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Long Short-Term Memory (LSTM) is one of the most powerful sequence models. Despite the strong performance, however, it lacks the nice interpretability as in state space models. In this paper, we present a way to combine the best of both…

Machine Learning · Computer Science 2017-12-04 Xun Zheng , Manzil Zaheer , Amr Ahmed , Yuan Wang , Eric P Xing , Alexander J Smola

Image mass cytometry (IMC) enables high-dimensional spatial profiling by combining mass cytometry's analytical power with spatial distributions of cell phenotypes. Recent studies leverage large language models (LLMs) to extract cell states…

Computation and Language · Computer Science 2025-06-03 Chi-Jane Chen , Yuhang Chen , Sukwon Yun , Natalie Stanley , Tianlong Chen

In fluorescence microscopy, Single Molecule Localization Microscopy (SMLM) techniques aim at localizing with high precision high density fluorescent molecules by stochastically activating and imaging small subsets of blinking emitters.…

State-space models (SSMs) are an important modeling framework for analyzing ecological time series. These hierarchical models are commonly used to model population dynamics, animal movement, and capture-recapture data, and are now…

We present the Linear Complexity Sequence Model (LCSM), a comprehensive solution that unites various sequence modeling techniques with linear complexity, including linear attention, state space model, long convolution, and linear RNN,…

Computation and Language · Computer Science 2024-05-28 Zhen Qin , Xuyang Shen , Dong Li , Weigao Sun , Stan Birchfield , Richard Hartley , Yiran Zhong

Sequential sentence classification (SSC) in scientific publications is crucial for supporting downstream tasks such as fine-grained information retrieval and extractive summarization. However, current SSC methods are constrained by model…

Computation and Language · Computer Science 2024-12-02 Mengfei Lan , Lecheng Zheng , Shufan Ming , Halil Kilicoglu

Sequence modeling is a crucial area across various domains, including Natural Language Processing (NLP), speech recognition, time series forecasting, music generation, and bioinformatics. Recurrent Neural Networks (RNNs) and Long Short Term…

Machine Learning · Computer Science 2024-04-26 Badri Narayana Patro , Vijay Srinivas Agneeswaran

Although transformers dominate many code-specific tasks, they have significant limitations. This paper explores State Space Models (SSMs) as a promising alternative for code understanding tasks such as retrieval, classification, and clone…

Software Engineering · Computer Science 2025-09-23 Shweta Verma , Abhinav Anand , Mira Mezini

Multimodal Large Language Models (MLLMs) have achieved remarkable progress but incur substantial computational overhead and energy consumption during inference, limiting deployment in resource-constrained environments. Spiking Neural…

Neural and Evolutionary Computing · Computer Science 2026-04-22 Han Xu , Zhiyong Qin , Di Shang , Jiahong Zhang , Xuerui Qiu , Bo Lei , Tiejun Huang , Bo Xu , Guoqi Li

Scientific equation discovery is a fundamental task in the history of scientific progress, enabling the derivation of laws governing natural phenomena. Recently, Large Language Models (LLMs) have gained interest for this task due to their…

Computation and Language · Computer Science 2025-06-10 Parshin Shojaee , Ngoc-Hieu Nguyen , Kazem Meidani , Amir Barati Farimani , Khoa D Doan , Chandan K Reddy

Sequence models based on linear state spaces (SSMs) have recently emerged as a promising choice of architecture for modeling long range dependencies across various modalities. However, they invariably rely on discretization of a continuous…

Machine Learning · Computer Science 2023-11-15 Ankit Gupta , Harsh Mehta , Jonathan Berant

Multimodal large language models (MLLMs) have made remarkable progress in either temporal or spatial localization. However, they struggle to perform spatio-temporal video grounding. This limitation stems from two major challenges. Firstly,…

Computer Vision and Pattern Recognition · Computer Science 2025-04-14 Jiankang Wang , Zhihan Zhang , Zhihang Liu , Yang Li , Jiannan Ge , Hongtao Xie , Yongdong Zhang

As LLMs achieved breakthroughs in general reasoning, their proficiency in specialized scientific domains reveals pronounced gaps in existing benchmarks due to data contamination, insufficient complexity, and prohibitive human labor costs.…

Artificial Intelligence · Computer Science 2026-02-27 Peiyao Xiao , Xiaogang Li , Chengliang Xu , Jiayi Wang , Ben Wang , Zichao Chen , Zeyu Wang , Kejun Yu , Yueqian Chen , Xulin Liu , Wende Xiao , Bing Zhao , Hu Wei

Effectively modeling long spatiotemporal sequences is challenging due to the need to model complex spatial correlations and long-range temporal dependencies simultaneously. ConvLSTMs attempt to address this by updating tensor-valued states…

Machine Learning · Computer Science 2023-10-31 Jimmy T. H. Smith , Shalini De Mello , Jan Kautz , Scott W. Linderman , Wonmin Byeon

Large Audio Language Models (LALM) combine the audio perception models and the Large Language Models (LLM) and show a remarkable ability to reason about the input audio, infer the meaning, and understand the intent. However, these systems…

Audio and Speech Processing · Electrical Eng. & Systems 2024-11-26 Saurabhchand Bhati , Yuan Gong , Leonid Karlinsky , Hilde Kuehne , Rogerio Feris , James Glass

Continuous-time state-space models (SSMs) are flexible tools for analysing irregularly sampled sequential observations that are driven by an underlying state process. Corresponding applications typically involve restrictive assumptions…

Methodology · Statistics 2020-10-29 Sina Mews , Roland Langrock , Marius Ötting , Houda Yaqine , Jost Reinecke

Single-cell foundation models such as scGPT represent a significant advancement in single-cell omics, with an ability to achieve state-of-the-art performance on various downstream biological tasks. However, these models are inherently…

Machine Learning · Computer Science 2025-07-15 Steven Palayew , Bo Wang , Gary Bader

We present SCM (Sleep-Consolidated Memory), a research preview of a memory architecture for large language models that draws on neuroscientific principles to address a fundamental limitation in current systems: the absence of persistent,…

Machine Learning · Computer Science 2026-04-24 Saish Sachin Shinde

We present a simple and robust technique to extract kinetic rate models and thermodynamic quantities from single molecule time traces. SMACKS (Single Molecule Analysis of Complex Kinetic Sequences) is a maximum likelihood approach that…

Quantitative Methods · Quantitative Biology 2022-03-10 Sonja Schmid , Markus Götz , Thorsten Hugel

State space models (SSMs) achieve linear-time complexity but struggle with multi-channel physiological signals due to three limitations: fixed kernels cannot capture multi-scale temporal dynamics (motor preparation over hundreds of…

Signal Processing · Electrical Eng. & Systems 2026-05-05 Badri N. Patro , Vijay S. Agneeswaran