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Long Short-Term Memory (LSTM) neural network models have become the cornerstone for sequential data modeling in numerous applications, ranging from natural language processing to time series forecasting. Despite their success, the problem…

Machine Learning · Statistics 2026-05-26 Fahad Mostafa

Various tasks, such as summarization, multi-hop question answering, or coreference resolution, are naturally phrased over collections of real-world documents. Such tasks present a unique set of challenges, revolving around the lack of…

Computation and Language · Computer Science 2024-06-25 Gili Lior , Avi Caciularu , Arie Cattan , Shahar Levy , Ori Shapira , Gabriel Stanovsky

Existing large language models (LLMs) evaluations use fixed-difficulty benchmarks that cannot adapt as models improve, and rarely isolate specific cognitive processes. We introduce Working Memory Fidelity-Active Manipulation (WMF-AM), a…

Artificial Intelligence · Computer Science 2026-05-05 Dengzhe Hou , Lingyu Jiang , Deng Li , Zirui Li , Fangzhou Lin , Kazunori D Yamada

The ability to design molecules while preserving similarity to a target molecule and/or property is crucial for various applications in drug discovery, chemical design, and biology. We introduce in this paper an efficient training-free…

Machine Learning · Computer Science 2025-11-18 Jiri Navratil , Jarret Ross , Payel Das , Youssef Mroueh , Samuel C Hoffman , Vijil Chenthamarakshan , Brian Belgodere

State space models (SSMs) provide a flexible framework for modeling complex time series via a latent stochastic process. Inference for nonlinear, non-Gaussian SSMs is often tackled with particle methods that do not scale well to long time…

Machine Learning · Statistics 2023-07-18 Christopher Aicher , Srshti Putcha , Christopher Nemeth , Paul Fearnhead , Emily B. Fox

Multiple sclerosis is a disease that affects the brain and spinal cord, it can lead to severe disability and has no known cure. The majority of prior work in machine learning for multiple sclerosis has been centered around using Magnetic…

Machine Learning · Computer Science 2023-09-12 Alexander Norcliffe , Lev Proleev , Diana Mincu , Fletcher Lee Hartsell , Katherine Heller , Subhrajit Roy

State Space Models (SSMs) have emerged as a promising alternative to Transformers for long-context sequence modeling, offering linear $O(N)$ computational complexity compared to the Transformer's quadratic $O(N^2)$ scaling. This paper…

Machine Learning · Computer Science 2026-01-06 Abidemi Koledoye , Chinemerem Unachukwu , Gold Nwobu , Hasin Rana

The integration of RGB and thermal data can significantly improve semantic segmentation performance in wild environments for field robots. Nevertheless, multi-source data processing (e.g. Transformer-based approaches) imposes significant…

Computer Vision and Pattern Recognition · Computer Science 2025-06-24 Xiaodong Guo , Zi'ang Lin , Luwen Hu , Zhihong Deng , Tong Liu , Wujie Zhou

Mobile and wearable healthcare monitoring play a vital role in facilitating timely interventions, managing chronic health conditions, and ultimately improving individuals' quality of life. Previous studies on large language models (LLMs)…

Artificial Intelligence · Computer Science 2025-10-01 Xin Wang , Ting Dang , Xinyu Zhang , Vassilis Kostakos , Michael J. Witbrock , Hong Jia

The typical Selective State-Space Model (SSM) used in Mamba addresses several limitations of Transformers, such as the quadratic computational complexity with respect to sequence length and the significant memory requirements during…

Computation and Language · Computer Science 2025-10-24 Shengkun Tang , Liqun Ma , Haonan Li , Mingjie Sun , Zhiqiang Shen

Spatial Transcriptomics (ST) technologies provide biologists with rich insights into single-cell biology by preserving spatial context of cells. Building foundational models for ST can significantly enhance the analysis of vast and complex…

Genomics · Quantitative Biology 2025-07-24 Suyuan Zhao , Yizhen Luo , Ganbo Yang , Yan Zhong , Hao Zhou , Zaiqing Nie

Optimizing the structure of molecules to achieve desired properties is a central bottleneck across the chemical sciences, particularly in the pharmaceutical industry where it underlies the discovery of new drugs. Since molecular property…

Artificial Intelligence · Computer Science 2026-02-19 Fabian P. Krüger , Andrea Hunklinger , Adrian Wolny , Tim J. Adler , Igor Tetko , Santiago David Villalba

Recent State Space Models (SSMs) such as S4, S5, and Mamba have shown remarkable computational benefits in long-range temporal dependency modeling. However, in many sequence modeling problems, the underlying process is inherently modular…

Artificial Intelligence · Computer Science 2024-12-03 Jindong Jiang , Fei Deng , Gautam Singh , Minseung Lee , Sungjin Ahn

Structured State Space Models (SSMs) have emerged as a transformative paradigm in sequence modeling, addressing critical limitations of Recurrent Neural Networks (RNNs) and Transformers, namely, vanishing gradients, sequential computation…

This paper explores the spatial reasoning capability of large language models (LLMs) over textual input through a suite of five tasks aimed at probing their spatial understanding and computational abilities. The models were tested on both…

Computation and Language · Computer Science 2025-10-24 Maggie Bai , Ava Kim Cohen , Eleanor Koss , Charlie Lichtenbaum

Visual grounding is essential for precise perception and reasoning in multimodal large language models (MLLMs), especially in medical imaging domains. While existing medical visual grounding benchmarks primarily focus on single-image…

Computer Vision and Pattern Recognition · Computer Science 2025-05-20 Jingkun Yue , Siqi Zhang , Zinan Jia , Huihuan Xu , Zongbo Han , Xiaohong Liu , Guangyu Wang

The scaling law, which indicates that model performance improves with increasing dataset and model capacity, has fueled a growing trend in expanding recommendation models in both industry and academia. However, the advent of large-scale…

Information Retrieval · Computer Science 2026-01-30 Qihang Yu , Kairui Fu , Zhaocheng Du , Yuxuan Si , Kaiyuan Li , Weihao Zhao , Zhicheng Zhang , Jieming Zhu , Quanyu Dai , Zhenhua Dong , Shengyu Zhang , Kun Kuang , Fei Wu

Continuous sign language recognition (CSLR) requires precise spatio-temporal modeling to accurately recognize sequences of gestures in videos. Existing frameworks often rely on CNN-based spatial backbones combined with temporal convolution…

Computer Vision and Pattern Recognition · Computer Science 2025-12-30 Ahmed Abul Hasanaath , Hamzah Luqman

Markov state models (MSMs) have been demonstrated to be a powerful method for computationally studying intramolecular processes such as protein folding and macromolecular conformational changes. In this article, we present a new approach to…

Biological Physics · Physics 2015-06-18 Matthew R. Perkett , Michael F. Hagan

Despite the fundamental progress in autonomous molecular and materials discovery, data scarcity throughout chemical compound space still severely hampers the use of modern ready-made machine learning models as they rely heavily on the…

Chemical Physics · Physics 2023-11-30 Dominik Lemm , Guido Falk von Rudorff , O. Anatole von Lilienfeld
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