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Covariate adjustment is an approach to improve the precision of trial analyses by adjusting for baseline variables that are prognostic of the primary endpoint. Motivated by the SEARCH Universal HIV Test-and-Treat Trial (2013-2017), we tell…

Methodology · Statistics 2025-12-16 Laura B. Balzer , Mark J. van der Laan , Maya L. Petersen

To discover intrinsic inter-class transition probabilities underlying data, learning with noise transition has become an important approach for robust deep learning on corrupted labels. Prior methods attempt to achieve such transition…

Machine Learning · Computer Science 2020-06-15 Jun Shu , Qian Zhao , Zongben Xu , Deyu Meng

Unmeasured confounders are a major source of bias in regression-based effect estimation and causal inference. In this paper, we advocate a new profiled transfer learning framework, ProTrans, to address confounding effects in the target…

Methodology · Statistics 2025-09-04 Ziyuan Chen , Yifan Jiang , Jingyuan Liu , Fang Yao

The proliferation of data has sparked significant interest in leveraging findings from one study to estimate treatment effects in a different target population without direct outcome observations. However, the transfer learning process is…

Methodology · Statistics 2025-05-15 Seok-Jin Kim , Hongjie Liu , Molei Liu , Kaizheng Wang

We present methods for causally interpretable meta-analyses that combine information from multiple randomized trials to estimate potential (counterfactual) outcome means and average treatment effects in a target population. We consider…

A common concern when a policymaker draws causal inferences from and makes decisions based on observational data is that the measured covariates are insufficiently rich to account for all sources of confounding, i.e., the standard no…

Methodology · Statistics 2023-10-25 Tao Shen , Yifan Cui

Random-effects meta-analysis summarizes heterogeneous trials by estimating an average effect over the observed evidence base, which may not represent the clinically relevant target population. In cardiovascular medicine, treatment effects…

Methodology · Statistics 2026-04-22 Ibrahim Halil Tanboga

The focus in machine learning has branched beyond training classifiers on a single task to investigating how previously acquired knowledge in a source domain can be leveraged to facilitate learning in a related target domain, known as…

Machine Learning · Computer Science 2018-10-30 Tyler R. Scott , Karl Ridgeway , Michael C. Mozer

Meta-learning methods perform well on new within-distribution tasks but often fail when adapting to out-of-distribution target tasks, where transfer from source tasks can induce negative transfer. We propose a causally-aware Bayesian…

Machine Learning · Computer Science 2026-02-24 Lotta Mäkinen , Jorge Loría , Samuel Kaski

Randomized controlled trials are the standard method for estimating causal effects, ensuring sufficient statistical power and confidence through adequate sample sizes. However, achieving such sample sizes is often challenging. This study…

Methodology · Statistics 2025-03-28 Keisuke Hanada , Masahiro Kojima

Treatment policy estimands are frequently favored by regulators, as they assess the effect of treatment assignment regardless of post-randomization events. Despite best efforts, missing data due to study discontinuation cannot be fully…

Methodology · Statistics 2026-05-13 Ajmal Oodally , Craig Wang , Zheng Li , Tim Morris , Tobias Mütze , Arunava Chakravartty

In recent years, real-world external controls have grown in popularity as a tool to empower randomized placebo-controlled trials, particularly in rare diseases or cases where balanced randomization is unethical or impractical. However, as…

Methodology · Statistics 2024-11-14 Chenyin Gao , Shu Yang , Mingyang Shan , Wenyu Ye , Ilya Lipkovich , Douglas Faries

In recent years, supervised machine learning models have demonstrated tremendous success in a variety of application domains. Despite the promising results, these successful models are data hungry and their performance relies heavily on the…

Machine Learning · Computer Science 2018-12-05 Azin Asgarian , Parinaz Sobhani , Ji Chao Zhang , Madalin Mihailescu , Ariel Sibilia , Ahmed Bilal Ashraf , Babak Taati

Predicting drug response in patients from preclinical data remains a major challenge in precision oncology due to the substantial biological gap between in vitro cell lines and patient tumors. Rather than aiming to improve absolute in vitro…

Machine Learning · Computer Science 2026-03-18 Camille Jimenez Cortes , Philippe Lalanda , German Vega

In this work, we propose a Semi-supervised Triply Robust Inductive transFer LEarning (STRIFLE) approach, which integrates heterogeneous data from a label-rich source population and a label-scarce target population and utilizes a large…

Methodology · Statistics 2024-10-24 Tianxi Cai , Mengyan Li , Molei Liu

Transfer learning enhances prediction accuracy on a target distribution by leveraging data from a source distribution, demonstrating significant benefits in various applications. This paper introduces a novel dissimilarity measure that…

Machine Learning · Statistics 2024-12-12 Mitsuhiro Fujikawa , Yohei Akimoto , Jun Sakuma , Kazuto Fukuchi

Unobserved confounding prevents standard covariate adjustment from identifying causal response functions in observational studies. Proxy causal learning addresses this problem through bridge equations involving treatment- and…

Machine Learning · Computer Science 2026-05-12 Bariscan Bozkurt , Alexandre Galashov , Dimitri Meunier , Zikai Shen , Arthur Gretton , Houssam Zenati

A high-quality experimental dataset is often much smaller than a corresponding observational dataset. When this holds with possibly biased measurements of the outcome of interest in the latter, we propose an estimation and inference…

Methodology · Statistics 2026-05-19 Harrison H Li

Transfer learning can significantly improve the sample efficiency of neural networks, by exploiting the relatedness between a data-scarce target task and a data-abundant source task. Despite years of successful applications, transfer…

Machine Learning · Computer Science 2023-06-06 Federica Gerace , Luca Saglietti , Stefano Sarao Mannelli , Andrew Saxe , Lenka Zdeborová

We study target-population quantile treatment effects when a source study may have unmeasured treatment confounding and may not transport to a target population after conditioning on observed covariates. The observed data consist of a…

Methodology · Statistics 2026-05-12 Pengyun Wang