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Retrieval-Augmented Generation (RAG) offers a cost-effective approach to injecting real-time knowledge into large language models (LLMs). Nevertheless, constructing and validating high-quality knowledge repositories require considerable…

Computation and Language · Computer Science 2024-05-28 Xun Liang , Simin Niu , Zhiyu li , Sensen Zhang , Shichao Song , Hanyu Wang , Jiawei Yang , Feiyu Xiong , Bo Tang , Chenyang Xi

Retrieval-Augmented Generation (RAG) systems enhance large language models (LLMs) by integrating external knowledge sources, enabling more accurate and contextually relevant responses tailored to user needs. However, existing RAG systems…

Information Retrieval · Computer Science 2025-04-29 Zirui Guo , Lianghao Xia , Yanhua Yu , Tu Ao , Chao Huang

Retrieval-Augmented Generation (RAG) enhances the reasoning ability of Large Language Models (LLMs) by dynamically integrating external knowledge, thereby mitigating hallucinations and strengthening contextual grounding for structured data…

Artificial Intelligence · Computer Science 2026-02-24 Sen Zhao , Lincheng Zhou , Yue Chen , Ding Zou

Retrieval-augmented generation (RAG) is key to enhancing large language models (LLMs) to systematically access richer factual knowledge. Yet, using RAG brings intrinsic challenges, as LLMs must deal with potentially conflicting knowledge,…

Computation and Language · Computer Science 2025-04-08 Leonardo Ranaldi , Federico Ranaldi , Fabio Massimo Zanzotto , Barry Haddow , Alexandra Birch

Graph-based Retrieval-Augmented Generation (RAG) has proven effective in integrating external knowledge into large language models (LLMs), improving their factual accuracy, adaptability, interpretability, and trustworthiness. A number of…

Information Retrieval · Computer Science 2026-04-28 Yingli Zhou , Yaodong Su , Youran Sun , Shu Wang , Taotao Wang , Runyuan He , Yongwei Zhang , Sicong Liang , Xilin Liu , Yuchi Ma , Yixiang Fang

Retrieval-Augmented Generation (RAG) represents a major advancement in natural language processing (NLP), combining large language models (LLMs) with information retrieval systems to enhance factual grounding, accuracy, and contextual…

Computation and Language · Computer Science 2025-07-28 Agada Joseph Oche , Ademola Glory Folashade , Tirthankar Ghosal , Arpan Biswas

The advent of Large Language Models (LLMs) has revolutionized natural language processing. However, these models face challenges in retrieving precise information from vast datasets. Retrieval-Augmented Generation (RAG) was developed to…

Information Retrieval · Computer Science 2025-03-04 Yuxin Yang , Haoyang Wu , Tao Wang , Jia Yang , Hao Ma , Guojie Luo

Retrieval-Augmented Generation (RAG) has been shown to enhance the factual accuracy of Large Language Models (LLMs), but existing methods often suffer from limited reasoning capabilities in effectively using the retrieved evidence,…

Computation and Language · Computer Science 2024-10-03 Shayekh Bin Islam , Md Asib Rahman , K S M Tozammel Hossain , Enamul Hoque , Shafiq Joty , Md Rizwan Parvez

Retrieval-Augmented Generation (RAG) has gained significant attention in recent years for its potential to enhance natural language understanding and generation by combining large-scale retrieval systems with generative models. RAG…

Computation and Language · Computer Science 2025-03-18 Mingyue Cheng , Yucong Luo , Jie Ouyang , Qi Liu , Huijie Liu , Li Li , Shuo Yu , Bohou Zhang , Jiawei Cao , Jie Ma , Daoyu Wang , Enhong Chen

Retrieval-Augmented Generation (RAG) systems have emerged as a promising solution to enhance large language models (LLMs) by integrating external knowledge retrieval with generative capabilities. While significant advancements have been…

Human-Computer Interaction · Computer Science 2025-08-11 Sizhe Cheng , Jiaping Li , Huanchen Wang , Yuxin Ma

In knowledge-intensive tasks, especially in high-stakes domains like medicine and law, it is critical not only to retrieve relevant information but also to provide causal reasoning and explainability. Large language models (LLMs) have…

Artificial Intelligence · Computer Science 2025-03-18 Hang Luo , Jian Zhang , Chujun Li

Graph-based retrieval-augmented generation (GraphRAG) exploits structured knowledge to support knowledge-intensive reasoning. However, most existing methods treat graphs as intermediate artifacts, and the few subgraph-based retrieval…

Information Retrieval · Computer Science 2026-03-10 Haonan Yuan , Qingyun Sun , Junhua Shi , Mingjun Liu , Jiaqi Yuan , Ziwei Zhang , Xingcheng Fu , Jianxin Li

Drug discovery (DD) has tremendously contributed to maintaining and improving public health. Hypothesizing that inhibiting protein misfolding can slow disease progression, researchers focus on target identification (Target ID) to find…

Quantitative Methods · Quantitative Biology 2025-01-29 Ziwen Li , Xiang 'Anthony' Chen , Youngseung Jeon

Graphs are a powerful tool for representing and analyzing unstructured, non-Euclidean data ubiquitous in the healthcare domain. Two prominent examples are molecule property prediction and brain connectome analysis. Importantly, recent works…

Machine Learning · Computer Science 2022-04-04 Kamilia Mullakaeva , Luca Cosmo , Anees Kazi , Seyed-Ahmad Ahmadi , Nassir Navab , Michael M. Bronstein

Biomedical ontologies, which comprehensively define concepts and relations for biomedical entities, are crucial for structuring and formalizing domain-specific information representations. Biomedical code mapping identifies similarity or…

Information Retrieval · Computer Science 2025-02-27 Hui Feng , Yuntzu Yin , Emiliano Reynares , Jay Nanavati

Large Language Models (LLMs) have achieved impressive performance across a wide range of applications. However, they often suffer from hallucinations in knowledge-intensive domains due to their reliance on static pretraining corpora. To…

Information Retrieval · Computer Science 2026-02-10 Lihui Liu , Jiayuan Ding , Subhabrata Mukherjee , Carl J. Yang

Large language models (LLMs) often struggle with knowledge-intensive tasks due to hallucinations and outdated parametric knowledge. While Retrieval-Augmented Generation (RAG) addresses this by integrating external corpora, its effectiveness…

Computation and Language · Computer Science 2026-02-04 Su Dong , Qinggang Zhang , Yilin Xiao , Shengyuan Chen , Chuang Zhou , Xiao Huang

Ensuring factual accuracy while maintaining the creative capabilities of Large Language Model Agents (LMAs) poses significant challenges in the development of intelligent agent systems. LMAs face prevalent issues such as information…

Artificial Intelligence · Computer Science 2024-05-21 Diego Sanmartin

Retrieval-Augmented Large Language Models (LLMs), which integrate external knowledge, have shown remarkable performance in medical domains, including clinical diagnosis. However, existing RAG methods often struggle to tailor retrieval…

Computation and Language · Computer Science 2025-10-16 Jiawei He , Mingyi Jia , Zhihao Jia , Junwen Duan , Yan Song , Jianxin Wang

We investigate molecular mechanisms of resistant or sensitive response of cancer drug combination therapies in an inductive and interpretable manner. Though deep learning algorithms are widely used in the drug synergy prediction problem, it…

Machine Learning · Computer Science 2021-05-18 Zehao Dong , Heming Zhang , Yixin Chen , Fuhai Li