health domain, has not been thoroughly explored. In this paper, we evaluate…

Computation and Language · Computer Science 2026-02-03 Nishat Raihan , Sadiya Sayara Chowdhury Puspo , Ana-Maria Bucur , Stevie Chancellor , Marcos Zampieri

Social and behavioral determinants of health (SDOH) play a significant role in shaping health outcomes, and extracting these determinants from clinical notes is a first step to help healthcare providers systematically identify opportunities…

Computation and Language · Computer Science 2023-10-31 Adam D. Lelkes , Eric Loreaux , Tal Schuster , Ming-Jun Chen , Alvin Rajkomar

Current datasets for unwanted social bias auditing are limited to studying protected demographic features such as race and gender. In this work, we introduce a comprehensive benchmark that is meant to capture the amplification of social…

Computation and Language · Computer Science 2023-12-29 Manish Nagireddy , Lamogha Chiazor , Moninder Singh , Ioana Baldini

LGBTQ+ community face disproportionate mental health challenges, including higher rates of depression, anxiety, and suicidal ideation. Research has shown that LGBTQ+ people have been using large language model-based chatbots, such as…

Human-Computer Interaction · Computer Science 2024-05-09 Yinru Long , Zilin Ma , Yiyang Mei , Zhaoyuan Su

Social determinants of health (SDOH) extraction from clinical text is critical for downstream healthcare analytics. Although large language models (LLMs) have shown promise, they may rely on superficial cues leading to spurious predictions.…

Computation and Language · Computer Science 2025-06-03 Fardin Ahsan Sakib , Ziwei Zhu , Karen Trister Grace , Meliha Yetisgen , Ozlem Uzuner

Stigma toward people who use substances (PWUS) is a leading barrier to seeking treatment.Further, those in treatment are more likely to drop out if they experience higher levels of stigmatization. While related concepts of hate speech and…

This study evaluates the performance of large language models (LLMs) and the HINT model in predicting clinical trial outcomes, focusing on metrics including Balanced Accuracy, Matthews Correlation Coefficient (MCC), Recall, and Specificity.…

Machine Learning · Computer Science 2025-03-19 Shuyi Jin , Lu Chen , Hongru Ding , Meijie Wang , Lun Yu

Tumor documentation in Germany is largely done manually, requiring reading patient records and entering data into structured databases. Large language models (LLMs) could potentially enhance this process by improving efficiency and…

Computation and Language · Computer Science 2025-08-08 Stefan Lenz , Arsenij Ustjanzew , Marco Jeray , Meike Ressing , Torsten Panholzer

This paper introduces a novel paradigm for depression detection and treatment using advanced Large Language Models (LLMs): Generative Pre-trained Transformer 4 (GPT-4), Llama 2 chat, and Gemini. These LLMs are fine-tuned with specialized…

Computation and Language · Computer Science 2024-02-09 Aryan Agrawal

Individuals who identify as sexual and gender minorities, including lesbian, gay, bisexual, transgender, queer, and others (LGBTQ+) are more likely to experience poorer health than their heterosexual and cisgender counterparts. One primary…

Computation and Language · Computer Science 2024-11-21 S. Chapagain , Y. Zhao , T. K. Rohleen , S. M. Hamdi , S. F. Boubrahimi , R. E. Flinn , E. M. Lund , D. Klooster , J. R. Scheer , C. J. Cascalheira

Both medical care and observational studies in oncology require a thorough understanding of a patient's disease progression and treatment history, often elaborately documented in clinical notes. Despite their vital role, no current oncology…

Computation and Language · Computer Science 2024-03-18 Madhumita Sushil , Vanessa E. Kennedy , Divneet Mandair , Brenda Y. Miao , Travis Zack , Atul J. Butte
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