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Sequence alignment is a fundamental process in computational biology which identifies regions of similarity in biological sequences. With the exponential growth in the volume of data in bioinformatics databases, the time, processing power,…

Hardware Architecture · Computer Science 2025-07-31 Nasrin Akbari , Mehdi Modarressi , Alireza Khadem

For the past four decades, cost and features have driven CMOS scaling. Severe lithography and material limitations seen below the 20 nm node, however, are challenging the fundamental premise of affordable CMOS scaling. Just continuing to…

Emerging Technologies · Computer Science 2015-09-04 Kaushik Vaidyanathan

Bit-level sparsity methods skip ineffectual zero-bit operations and are typically applicable within bit-serial deep learning accelerators. This type of sparsity at the bit-level is especially interesting because it is both orthogonal and…

Machine Learning · Computer Science 2024-09-10 Yuzong Chen , Jian Meng , Jae-sun Seo , Mohamed S. Abdelfattah

The continuous technological development of electronic devices and the introduction of new materials leads to ever greater demands on the fabrication of semiconductor heterostructures and their characterization. This work focuses on…

Radar has become an essential sensor for autonomous navigation, especially in challenging environments where camera and LiDAR sensors fail. 4D single-chip millimeter-wave radar systems, in particular, have drawn increasing attention thanks…

Robotics · Computer Science 2025-03-18 Jingqi Jiang , Shida Xu , Kaicheng Zhang , Jiyuan Wei , Jingyang Wang , Sen Wang

Most previous 3D IC research focused on stacking traditional 2D silicon layers, so the interconnect reduction is limited to inter-block delays. In this paper, we propose techniques that enable efficient exploration of the 3D design space…

Hardware Architecture · Computer Science 2025-08-20 Yongxiang Liu , Yuchun Ma , Eren Kurshan , Glenn Reinman , Jason Cong

Cosmological simulations require the use of a multiple time-stepping scheme. Without such a scheme, cosmological simulations would be impossible due to their high level of dynamic range; over eleven orders of magnitude in density. Such a…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-07-05 Josh Borrow , Richard G. Bower , Peter W. Draper , Pedro Gonnet , Matthieu Schaller

Due to the very rapidly growing use of Artificial Neural Networks (ANNs) in real-world applications related to machine learning and Artificial Intelligence (AI), several hardware accelerator de-signs for ANNs have been proposed recently. In…

Hardware Architecture · Computer Science 2021-03-09 Supreeth Mysore Shivanandamurthy , Ishan. G. Thakkar , Sayed Ahmad Salehi

Architected materials achieve unique mechanical properties through precisely engineered microstructures that minimize material usage. However, a key challenge of low-density materials is balancing high stiffness with stable deformability up…

Materials Science · Physics 2024-09-20 Matheus I. N. Rosa , Konstantinos Karapiperis , Kaoutar Radi , Dennis M. Kochmann

Inspired by the challenge of scaling up existing silicon quantum hardware, we investigate compilation strategies for sparsely-connected 2d qubit arrangements and propose a spin-qubit architecture with minimal compilation overhead. Our…

Quantum Physics · Physics 2022-01-11 O. Crawford , J. R. Cruise , N. Mertig , M. F. Gonzalez-Zalba

Developing ultra-low-energy superconducting computing and fault-tolerant quantum computing will require scalable superconducting memory. While conventional superconducting logic-based memory cells have facilitated early demonstrations,…

Crystalline two-dimensional (2D) semiconductors often combine high elasticity and in-plane strength, making them ideal for strain-induced tuning of electronic characteristics, akin to strategies used in silicon electronics. However,…

Advances in hybrid bonding and packaging have driven growing interest in 3D DRAM-stacked accelerators with higher memory bandwidth and capacity. As LLMs scale to hundreds of billions or trillions of parameters, distributed inference across…

While GPUs dominate massively parallel computing through the single-instruction, multiple-thread (SIMT) programming model, their underlying single-instruction, multiple-data (SIMD) execution incurs substantial energy overhead from frequent…

Hardware Architecture · Computer Science 2026-05-08 Jiayi Wang , Ang Da Lu , Zhichen Zeng , Ang Li

3D die-stacked DRAM has emerged as a key technology for delivering high bandwidth and high density for applications such as high-performance computing, graphics, and machine learning. However, different applications place diverse and…

Hardware Architecture · Computer Science 2025-12-16 Victor Cai , Jennifer Zhou , Haebin Do , David Brooks , Gu-Yeon Wei

We report here an atomic resolution study of the structure and composition of the grain boundaries in polycrystalline Sr0.6K0.4Fe2As2 superconductor. A large fraction of grain boundaries contain amorphous layers larger than the coherence…

Memristor is a promising building block for the next generation nonvolatile random access memory and bio-inspired computing systems. Organizing memristors into high density crossbar arrays, although challenging, is critical to meet the…

Mesoscale and Nanoscale Physics · Physics 2018-11-16 Shuang Pi , Can Li , Hao Jiang , Weiwei Xia , Huolin Xin , J. Joshua Yang , Qiangfei Xia

Albeit being a prevalent architecture searching approach, differentiable architecture search (DARTS) is largely hindered by its substantial memory cost since the entire supernet resides in the memory. This is where the single-path DARTS…

Machine Learning · Computer Science 2023-08-04 Xiaoxing Wang , Xiangxiang Chu , Yuda Fan , Zhexi Zhang , Bo Zhang , Xiaokang Yang , Junchi Yan

In 3D printing, stiff fibers (e.g., carbon fiber) can reinforce thermoplastic polymers with limited stiffness. However, existing commercial digital manufacturing software only provides a few simple fiber layout algorithms, which solely use…

Computational Engineering, Finance, and Science · Computer Science 2023-10-31 Xingyuan Sun , Geoffrey Roeder , Tianju Xue , Ryan P. Adams , Szymon Rusinkiewicz

Power flow feasibility assessment is computationally challenging for unbalanced three-phase distribution networks. This paper develops a vectorized semidefinite program (SDP) based on the bus injection model (BIM) and reformulates its dual…

Optimization and Control · Mathematics 2026-05-26 Bohang Fang , Lijun Ding , Cong Chen