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Large Language Models (LLMs) are increasingly deployed in medicine. However, their utility in non-generative clinical prediction, often presumed inferior to specialized models, remains under-evaluated, leading to ongoing debate within the…

Imagine a world where clinical trials need far fewer patients to achieve the same statistical power, thanks to the knowledge encoded in large language models (LLMs). We present a novel framework for hierarchical Bayesian modeling of adverse…

Methodology · Statistics 2025-11-21 Shota Arai , David Selby , Andrew Vargo , Sebastian Vollmer

Machine learning (ML) has recently shown promising results in medical predictions using electronic health records (EHRs). However, since ML models typically have a limited capability in terms of input sizes, selecting specific medical…

Machine Learning · Computer Science 2024-07-23 Junu Kim , Chaeeun Shim , Bosco Seong Kyu Yang , Chami Im , Sung Yoon Lim , Han-Gil Jeong , Edward Choi

Medical question-answering (QA) systems can benefit from advances in large language models (LLMs), but directly applying LLMs to the clinical domain poses challenges such as maintaining factual accuracy and avoiding hallucinations. In this…

Computation and Language · Computer Science 2025-12-08 Tasnimul Hassan , Md Faisal Karim , Haziq Jeelani , Elham Behnam , Robert Green , Fayeq Jeelani Syed

The emergence of Large Language Models (LLMs) presents unprecedented opportunities to revolutionize medical contrastive vision-language pre-training. In this paper, we show how LLMs can facilitate large-scale supervised pre-training,…

Computer Vision and Pattern Recognition · Computer Science 2025-09-17 Yingtai Li , Haoran Lai , Xiaoqian Zhou , Shuai Ming , Wenxin Ma , Wei Wei , Shaohua Kevin Zhou

Pre-trained Language Models (PLMs) have achieved great success on Machine Reading Comprehension (MRC) over the past few years. Although the general language representation learned from large-scale corpora does benefit MRC, the poor support…

Computation and Language · Computer Science 2021-05-19 Fangkai Jiao , Yangyang Guo , Yilin Niu , Feng Ji , Feng-Lin Li , Liqiang Nie

Large Language Models (LLMs) have significantly advanced natural language processing with exceptional task generalization capabilities. Low-Rank Adaption (LoRA) offers a cost-effective fine-tuning solution, freezing the original model…

Machine Learning · Computer Science 2025-03-18 Jun Zhang , Jue Wang , Huan Li , Lidan Shou , Ke Chen , Yang You , Guiming Xie , Xuejian Gong , Kunlong Zhou

Memory management is vital for LLM agents to handle long-term interaction and personalization. Most research focuses on how to organize and use memory summary, but often overlooks the initial memory extraction stage. In this paper, we argue…

Computation and Language · Computer Science 2026-01-09 Chengyuan Yang , Zequn Sun , Wei Wei , Wei Hu

Recent works have revealed the great potential of speculative decoding in accelerating the autoregressive generation process of large language models. The success of these methods relies on the alignment between draft candidates and the…

Computation and Language · Computer Science 2025-09-15 Jikai Wang , Zhenxu Tian , Juntao Li , Qingrong Xia , Xinyu Duan , Zhefeng Wang , Baoxing Huai , Min Zhang

Large language models (LLMs) have saturated standard medical benchmarks that test factual recall, yet their ability to perform higher-order reasoning, such as synthesizing evidence from multiple sources, remains critically under-explored.…

Computation and Language · Computer Science 2026-05-12 Huy Hoang Ha , Benoit Favre , Francois Portet

Accurately diagnosing bearing faults is crucial for maintaining the efficient operation of rotating machinery. However, traditional diagnosis methods face challenges due to the diversification of application environments, including…

Signal Processing · Electrical Eng. & Systems 2024-11-06 Laifa Tao , Haifei Liu , Guoao Ning , Wenyan Cao , Bohao Huang , Chen Lu

Aligning large language models (LLMs) with human preferences becomes a key component to obtaining state-of-the-art performance, but it yields a huge cost to construct a large human-annotated preference dataset. To tackle this problem, we…

Machine Learning · Computer Science 2025-03-05 Dongyoung Kim , Kimin Lee , Jinwoo Shin , Jaehyung Kim

Radiation therapy of thoracic and abdominal tumors requires incorporating the respiratory motion into treatments. To precisely account for the patient respiratory motions and predict the respiratory signals, a generalized model for…

Medical Physics · Physics 2019-05-22 Hui Lin , Chengyu Shi , Brian Wang , Maria F. Chan , Xiaoli Tang , Wei Ji

Reinforcement learning (RL) agents often suffer from high sample complexity in sparse or delayed reward settings due to limited prior structure. Large language models (LLMs) can provide subgoal decompositions, plausible trajectories, and…

Machine Learning · Computer Science 2026-02-23 Narjes Nourzad , Carlee Joe-Wong

Large Language Models (LLMs) have revolutionized numerous domains, driving the rise of Language-Model-as-a-Service (LMaaS) platforms that process millions of queries daily. These platforms must minimize latency and meet Service Level…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-10-21 Zhihan Jiang , Yujie Huang , Guangba Yu , Junjie Huang , Jiazhen Gu , Michael R. Lyu

Effective data selection is essential for pretraining large language models (LLMs), enhancing efficiency and improving generalization to downstream tasks. However, existing approaches often require leveraging external pretrained models,…

Machine Learning · Computer Science 2026-02-04 Jie Hao , Rui Yu , Wei Zhang , Huixia Wang , Jie Xu , Mingrui Liu

Pre-trained language models (PLMs) show impressive performance in various downstream NLP tasks. However, pre-training large language models demands substantial memory and training compute. Furthermore, due to the substantial resources…

Computation and Language · Computer Science 2024-04-01 HyunJin Kim , Young Jin Kim , JinYeong Bak

Despite their widespread applications, Large Language Models (LLMs) often struggle to express uncertainty, posing a challenge for reliable deployment in high stakes and safety critical domains like clinical diagnostics. Existing standard…

Machine Learning · Computer Science 2025-09-25 Mridul Sharma , Adeetya Patel , Zaneta D' Souza , Samira Abbasgholizadeh Rahimi , Siva Reddy , Sreenath Madathil

Large Language Models (LLMs) face limitations due to the high demand on GPU memory and computational resources when handling long contexts. While sparsify the Key-Value (KV) cache of transformer model is a typical strategy to alleviate…

Machine Learning · Computer Science 2024-02-06 Yumeng Wang , Zhenyang Xiao

Long-term memory is a cornerstone of human intelligence. Enabling AI to process lifetime-scale information remains a long-standing pursuit in the field. Due to the constraints of full-attention architectures, the effective context length of…

Computation and Language · Computer Science 2026-04-14 Yu Chen , Runkai Chen , Sheng Yi , Xinda Zhao , Xiaohong Li , Jianjin Zhang , Jun Sun , Chuanrui Hu , Yunyun Han , Lidong Bing , Yafeng Deng , Tianqiao Chen