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We introduce Concept Bottleneck Large Language Models (CB-LLMs), a novel framework for building inherently interpretable Large Language Models (LLMs). In contrast to traditional black-box LLMs that rely on limited post-hoc interpretations,…

Computation and Language · Computer Science 2025-09-09 Chung-En Sun , Tuomas Oikarinen , Berk Ustun , Tsui-Wei Weng

Developing high-performing, yet interpretable models remains a critical challenge in modern AI. Concept-based models (CBMs) attempt to address this by extracting human-understandable concepts from a global encoding (e.g., image encoding)…

Machine Learning · Computer Science 2025-10-08 David Steinmann , Wolfgang Stammer , Antonia Wüst , Kristian Kersting

Deep neural networks for medical image classification often fail to generalize consistently in clinical practice due to violations of the i.i.d. assumption and opaque decision-making. This paper examines interpretability in deep neural…

Computer Vision and Pattern Recognition · Computer Science 2025-04-09 Mohammad Hossein Najafi , Mohammad Morsali , Mohammadreza Pashanejad , Saman Soleimani Roudi , Mohammad Norouzi , Saeed Bagheri Shouraki

Concept bottleneck models (CBMs) ensure interpretability by decomposing predictions into human interpretable concepts. Yet the annotations used for training CBMs that enable this transparency are often noisy, and the impact of such…

Machine Learning · Computer Science 2026-02-02 Seonghwan Park , Jueun Mun , Donghyun Oh , Namhoon Lee

Concept Bottleneck Models (CBMs) improve the explainability of black-box Deep Learning (DL) by introducing intermediate semantic concepts. However, standard CBMs often overlook domain-specific relationships and causal mechanisms, and their…

Machine Learning · Computer Science 2026-01-16 Reza M. Asiyabi , SEOSAW Partnership , Steven Hancock , Casey Ryan

Purpose: To develop CADIA, a supervised deep learning model based on a region proposal network coupled with a false-positive reduction module for the detection and localization of intracranial aneurysms (IA) from computed tomography…

Image and Video Processing · Electrical Eng. & Systems 2021-12-16 Dufan Wu , Daniel Montes , Ziheng Duan , Yangsibo Huang , Javier M. Romero , Ramon Gilberto Gonzalez , Quanzheng Li

Concept Bottleneck Models (CBMs) aim to deliver interpretable predictions by routing decisions through a human-understandable concept layer, yet they often suffer reduced accuracy and concept leakage that undermines faithfulness. We…

Machine Learning · Computer Science 2026-02-17 Karim Galliamov , Syed M Ahsan Kazmi , Adil Khan , Adín Ramírez Rivera

Interpretability is crucial to enhance trust in machine learning models for medical diagnostics. However, most state-of-the-art image classifiers based on neural networks are not interpretable. As a result, clinicians often resort to known…

Alzheimer's disease (AD) diagnosis is complex, requiring the integration of imaging and clinical data for accurate assessment. While deep learning has shown promise in brain MRI analysis, it often functions as a black box, limiting…

Image and Video Processing · Electrical Eng. & Systems 2025-03-04 Yexiao He , Ziyao Wang , Yuning Zhang , Tingting Dan , Tianlong Chen , Guorong Wu , Ang Li

Intracranial aneurysms (IAs) are generally asymptomatic and thus often discovered incidentally on angiographic scans like 3D DSA, CTA and MRA. Skilled radiologists achieved a sensitivity of 88% by means of visual detection, which seems…

Image and Video Processing · Electrical Eng. & Systems 2020-06-01 Žiga Bizjak , Boštjan Likar , Franjo Pernuš , Žiga Špiclin

A commonly adopted approach to carry out detection tasks in medical imaging is to rely on an initial segmentation. However, this approach strongly depends on voxel-wise annotations which are repetitive and time-consuming to draw for medical…

The development of diagnostic models is gaining traction in the field of psychiatric disorders. Recently, machine learning classifiers based on resting-state functional magnetic resonance imaging (rs-fMRI) have been developed to identify…

Machine Learning · Computer Science 2025-10-06 Tianzheng Hu , Qiang Li , Shu Liu , Vince D. Calhoun , Guido van Wingen , Shujian Yu

Concept Bottleneck Models (CBMs) have garnered much attention for their ability to elucidate the prediction process through a human-understandable concept layer. However, most previous studies focused on static scenarios where the data and…

Machine Learning · Computer Science 2026-01-05 Hongbin Lin , Chenyang Ren , Juangui Xu , Zhengyu Hu , Cheng-Long Wang , Yao Shu , Hui Xiong , Jingfeng Zhang , Di Wang , Lijie Hu

Concept Bottleneck Models (CBMs) and other concept-based interpretable models show great promise for making AI applications more transparent, which is essential in fields like medicine. Despite their success, we demonstrate that CBMs…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Jessica Bader , Leander Girrbach , Stephan Alaniz , Zeynep Akata

Accurate and interpretable classification of brain tumors from magnetic resonance imaging (MRI) is critical for effective diagnosis and treatment planning. This study presents an ensemble-based deep learning framework that combines…

Image and Video Processing · Electrical Eng. & Systems 2025-08-12 Melika Filvantorkaman , Mohsen Piri , Maral Filvan Torkaman , Ashkan Zabihi , Hamidreza Moradi

Concept Bottleneck Models (CBMs) offer inherent interpretability by initially translating images into human-comprehensible concepts, followed by a linear combination of these concepts for classification. However, the annotation of concepts…

Computer Vision and Pattern Recognition · Computer Science 2025-06-24 Hangzhou He , Lei Zhu , Xinliang Zhang , Shuang Zeng , Qian Chen , Yanye Lu

Recent advancements in AI and medical imaging offer transformative potential in emergency head CT interpretation for reducing assessment times and improving accuracy in the face of an increasing request of such scans and a global shortage…

Intracranial aneurysms are a commonly occurring and life-threatening condition, affecting approximately 3.2% of the general population. Consequently, detecting these aneurysms plays a crucial role in their management. Lesion detection…

Computer Vision and Pattern Recognition · Computer Science 2023-05-24 Maysam Orouskhani , Negar Firoozeh , Shaojun Xia , Mahmud Mossa-Basha , Chengcheng Zhu

Concept Bottleneck Models (CBMs) provide inherent interpretability by first mapping input samples to high-level semantic concepts, followed by a combination of these concepts for the final classification. However, the annotation of…

Machine Learning · Computer Science 2026-03-02 Yangyi Li , Mengdi Huai

Concept Bottleneck Models (CBMs) enhance the interpretability of AI systems, particularly by bridging visual input with human-understandable concepts, effectively acting as a form of multimodal interpretability model. However, existing CBMs…

Machine Learning · Computer Science 2025-08-06 Songning Lai , Mingqian Liao , Zhangyi Hu , Jiayu Yang , Wenshuo Chen , Hongru Xiao , Jianheng Tang , Haicheng Liao , Yutao Yue
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