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Facing a global epidemic of new infectious diseases such as COVID-19, non-pharmaceutical interventions (NPIs), which reduce transmission rates without medical actions, are being implemented around the world to mitigate spreads. One of the…

Populations and Evolution · Quantitative Biology 2021-03-04 Naoya Fujiwara , Tomokatsu Onaga , Takayuki Wada , Shouhei Takeuchi , Junji Seto , Tomoki Nakaya , Kazuyuki Aihara

Emerging infectious diseases and climate change are two of the major challenges in 21st century. Although over the past decades, highly-resolved mathematical models have contributed in understanding dynamics of infectious diseases and are…

Populations and Evolution · Quantitative Biology 2025-10-13 Julia Bicker , René Schmieding , Michael Meyer-Hermann , Martin J. Kühn

Parameter calibration is a significant challenge in agent-based modelling and simulation (ABMS). An agent-based model's (ABM) complexity grows as the number of parameters required to be calibrated increases. This parameter expansion leads…

Machine Learning · Computer Science 2021-08-20 Rylan Perumal , Terence L van Zyl

A model-based signal processing framework is proposed for pandemic trend forecasting and control, by using non-pharmaceutical interventions (NPI) at regional and country levels worldwide. The control objective is to prescribe quantifiable…

Optimization and Control · Mathematics 2021-11-23 Reza Sameni

Epidemiological models can not only be used to forecast the course of a pandemic like COVID-19, but also to propose and design non-pharmaceutical interventions such as school and work closing. In general, the design of optimal policies…

Optimization and Control · Mathematics 2023-04-06 Jan-Hendrik Niemann , Samuel Uram , Sarah Wolf , Nataša Djurdjevac Conrad , Martin Weiser

To mitigate the impact of the pandemic, several measures include lockdowns, rapid vaccination programs, school closures, and economic stimulus. These interventions can have positive or unintended negative consequences. Current research to…

Machine Learning · Computer Science 2025-08-11 Gaurav Deshkar , Jayanta Kshirsagar , Harshal Hayatnagarkar , Janani Venugopalan

The rapid emergence of open-source, locally hosted intelligent agents marks a critical inflection point in human-computer interaction. Systems such as OpenClaw demonstrate that Large Language Model (LLM)-based agents can autonomously…

Artificial Intelligence · Computer Science 2026-03-13 Rui Liu , Tao Zhe , Dongjie Wang , Zijun Yao , Kunpeng Liu , Yanjie Fu , Huan Liu , Jian Pei

Agent-based simulators (ABS) are a popular epidemiological modelling tool to study the impact of various non-pharmaceutical interventions in managing an epidemic in a city (or a region). They provide the flexibility to accurately model a…

Physics and Society · Physics 2025-10-13 Daksh Mittal , Sandeep Juneja

This paper considers the problem of designing non-pharmaceutical intervention (NPI) strategies, such as masking and social distancing, to slow the spread of a viral epidemic. We formulate the problem of jointly minimizing the infection…

Systems and Control · Electrical Eng. & Systems 2024-12-02 Shiyu Cheng , Luyao Niu , Bhaskar Ramasubramanian , Andrew Clark , Radha Poovendran

Agent-based models (ABMs) are widely used to study infectious disease dynamics, but their calibration is often computationally intensive, limiting their applicability in time-sensitive public health settings. We propose DeepIMC (Deep…

Machine Learning · Computer Science 2026-04-03 Sima Najafzadehkhoei , George Vega Yon , Derek S. Meyer , Bernardo Modenesi

Global health surveillance is currently facing a challenge of Knowledge Gaps. While general-purpose AI has proliferated, it remains fundamentally unsuited for the high-stakes epidemiological domain due to chronic hallucinations and an…

Multiagent Systems · Computer Science 2026-01-06 Aniket Wattamwar , Sampson Akwafuo

Several models have been developed to predict how the COVID-19 pandemic spreads, and how it could be contained with non-pharmaceutical interventions (NPIs) such as social distancing restrictions and school and business closures. This paper…

Neural and Evolutionary Computing · Computer Science 2020-08-04 Risto Miikkulainen , Olivier Francon , Elliot Meyerson , Xin Qiu , Elisa Canzani , Babak Hodjat

Globally, the outbreaks of infectious diseases have exerted an extremely profound and severe influence on health security and the economy. During the critical phases of epidemics, devising effective intervention measures poses a significant…

Machine Learning · Computer Science 2025-05-08 Baida Zhang , Yakai Chen , Huichun Li , Zhenghu Zu

LLM-based agents are increasingly deployed for complex tasks requiring planning, tool use, and interaction with external services. Their reliance on untrusted external content exposes them to indirect prompt injection (IPI), in which…

Machine Learning · Computer Science 2026-05-26 Zixuan Chen , Jiaxiang Chen , Li Luo , Ke Xu , Xiaoxiang Huang , Tanfeng Sun , Xinghao Jiang

Mechanistic simulators are an indispensable tool for epidemiology to explore the behavior of complex, dynamic infections under varying conditions and navigate uncertain environments. Agent-based models (ABMs) are an increasingly popular…

This study investigates the influence of different types of non-pharmaceutical interventions (NPIs) on epidemic progression using SIR compartmental models. We analyze the optimization of two distinct targets: the final epidemic size and the…

Populations and Evolution · Quantitative Biology 2026-04-10 Eric Rozán , Marcelo N Kuperman , Sebastián Bouzat

Optimal control theory in epidemiology has been used to establish the most effective intervention strategies for managing and mitigating the spread of infectious diseases while considering constraints and costs. Using Pontryagin's Maximum…

Physics and Society · Physics 2025-08-08 Sandra Montes-Olivas , Adam J. Kucharski , Michael B. Gravenor , Simon D. W. Frost

AI agents are increasingly deployed as quasi-autonomous systems for specialized tasks, yet their potential as computational models of decision-making remains underexplored. We develop a generative AI agent to study repetitive policy…

Multiagent Systems · Computer Science 2026-01-09 Goshi Aoki , Navid Ghaffarzadegan

A crucial aspect of managing a public health crisis is to effectively balance prevention and mitigation strategies, while taking their socio-economic impact into account. In particular, determining the influence of different…

With the advent of the computational technologies (Graphics Processing Units - GPUs) and Machine Learning, the research domain of crowd simulation for crisis management has flourished. Along with the new techniques and methodologies that…

Multiagent Systems · Computer Science 2020-09-10 George Sidiropoulos , Chairi Kiourt , Lefteris Moussiades
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