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While multimodal survival prediction models are increasingly more accurate, their complexity often reduces interpretability, limiting insight into how different data sources influence predictions. To address this, we introduce DIMAFx, an…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Aniek Eijpe , Soufyan Lakbir , Melis Erdal Cesur , Sara P. Oliveira , Angelos Chatzimparmpas , Sanne Abeln , Wilson Silva

Medical multimodal learning faces significant challenges with missing modalities prevalent in clinical practice. Existing approaches assume equal contribution of modality and random missing patterns, neglecting inherent uncertainty in…

Machine Learning · Computer Science 2026-01-30 Linxiao Gong , Yang Liu , Lianlong Sun , Yulai Bi , Jing Liu , Xiaoguang Zhu

Multimodal sentiment analysis has been studied under the assumption that all modalities are available. However, such a strong assumption does not always hold in practice, and most of multimodal fusion models may fail when partial modalities…

Machine Learning · Computer Science 2022-05-02 Jiandian Zeng , Tianyi Liu , Jiantao Zhou

With the rapid advances in high-throughput sequencing technologies, the focus of survival analysis has shifted from examining clinical indicators to incorporating genomic profiles with pathological images. However, existing methods either…

Image and Video Processing · Electrical Eng. & Systems 2023-09-25 Fengtao Zhou , Hao Chen

Multimodal learning is susceptible to modality missing, which poses a major obstacle for its practical applications and, thus, invigorates increasing research interest. In this paper, we investigate two challenging problems: 1) when…

Machine Learning · Computer Science 2023-12-19 Jun Sun , Xinxin Zhang , Shoukang Han , Yu-ping Ruan , Taihao Li

Multimodal deep learning (MDL) has emerged as a transformative approach in computational pathology. By integrating complementary information from multiple data sources, MDL models have demonstrated superior predictive performance across…

Quantitative Methods · Quantitative Biology 2025-11-17 Seth Alain Chang , Muhammad Mueez Amjad , Noorul Wahab , Ethar Alzaid , Nasir Rajpoot , Adam Shephard

Accurate and reliable brain tumor segmentation, particularly when dealing with missing modalities, remains a critical challenge in medical image analysis. Previous studies have not fully resolved the challenges of tumor boundary…

Computer Vision and Pattern Recognition · Computer Science 2025-07-31 Shenghao Zhu , Yifei Chen , Weihong Chen , Yuanhan Wang , Chang Liu , Shuo Jiang , Feiwei Qin , Changmiao Wang

The accurate segmentation of brain tumors from multi-modal MRI is critical for clinical diagnosis and treatment planning. While integrating complementary information from various MRI sequences is a common practice, the frequent absence of…

Computer Vision and Pattern Recognition · Computer Science 2026-03-06 Dongqing Xie , Yonghuang Wu , Zisheng Ai , Jun Min , Zhencun Jiang , Shaojin Geng , Lei Wang

Multimodal networks have demonstrated remarkable performance improvements over their unimodal counterparts. Existing multimodal networks are designed in a multi-branch fashion that, due to the reliance on fusion strategies, exhibit…

We investigate the problem of multimodal search of target modality, where the task involves enhancing a query in a specific target modality by integrating information from auxiliary modalities. The goal is to retrieve relevant objects whose…

Databases · Computer Science 2023-12-12 Mengzhao Wang , Xiangyu Ke , Xiaoliang Xu , Lu Chen , Yunjun Gao , Pinpin Huang , Runkai Zhu

In real-world clinical settings, magnetic resonance imaging (MRI) frequently suffers from missing modalities due to equipment variability or patient cooperation issues, which can significantly affect model performance. To address this…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Zhejia Zhang , Junjie Wang , Le Zhang

Clinical notes contain rich patient information, such as diagnoses or medications, making them valuable for patient representation learning. Recent advances in large language models have further improved the ability to extract meaningful…

Machine Learning · Computer Science 2025-09-23 Zihan Liang , Ziwen Pan , Ruoxuan Xiong

We introduce Transfusion, a recipe for training a multi-modal model over discrete and continuous data. Transfusion combines the language modeling loss function (next token prediction) with diffusion to train a single transformer over…

Artificial Intelligence · Computer Science 2024-08-21 Chunting Zhou , Lili Yu , Arun Babu , Kushal Tirumala , Michihiro Yasunaga , Leonid Shamis , Jacob Kahn , Xuezhe Ma , Luke Zettlemoyer , Omer Levy

The integration of multimodal data including pathology images and gene profiles is widely applied in precise survival prediction. Despite recent advances in multimodal survival models, collecting complete modalities for multimodal fusion…

Machine Learning · Computer Science 2025-03-25 Yingxue Xu , Fengtao Zhou , Chenyu Zhao , Yihui Wang , Can Yang , Hao Chen

Incomplete multi-modal image segmentation is a fundamental task in medical imaging to refine deployment efficiency when only partial modalities are available. However, the common practice that complete-modality data is visible during model…

Computer Vision and Pattern Recognition · Computer Science 2024-07-23 Junjie Shi , Caozhi Shang , Zhaobin Sun , Li Yu , Xin Yang , Zengqiang Yan

Early identification of intensive care patients at risk of in-hospital mortality enables timely intervention and efficient resource allocation. Despite high predictive performance, existing machine learning approaches lack transparency and…

Machine Learning · Computer Science 2025-11-21 Alexander Bakumenko , Janine Hoelscher , Hudson Smith

To improve the prediction of cancer survival using whole-slide images and transcriptomics data, it is crucial to capture both modality-shared and modality-specific information. However, multimodal frameworks often entangle these…

Computer Vision and Pattern Recognition · Computer Science 2025-06-30 Aniek Eijpe , Soufyan Lakbir , Melis Erdal Cesur , Sara P. Oliveira , Sanne Abeln , Wilson Silva

Magnetic Resonance Imaging (MRI) is a widely used imaging technique to assess brain tumor. Accurately segmenting brain tumor from MR images is the key to clinical diagnostics and treatment planning. In addition, multi-modal MR images can…

Image and Video Processing · Electrical Eng. & Systems 2021-04-21 Tongxue Zhou , Stéphane Canu , Pierre Vera , Su Ruan

Combining multiple modalities carrying complementary information through multimodal learning (MML) has shown considerable benefits for diagnosing multiple pathologies. However, the robustness of multimodal models to missing modalities is…

Machine Learning · Computer Science 2024-07-31 Hava Chaptoukaev , Vincenzo Marcianó , Francesco Galati , Maria A. Zuluaga

While pathology foundation models have transformed cancer image analysis, they often lack integration with molecular data at single-cell resolution, limiting their utility for precision oncology. Here, we present PAST, a pan-cancer…

Quantitative Methods · Quantitative Biology 2025-07-10 Changchun Yang , Haoyang Li , Yushuai Wu , Yilan Zhang , Yifeng Jiao , Yu Zhang , Rihan Huang , Yuan Cheng , Yuan Qi , Xin Guo , Xin Gao
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