Related papers: The FLASH enigma
We propose a multi-scale approach to understand the physics related to ion-beam cancer therapy. It allows the calculation of the probability of DNA damage as a result of irradiation of tissues with energetic ions, up to 430 MeV/u. This…
Research on ultra-high dose rate (UHDR) radiation therapy has indicated its potential to spare normal tissue while maintaining equivalent tumor control compared to conventional treatments. First clinical trials are underway. The randomized…
The single-pulse spectrum of self-amplified spontaneous emission (SASE) free electron lasers (FELs) is characterized by random fluctuations in frequency. The typical spectrum bandwidth for a hard x-ray FEL is in the range of 10-20 eV and is…
When confronted with an undesired cell population, such as bacterial infections or tumors, we seek the most effective treatment, designed to eliminate the population as rapidly as possible. A common practice is to monitor the cells…
In the Coulomb explosion acceleration regime, an ion bunch with a narrow energy range exhibits a thin shell shape with a certain diameter. The ion cloud has a layered structure of these ion bunches with different energies. The divergences…
The effective use of swift ion beams in cancer treatment (known as hadrontherapy) as well as an appropriate protection in manned space missions rely on the accurate understanding of energy delivery to cells damaging their genetic…
The conventional picture of the light amplification by stimulated emission of radiation (laser) is broken under the ultrastrong interaction between the electromagnetic fields and matter, and distinct dynamics of the electric field and of…
Observational aspects of solar flares relevant to the acceleration process of electrons and protons are reviewed and it is shown that most of these observations can be explained by the interaction with flare plasma of a power law energy…
Random fiber laser (RFL) is a complex physical system that arises from the distributed amplification and the intrinsic stochasticity of the fiber scattering. There has been widespread interest in analyzing the underlying lightwave kinetics…
Low grade gliomas (LGGs) are a group of primary brain tumors usually encountered in young patient populations. These tumors represent a difficult challenge because many patients survive a decade or more and may be at a higher risk for…
Since the analogy between laser oscillation and second-order phase transition was indicated in the 1970s, dynamical fluctuations on lasing threshold inherent in critical phenomena have gained significant interest. Here, we numerically and…
Cancer therapy for deep-seated tumors requires precise irradiation of a small target deep within the patient while minimizing radiation exposure to surrounding tissues. This can be accomplished with a round beam sharply converging towards a…
It has been known for some time that rotating bars in galaxies slow due to dynamical friction against the halo. However, recent attempts to use this process to place constraints on the dark matter density in galaxies and possibly also to…
The time delayed cytotoxic T-lymphocyte response on the tumor growth has been developed on the basis of discrete approximation (2-dimensional map). The growth kinetic has been described by logistic law with growth rate being the bifurcation…
This study presents a mathematical model that captures the interactions among tumor cells, healthy cells, and immune cells in a tumor-bearing host, with a specific focus on breast cancer. Incorporating the concept of delay, the model…
Chemotherapy is a class of cancer treatment that uses drugs to kill cancer cells. A typical chemotherapeutic protocol consists of several drugs delivered in cycles of three weeks. We present mathematical analyses demonstrating the existence…
The effect of the laser linewidth on the resonance fluorescence spectrum of a two-level atom is revisited. The novel spectral features, such as hole-burning and dispersive profiles at line centre of the fluorescence spectrum are predicted…
Radiotherapy is part of the treatment of over 50% of cancer patients. Its efficacy is limited by the radiotoxicity to the healthy tissue. FLASH-RT is based on the biological effect that ultra-high dose rates (UHDR) and very short treatment…
Spectral broadening of ultrashort laser pulses is simultaneously described by either self-phase modulation (SPM) or four-wave mixing (FWM). The latter implies the instantaneous conservation of both the photon number and energy, while the…
In the end of the second decade of 20th century, Warburg showed how cancer cells present a fermentative respiration process, related to a metabolic injury. Here, we develop an analysis of the cell process based on its heat outflow, in order…